Excretion of pathogenic Newcastle disease virus by double‐crested cormorants (<i>Phalacrocorax auritus</i>) in absence of mortality or clinical signs of disease

Kuiken, Thijs; Heckert, Robert A.; Riva, José; Leighton, F. A.; Wobeser, Gary A.

doi:10.1080/03079459808419381

Cited by 27 publications

(22 citation statements)

References 8 publications

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“…The involvement of the respiratory system was minimal. As described for the cormorants infected with NDV, 5,10,[22][23][24] clinicopathological findings in the chickens involved mainly the nervous system, suggesting that the tropism and the behavior of the virus were similar in different hosts. The development of clinical disease in chickens inoculated with a strain rescued from wild birds (cormorant) underlines the important role that wild birds could have in the natural or accidental transmission of virulent strain to commercial flocks.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Characterization in Poultry of Three Strains of Newcastle Disease Virus Isolated From Recent Outbreaks

et al. 2010

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Newcastle disease is a severe threat to the poultry industry and is caused by Newcastle disease virus, a member of the genus Avulavirus, family Paramyxoviridae. The virus is rapidly evolving, and several new genotypes have been discovered in the past few years. Characterization of these strains is important to evaluate field changes, anticipate new outbreaks, and develop adequate control measures. Three Newcastle disease isolates (APMV-1/duck/Vietnam, Long Bien/78/2002, APMV-1/chicken/ Australia/9809-19-1107/1998, and APMV-1/double-crested cormorant/USA, Nevada/19529-04/2005) from recent outbreaks were investigated via clinicopathological assessment, immunohistochemistry (IHC), in situ hybridization, virus isolation, and serology in experimentally infected 4-week-old chickens. Phylogenetic studies showed that Australia isolate belongs to class II genotype I, Long Bien to class II genotype VIId, and Nevada cormorant to class II genotype V. Even though all 3 viruses had a virulent fusion protein cleavage site and ICPI values greater than 1.5, they all differed in their ability to cause clinical signs, in their lesions, and in their viral distribution in body tissues. The Long Bien isolate showed the most severe clinicopathological picture and the most widespread viral distribution. The Australia and Nevada cormorant isolates had a milder pathological phenotype, with viral replication restricted to only a few organs. The variability in clinicopathological characteristics despite the similarity in ICPI suggests that full clinicopathological assessment is necessary to fully characterize new isolates and that there are differences in pathogenesis among viruses of different genotypes.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Characterization in Poultry of Three Strains of Newcastle Disease Virus Isolated From Recent Outbreaks

et al. 2010

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“…Antigenic and genetic analyses of the viruses suggested that all of the 1990 and 1992 viruses were very closely related despite the geographical separation of the hosts. Disease in double-crested cormorants was observed again in Canada in 1995 and in California in 1997, and in both instances NDV was isolated from dead birds; as before, these viruses appear to be closely related (Kuiken et al, 1998). Since these outbreaks covered cormorants that would follow different migratory routes it seemed most probable that initial infection occurred at a mutual wintering area in south USA or Central America.…”

Section: Virulent Ndv Infections Of Wild Birdsmentioning

confidence: 97%

Newcastle disease in the European Union 2000 to 2009

Alexander

2011

Avian Pathology

131

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“…It has a wide host range, infecting 27 of the 50 orders of birds (Jørgensen et al, 1998;Kuiken et al, 1998;Schelling et al, 1999;Alexander, 2000). The virus is transmitted by ingestion or inhalation and produces a disease of variable clinical severity and transmissibilit y depending on its pathotype.…”

Section: Introductionmentioning

confidence: 99%

Newcastle disease virus: Macromolecules and opportunities

Yusoff¹,

Tan²

2001

Avian Pathology

140

111

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Over the past two decades, enormous advances have occurred in the structural and biological characterization of Newcastle disease virus (NDV). As a result, not only the complete sequence of the viral genome has been fully determined, but also a clearer understanding of the viral proteins and their respective roles in the life cycle has been achieved. This article reviews the progress in the molecular biology of NDV with emphasis on the new technologies. It also identifies the fundamental problems that need to be addressed and attempts to predict some research opportunities in NDV that can be realized in the near future for the diagnosis, prevention and treatment of disease(s).

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Excretion of pathogenic Newcastle disease virus by double‐crested cormorants (Phalacrocorax auritus) in absence of mortality or clinical signs of disease

Cited by 27 publications

References 8 publications

Clinicopathological Characterization in Poultry of Three Strains of Newcastle Disease Virus Isolated From Recent Outbreaks

Clinicopathological Characterization in Poultry of Three Strains of Newcastle Disease Virus Isolated From Recent Outbreaks

Newcastle disease in the European Union 2000 to 2009

Newcastle disease virus: Macromolecules and opportunities

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