Excretion of Bile Pigment and Hepatic Function in Diseases of the Blood

A Study of Some Metabolic Processes Dependent on Coenzyme ‘A’ in Pernicious Anaemia

“…The low cholesterol ester fraction in the serum of patients with pernicious anaemia reported in the paper of F roehlich et al (4) and in our own results, might, therefore, be related to a reduced hepatic coenzyme "A" activity in this disease. The synthesis of hippuric acid from benzoic acid is also dependent on coenzyme "A" and this is principally a hepatic process (16 to hippuric acid synthesis in our patients confirm the findings of previous workers with this test in pernicious anaemia (17,18,19). In normal health, the potential rate of hippuric acid excretion by the kidney is higher than the rate of hepatic synthesis, but in renal disease a reduction in hippuric acid excretion may occur (20,21).…”