Executive control in schizophrenia: a preliminary study on the moderating role of <i>COMT</i> Val158Met for comorbid alcohol and substance use disorders

Carrà, Giuseppe; Nicolini, Gabriella; Crocamo, Cristina; Lax, Annamaria; Amidani, F.; Bartoli, Francesco; Castellano, F.; Chiorazzi, A; Gamba, Giulia; Papagno, Costanza; Clerici, Massimo

doi:10.1080/08039488.2017.1286385

Cited by 5 publications

(2 citation statements)

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“…Last but not the least, the RBANS has five domains including immediate memory, attention, language, visuospatial/ constructional, and delayed memory. However, in fact, there are more cognitive domains such as executive function, working memory [43], emotional management, and facial emotion perception [44–45]. In the future study, more cognitive domains should be examined and the different ethnic population should be recruited to confirm our findings.…”

Section: Discussionmentioning

confidence: 72%

FOXP2 contributes to the cognitive impairment in chronic patients with schizophrenia

Lang

Zhang

Song

et al. 2019

Aging

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The forkhead-box P2 (FOXP2), involving in language and memory function, has been identified as susceptibility to schizophrenia. However, no study examined the role of FOXP2 on cognitive impairment in schizophrenia. Total 1106 inpatients with schizophrenia and 404 controls were recruited and genotyped. Among them, 867 patients and 402 controls were assessed through the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). SHEsis software was used to investigate the association of FOXP2 rs10447760 with schizophrenia, followed by logistic regression. The model of covariance (ANCOVA) and multivariate analysis were conducted to investigate the effect of FOXP2 rs10447760 on cognitive impairment in schizophrenia. No differences in the genotypic and allelic frequencies of the FOXP2 rs10447760 were found between patients and controls (both p> 0.05). Except for the visuospatial/constructional score (p > 0.05), other five RBANS scores were lower in patients compared to controls (all p < 0.0001). Interestingly, we found immediate memory score was lower in patients carrying genotype CT compared to genotype CC (F=5.19, p=0.02), adjusting for confounding data. Our study suggested that FOXP2 rs10447760 has no effect on the susceptibility to schizophrenia, while it may be associated with its cognitive impairment, especially immediate memory in chronic schizophrenia.

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Section: Discussionmentioning

confidence: 72%

FOXP2 contributes to the cognitive impairment in chronic patients with schizophrenia

Lang

Zhang

Song

et al. 2019

Aging

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“…People with schizophrenia show severe executive dysfunctions associated with both negative and disorganized symptoms (Braw, Benozio, & Levkovitz, ), in particular, those who abuse psychoactive substances (Carrà et al, ; Tosato et al, ). Over the past 25 years, a considerable body of literature has established the presence of facial emotion recognition (FER) impairment in schizophrenia, which affects quality of life and psychosocial functioning (Kohler, Walker, Martin, Healey, & Moberg, ; Savla, Vella, Armstrong, Penn, & Twamley, ).…”

Section: Introductionmentioning

confidence: 99%

Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met

Carrà

Nicolini

Lax

et al. 2017

Human Psychopharmacology

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This study is the first to date examining the impact of AUDs/SUDs and COMT variants on FER in an epidemiologically representative sample of subjects with schizophrenia. Our findings do not suggest an additional impairment from comorbid AUDs/SUDs on FER among subjects with schizophrenia, whilst COMT Val158Met, though based on a limited sample, might have a role just among those without AUDs/SUDs. Based on our results, additional research is needed also exploring differential roles of various substances.

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Pharmacological cognitive enhancers

Peltier

Sofuoglu

2020

Cognition and Addiction

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Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders

Cited by 5 publications

References 50 publications

FOXP2 contributes to the cognitive impairment in chronic patients with schizophrenia

FOXP2 contributes to the cognitive impairment in chronic patients with schizophrenia

Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met

Pharmacological cognitive enhancers

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