Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas

Спирина, Л. В.; Kondakova, I. V.; Чойнзонов, Е. Л.; Шарова, Н. П.; Chigevskay, S. Y.; Shishkin, D. A.

doi:10.1007/s10517-010-0881-8

Cited by 7 publications

(3 citation statements)

References 11 publications

(14 reference statements)

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“…But a low expression of TRIM16 is a favorable prognostic sign in ovarian cancers [21]. It is also noted that the progression of prostate cancer is associated with overexpression of ERs, which is also revealed in our studies [42, 43]. This is consistent with the fact that the protein encoded by the TRIM16 gene has anti-estrogenic activity, reducing the expression of ERs in the cell.…”

Section: Introductionsupporting

confidence: 90%

Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception

Спирина

Yunusova

Кондакова

et al. 2019

Heliyon

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Sex hormones, regulating normal physiological processes of most tissues and organs, are considered to be one of the key factors in the development of hormone-dependent cancer and formation of the hormone-resistant tumor phenotype. Recently, the importance of the system for control of hormone receptors expression mediated by nuclear peptides became evident. This system is involved in the regulation of normal physiological processes, in the pathogenesis of many diseases as well as oncogenesis. In the review, we discuss the relationships of the two regulatory peptides – Brn-3α, TRIM16 with hormone receptors. The transcription factor Brn-3α is able to affect the transcription activity of androgen and estrogen receptors. It is observed the participation of TRIM16 protein in the pathogenesis of hormone-dependent tumors due to its "anti-estrogenic effect". Additionally, they are involved in the key intracellular processes, such as proliferation, cell differentiation, and programmed death - apoptosis. Thus, Brn-3α and TRIM16 are associated with cancer development and progression. By understanding these alterations, we can identify potential markers and novel biochemical therapeutic targets. It makes clear the association between classical hormone-dependent tumors and less sensitive ones with the modification in the level of hormone receptors.

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Section: Introductionsupporting

confidence: 90%

Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception

Спирина

Yunusova

Кондакова

et al. 2019

Heliyon

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“…С другой стороны, для рака яичника низкое значение показателя является благоприятным прогностическим признаком [6]. Отмечено также, что быстрое прогрессирование рака предстательной железы связано с гиперэкспрессией ER, что выявлено в наших исследованиях [22,23]. Это согласуется с тем, что кодируемый геном TRIM16 белок обладает антиэстрогенной активностью, снижая экспрессию ER в клетке.…”

Section: рис 1 значение Trim16 в развитии злокачественных новообразunclassified

Role of TRIM16 in cancers development

2019

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Тhe protein TRIM16 is involved in key intracellular processes, such as proliferation, cell differentiation and programmed death, including intrinsic and extrinsic apoptosis, autophagy-dependent cell death and immunogenic cell death. The TRIM16 protein acts the proteins TPD43, Gli-1, RARβ, Snail components and MAPK signaling pathway, cadherins, caspases and is also associated with the regulation of the immune system via direct and indirect mechanisms. The influence of TRIM16 protein on the pathogenesis of hormone-dependent tumors is well-known. Further study of the TRIM16 role in the development and progression of malignant neoplasms will form the basis for the development of new methods for predicting the course of the malignant process.

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“…Усиление протеолиза в опухолевых клетках обуслов-лено высоким уровнем метаболизма и интенсивностью таких процессов, как пролиферативная активность, инва-зивный рост, метастазирование [26]. В клетках неоплазмы происходит постоянное обновление белкового и пептид-ного состава.…”

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Внутриклеточные Протеолитические Системы: Новый Класс Маркеров Для Ранней Диагностики И Прогноза Течения Злокачественных Опухолей

Кондакова¹,

Шашова²,

Спирина³

et al. 2017

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Activity and Subunit Composition of Proteasomes in Head and Cervical Squamous Cell Carcinomas

Cited by 7 publications

References 11 publications

Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception

Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception

Role of TRIM16 in cancers development

Внутриклеточные Протеолитические Системы: Новый Класс Маркеров Для Ранней Диагностики И Прогноза Течения Злокачественных Опухолей

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