Exclusive enteral nutrition induces early clinical, mucosal and transmural remission in paediatric Crohn’s disease

Grover, Zubin; Muir, Richard; Lewindon, Peter

doi:10.1007/s00535-013-0815-0

Cited by 170 publications

(174 citation statements)

References 42 publications

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“…88 In some studies, early EEN is effective in inducing clinical, biochemical, and mucosal remission and improves outcomes at 1 year. [89][90][91] Although EEN has been successfully used and proven to be highly effective, it is often not preferred by patients due to the difficulty involved in administration. It may require tube feeding and typically consists of no food for 6 weeks.…”

Section: Dietary Recommendationsmentioning

confidence: 99%

Health Care Maintenance for the Pediatric Patient With Inflammatory Bowel Disease

DeFilippis

Barfield

2016

Pediatrics

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Nearly one-quarter of patients with inflammatory bowel disease (IBD) are younger than 20 years of age at diagnosis. Furthermore, the incidence of IBD in children continues to increase. Nevertheless, variation in management exists within the care of patients with IBD with regards to disease screening and preventive care. A multidisciplinary approach that involves the general practitioner and pediatric gastroenterologist is needed to routinely monitor growth, bone health, vitamin and mineral deficiencies, vaccination status, and endoscopic surveillance. It is also important to monitor for extraintestinal manifestations of IBD that may affect the liver, joints, skin, and eyes. The purpose of this article is to provide an updated overview of comprehensive care for pediatric patients with IBD.

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Section: Dietary Recommendationsmentioning

confidence: 99%

Health Care Maintenance for the Pediatric Patient With Inflammatory Bowel Disease

DeFilippis

Barfield

2016

Pediatrics

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“…17 On a broader level, determining overall nutritional strategy also has an effect on gastrointestinal tract wound healing in Crohn's disease. Exclusive enteral nutrition has been shown to be beneficial in pediatric patients with Crohn's disease, 18 and in some cases yields dramatic improvements in the levels of proinflammatory mediators such as IL-1, IL-2, IL-8, and interferon-c. Elemental and polymeric diets have also been shown to have anti-inflammatory effects in vitro, although not in a live model. Enteral nutrition also improved the levels of insulin-like growth factor (IGF)-1 and IGF-binding protein, which were correlated to improved clinical outcome.…”

Section: Discussion Of Findings and Relevant Literature Nutritional Amentioning

confidence: 99%

Nutritional Aspects of Gastrointestinal Wound Healing

Mukherjee

Kavalukas

Barbul

2016

Advances in Wound Care

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Significance: Although the wound healing cascade is similar in many tissues, in the gastrointestinal tract mucosal healing is critical for processes such as inflammatory bowel disease and ulcers and healing of the mucosa, submucosa, and serosal layers is needed for surgical anastomoses and for enterocutaneous fistula. Failure of wound healing can result in complications including infection, prolonged hospitalization, critical illness, organ failure, readmission, new or worsening enterocutaneous fistula, and even death. Recent Advances: Recent advances are relevant for the role of specific micronutrients, such as vitamin D, trace elements, and the interplay between molecules with pro-and antioxidant properties. Our understanding of the role of other small molecules, genes, proteins, and macronutrients is also rapidly changing. Recent work has elucidated relationships between oxidative stress, nutritional supplementation, and glucose metabolism. Thresholds have also been established to define adequate preoperative nutritional status. Critical Issues: Further work is needed to establish standards and definitions for measuring the extent of wound healing, particularly for inflammatory bowel disease and ulcers. In addition, a mounting body of evidence has determined the need for adequate preoperative nutritional supplementation for elective surgical procedures. Future Directions: A large portion of current work is restricted to model systems in rodents. Therefore, additional clinical and translational research is needed in this area to promote gastrointestinal wound healing in humans, particularly those suffering from critical illness, patients with enterocutaneous fistula, inflammatory bowel disease, and ulcers, and those undergoing surgical procedures.

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“…Previous studies have demonstrated short-term EEN efficacy with better side effect profile [6] improved growth velocity, weight gain, lean body mass, and bone health [6][7][8][9][10][11][12][13]. On the basis of such evidence demonstrating efficacy and other beneficial effects, EEN is considered a first-line induction therapy in pediatric CD [14].…”

Section: Introductionmentioning

confidence: 93%

Time to Relapse in Children with Crohn’s Disease Treated with Azathioprine and Nutritional Therapy or Corticosteroids

et al. 2016

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Exclusive enteral nutrition induces early clinical, mucosal and transmural remission in paediatric Crohn’s disease

Abstract: EEN is effective for inducing early clinical, biochemical, mucosal and transmural remission. Early endoscopic remission improves outcomes at 1 year.

Cited by 170 publications

References 42 publications

Health Care Maintenance for the Pediatric Patient With Inflammatory Bowel Disease

Health Care Maintenance for the Pediatric Patient With Inflammatory Bowel Disease

Nutritional Aspects of Gastrointestinal Wound Healing

Time to Relapse in Children with Crohn’s Disease Treated with Azathioprine and Nutritional Therapy or Corticosteroids

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