Familial Nonhemolytic Jaundice

Pathogenesis and Classification of Jaundice

“…The condition was first reported by Gilbert and Lereboullet in 1901, and the subsequent literature was well reviewed by Dubin and Johnson in 1954. Studies following the intravenous injection of bilirubin suggest that the abnormality lies in the inability of the liver cells to transport bilirubin, the excretion rate certainly being much slower than normal (Dameshek and Singer, 1941). Dubin and Johnson (1954) described another rare constitutional form of chronic benign jaundice characterized by the presence of an unusual pigment in the liver.…”

Clinical Significance of Jaundice

“…In 1901 Gilbert and Lereboullet described cases of jaundice in which there was no haemolysis and no anatomical lesion of the liver or bile ducts. The condition was later described by Dameshek and Singer (1941) as “familial non‐haemolytic jaundice” and by Rozendaal and others as “constitutional hepatic dysfunction”. Meulengracht (1947) described the same disease under the title “Chronic Intermittent Juvenile Jaundice”.…”

Constitutional Hepatic Dysfunction

“…Improved obstetrical and gynxcological practice may partly explain the paucity of more recent reports, which precludes the potentially useful contrast of early spontaneous uterine rupture with that occurring at or about full term unider conditions of modern medical practice. In these few reports, spontaneous uterine rupture in the first and second trimesters, as later in pregnancy, has been reported as a sequel to Coesarean section 5,14 and to other operations which may be supposed to lead to scars in the myometrium.9 ' …”