Going mobile: microtubule motors and chromosome segregation.

Abstract

Proper chromosome segregation in eukaryotes depends upon the mitotic and meiotic spindles, which assemble at the time of cell division and then disassemble upon its completion. These spindles are composed in large part of microtubules, which either generate force by controlled polymerization and depolymerization or transduce force generated by molecular microtubule motors. In this review, we discuss recent insights into chromosome segregation mechanisms gained from the analyses of force generation during meiosis and mitosis. These analyses have demonstrated that members of the kinesin superfamily and

Novel Piperazine-based Compounds Inhibit Microtubule Dynamics and Sensitize Colon Cancer Cells to Tumor Necrosis Factor-induced Apoptosis

“…Microtubules have long been known as the drivers of chromosome migration and chromosome segregation (45). Microtubules become highly dynamic during mitosis and generate bipolar spindles that capture the sister chromatids and align them at the equatorial plate (46,47).…”

Specific K-ras2 Mutations in Human Sporadic Colorectal Adenomas Are Associated with DNA Near-Diploid Aneuploidy and Inhibition of Proliferation

“…42 Perhaps ras oncogene functions that regulate the formation of stress fibers, focal cell adhesion, and *DI indicates the degree of DNA aneuploidy (DI ϭ 1 for DNA diploidy) evaluated according to multiparametric flow cytometry. Flow cytometry sorting was used to separate epithelial nuclei to be submitted to K-ras2 analysis (see Materials and Methods).…”

Interaction of Arabidopsis kinesin‐like calmodulin‐binding protein with tubulin subunits: modulation by Ca2+‐calmodulin

“…Although kinesins and KLPs are related to one another in having a highly conserved motor domain, KLPs show considerable variation in the location of the motor domain and motility properties (Barton and Goldstein, 1996;Moore and Endow, 1996). KLPs with amino-terminal and centrally located motor domains move toward microtubule plus ends, whereas KLPs with carboxy-terminal motor domains move toward minus end of microtubules (Barton and Goldstein, 1996;Moore and Endow, 1996).…”