Exclusive Expression of Kinesin Gene in Chemosnsory Neurons Open to the External Environment

All kinesin superfamily protein, KIF, genes in mouse and human

“…cause defects in chemosensory responses (74). Osm3 is necessary for sensory cilia growth in the dendrites of sensory neurons.…”

Going mobile: microtubule motors and chromosome segregation.

“…Unlike the diverse number of kinesin-related genes, thus far there appears to be but one cytoplasmic dynein heavy chain gene in most organisms (37)(38)(39)(40)(41)(42). Recent evidence suggests that cytoplasmic dynein functional diversity is achieved through the association of the heavy chain with a variety of accessory proteins that target and regulate its activity (8,43,44 (89), and epitope-tagged CIN8 or KIP1 (48,49), shows that these bimC family members are distributed along the length of spindle microtubules during mitosis. Addi-*To avoid confusion caused by organismspecific genetic nomenclatures, we have adopted a simplified nomenclature system for this review.…”

“…The novel feature of KRP85/95 is the ability of its two kinesinlike subunits to heterodimerize, possibly through their coiled-coil stalk domains (121). This may be a general principle, since related KLPs have been identified in mouse (66,122,123), Drosophila (124), Chlamydomonas (125), and Caenorhabditis (44,124), suggesting that these KLPs are members of a new kinesin family (4, 84). Therefore, the potential for KLPs to form different types of oligomers is another mechanism that may be used to generate variation in motor output, and it stresses the importance of identifying and characterizing native motor protein complexes (126).…”

Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein Gαq and excitable cells inC.elegans

“…The dauer is an arrested, alternative third stage of larval development that occurs under conditions of high population density and reduced food supply (reviewed by Riddle and Albert, 1997). Both entry and exit from dauer are controlled by chemosensory cues involving neurons (Bargmann and Horvitz, 1991;Shakir et al, 1993;Tabish et al, 1995), suggesting that excitable cells have…”