Excitatory Postrhinal Projections to Principal Cells in the Medial Entorhinal Cortex

Koganezawa, Noriko; Gisetstad, Ragnhild; Husby, Ellen; Doan, Thanh Pierre; Witter, Menno P.

doi:10.1523/jneurosci.0653-15.2015

Cited by 26 publications

(35 citation statements)

References 66 publications

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“…Information about speed in MEC could partially originate in visual cortex, where both locomotion and optic flow influence the speed tuning of neurons 35 . Visual inputs compose a significant fraction of cortical inputs to MEC 36 , reaching MEC through either direct projections from primary visual areas 36,37 , or indirectly via projections from the postrhinal cortex 36,38 . These visual inputs could include signals that are asymmetric with respect to VR gain.…”

Section: Discussionmentioning

confidence: 99%

Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation

et al. 2018

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To guide navigation, the nervous system integrates multisensory self-motion and landmark information. We examined how these inputs generate the representation of self-location by recording entorhinal grid, border and speed cells in mice navigating virtual environments. Manipulating the gain between the animal’s locomotion and the visual scene revealed that border cells responded to landmark cues while grid and speed cells responded to combinations of locomotion, optic flow, and landmark cues in a context-dependent manner, with optic flow becoming more influential when it was faster than expected. A network model explained these results, providing principled regimes under which grid cells remain coherent with or break away from the landmark reference frame. Moreover, during path integration-based navigation, mice estimated their position following the principles predicted by our recordings. Together, these results provide a quantitative framework for understanding how landmark and self-motion cues combine during navigation to generate spatial representations and guide behavior.

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Section: Discussionmentioning

confidence: 99%

Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation

et al. 2018

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“…Although cells of all functionally defined cell types responded to light, border cells appear especially sensitive to manipulation of visual inputs. An important cortical afferent carrying visual information to the MEC originates in the postrhinal cortex ( Burwell and Amaral, 1998a , 1998b ) and has a depolarizing effect on principal neurons of the MEC ( Koganezawa et al, 2015 ). It is tempting to speculate that this projection is more active when visual landmarks are present.…”

Section: Discussionmentioning

confidence: 99%

Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex

Pérez-Escobar

Kornienko

Latuske

et al. 2016

eLife

110

153

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Neurons of the medial entorhinal cortex (MEC) provide spatial representations critical for navigation. In this network, the periodic firing fields of grid cells act as a metric element for position. The location of the grid firing fields depends on interactions between self-motion information, geometrical properties of the environment and nonmetric contextual cues. Here, we test whether visual information, including nonmetric contextual cues, also regulates the firing rate of MEC neurons. Removal of visual landmarks caused a profound impairment in grid cell periodicity. Moreover, the speed code of MEC neurons changed in darkness and the activity of border cells became less confined to environmental boundaries. Half of the MEC neurons changed their firing rate in darkness. Manipulations of nonmetric visual cues that left the boundaries of a 1D environment in place caused rate changes in grid cells. These findings reveal context specificity in the rate code of MEC neurons.DOI: http://dx.doi.org/10.7554/eLife.16937.001

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“…POR is reciprocally connected with PPC (Burwell and Amaral, ; Agster and Burwell, ), and is also reciprocally connected with MEC (Burwell and Amaral, ) providing a major excitatory input to superficial layers of MEC (Koganezawa et al, ). Since the sparse PPC projections mainly target layer VI of POR while projections to MEC originate in superficial layers of this area (Burwell and Amaral, ; Koganezawa et al, ), it is likely that local POR circuits need to be bypassed but the detailed circuitry within POR remains to be established. It is worth mentioning that POR receives a larger proportion of input from V2 than from PPC (Burwell and Amaral, ), suggesting that visual areas may have a stronger influence on POR activity than PPC.…”

Section: Comparative Considerationsmentioning

confidence: 99%

Parahippocampal and retrosplenial connections of rat posterior parietal cortex

et al. 2017

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The posterior parietal cortex has been implicated in spatial functions, including navigation. The hippocampal and parahippocampal region and the retrosplenial cortex are crucially involved in navigational processes and connections between the parahippocampal/retrosplenial domain and the posterior parietal cortex have been described. However, an integrated account of the organization of these connections is lacking. Here we investigated parahippocampal connections

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Excitatory Postrhinal Projections to Principal Cells in the Medial Entorhinal Cortex

Cited by 26 publications

References 66 publications

Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation

Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation

Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex

Parahippocampal and retrosplenial connections of rat posterior parietal cortex

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