Exclusion of immune proteasomes from mouse ascitic carcinoma Krebs-II cells

Astakhova, T. Yu.; Шарова, Н. П.

doi:10.1134/s1062359006030022

Cited by 9 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The experiments revealed reduced content of proteasome immune pools in ascitic carcinoma Krebs-II cells compared to normal tissues [2]. The content of proteasomes and their activity in human malignant tumors received little attention.…”

mentioning

confidence: 99%

Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas

et al. 2010

Self Cite

View full text Add to dashboard Cite

The development of malignant neoplasm of the head and neck is related to the state of intracellular proteasome system. Elevation of total activity of proteasomes and specific activity of 20S proteasomal pool are accompanied by changes in proteasomal composition. Tumor size correlated with the content of regulatory proteasomal complex PA28. In the presence of regional metastases, 26S proteasome activity decreases and the content of proteasome immune subunit LMP7 in the tumor increases.

show abstract

mentioning

confidence: 99%

Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…We discovered that in growing tumors, the ascite carcinoma Krebs-II in Balb/c mice and the carcinosarcoma Walker 256 in Wag rats, the amount of the immune subunits of the proteasomes significantly decreased [42,75]. Besides, we investigated the Walker 256 tumor growth and the expression pattern of the proteasomes in it in unique Brattleboro rats defective in vasopressin synthesis.…”

Section: Immune Proteasomes In Tumor Cellsmentioning

confidence: 98%

“…Only those are indicated in Fig. (2), in which the immune and constitutive proteasomes were studied [40,42,43]. In addition, a correlation between the amount of the immune proteasomes and immune system cells in different organs can be observed.…”

Section: Immune Proteasomesmentioning

confidence: 98%

“…According to the ratio between the immune and constitutive proteasomes, different organs and tissues can be arranged in a common logical sequence. The extreme positions in this sequence are occupied by the brain, which contains predominantly the constitutive proteasomes [40], and lymphoid organs enriched with the immune proteasomes [40][41][42]. All other organs and tissues can be placed in the interval between the extreme points.…”

Section: Immune Proteasomesmentioning

confidence: 99%

See 1 more Smart Citation

Multiple Forms of Proteasomes and their Role in Tumor Fate

Zakharova¹

2008

EMI

View full text Add to dashboard Cite

Mammalian and human cells contain multiple forms of proteasomes different in their structure and functions. 26S-proteasome pool regulates most cellular processes through ATP-and ubiquitin-dependent hydrolysis of proteins participating in these processes. This function is possible due to 19S-subparticle capable to recognize ubiquitinated proteins, unfold and direct them into the proteolytic chamber. 20S-proteasome pool is capable to degrade some damaged and foreign proteins in an ATP-and ubiquitin-independent manner. Among both proteasome pools, the immune proteasomes effectively produce antigen epitopes for MHC class I molecules and play a crucial role in the antitumor immunity. Excluding the immune proteasomes from their cells, numerous tumors avoid the immune system. On the contrary, tumor cells enhance the expression of the housekeeping proteasomes and 19S-subparticle.At this time, bortezomib, a patented proteasome inhibitor, is used as an anticancer therapy. This drug induces the cell cycle arrest and apoptosis of dividing tumor cells. However, bortezomib causes, firstly, deviations in immune functions, secondly, the increase of the housekeeping proteasome expression by a feedback mechanism. Taking into account the recent patents, we consider prospects of the development of new drugs directed to the regulation of the expression of the immune and housekeeping proteasomes and 19S-subparticle in tumor cells.

show abstract

“…It was experimentally shown that the activity and composition of the 26S protea some varied in the in vivo process of oncogenesis [7]. The role of ubiquitin dependent proteolysis in the pathogenesis of malignant tumors in different local izations, particularly, the prostate gland [8], mammary gland [9], intestine [10], and other organs, is being intensely studied.…”

Section: Introductionmentioning

confidence: 99%

Proteasome activity in tumors of the female reproductive system

et al. 2012

View full text Add to dashboard Cite

Proteasomes (multiproteinase protein complexes) are known to play an important role in cancer pathogenesis, however, few information about their activity in human tumor tissues is available so far. We studied chymotrypsin-like activity of proteasomes in tissues of breast cancer (BC) and endometrial cancer (EC). The chymotrypsin-like total proteasome activity and the 20S and 26S proteasome activity in malignant tissues were shown to be significantly higher in malignant tumors than in normal tissues. No increase in proteasome activity was registered with larger tumor size in both BC and EC, whereas proteasome activity was changed with respect to the extent of tumor involvement. In breast cancer tissues, significant reductions in the total and the 26S proteaome activities were observed in tumors with regional lymph node metastases as compared to tumors without metastases. In endometrial cancer tissues, the total proteasome activity and the 20S and 26S proteasome activities were increased as the depth of myometrial invasion. The data obtained indicate that the proteasome acyivity is significantly changed in the process of cancerogenesis and further study is needed to develop new additional prognostic criteria and effective anti-tumor agents in molecular-directed therapy.

show abstract

Exclusion of immune proteasomes from mouse ascitic carcinoma Krebs-II cells

Cited by 9 publications

References 19 publications

Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas

Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas

Multiple Forms of Proteasomes and their Role in Tumor Fate

Proteasome activity in tumors of the female reproductive system

Contact Info

Product

Resources

About