Excitation and depression of eccrine sweat glands by acetylcholine, acetyl‐β‐methylcholine and adrenaline

Collins, Kenneth J.; Sargent, Frederick; Weiner, J. S.

doi:10.1113/jphysiol.1959.sp006309

Cited by 53 publications

(28 citation statements)

References 22 publications

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“…It is clear that they reinforce one another, in that doses not large enough to cause desensitization are potent in enhancing ischaemic block. Desensitization itself does not involve a concomitant reduction of blood flow and it occurs regularly in the presence of vasodilatation (Collins et al 1959). Secondly, the effect on the sweat composition is different in the two cases.…”

Section: Discussionmentioning

confidence: 99%

“…With indirect heating we cannot attribute the failure to the nerve or to the gland cell alone, but from the results with direct stimulation it follows that the depression must at least be partly in the gland itself. The test doses used to elicit responses during ischaemia are well below the doses required to 'desensitize' the glands (Collins et al 1959).…”

Section: Discussionmentioning

confidence: 99%

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The effect of arterial occlusion on sweat‐gland responses in the human forearm

Collins¹,

Sargent²,

Weiner³

1959

The Journal of Physiology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of arterial occlusion on sweat‐gland responses in the human forearm

Collins¹,

Sargent²,

Weiner³

1959

The Journal of Physiology

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“…Although the response of the sweat glands to intradermal injections of acetylcholine and related compounds has in the past been the subject of numerous studies (for a review see Randall & Kimura, 1955), the only systematic investigation of the effects of different concentrations of these substances has been of high doses of acetylcholine and acetyl-/1-methylcholine (methacholine) by Collins, Sargent & Weiner (1959). Curves relating responses to low doses of these drugs have not been constructed, and threshold doses have only been assessed roughly (Chalmers & Keele, 1951;Collins, Crockford & Weiner, 1965).…”

Section: Introductionmentioning

confidence: 99%

Factors affecting the quantitative response of human eccrine sweat glands to intradermal injections of acetylcholine and methacholine

Foster¹

1971

The Journal of Physiology

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SUMMARY1. Using a ventilated capsule in conjunction with an infra-red water vapour analyser, and an indwelling intradermal needle, quantitative studies were made relating the magnitude of the sweat responses to the doses of acetylcholine or methacholine.2. Acetylcholine dose-response curves were constructed, and from these curves the threshold dose was defined. The threshold was similar in all subjects (10-3+S.E. 10-4tg/0 1 ml.).3. Factors affecting the acetylcholine dose-response curves were studied.Optimum conditions for stimulation in all subjects occurred using a capsule of 063 cm diameter,. injection volume of 0-1 ml. and a solution temperature of 370 C. When the skin temperature was 360 C the maximal acetylcholine response was then the same as the maximal thermal response.4. No change in the acetylcholine dose-response curves occurred with repeated determinations at the same site on the same occasion.5. The dose-response relationship for methacholine was similar to that for acetylcholine. The methacholine response was, however, more prolonged and so the volumes secreted were greater.

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“…Similar patterns of evaporative loss have been found in some wild East African bovids (Robertshaw & Taylor, 1969). A prominent feature of sweating in sheep and goats is the rapid decline in the amount of sweat produced at each discharge, an apparent 'fatigue' (Robertshaw, 1968 gland function has been noted in man after prolonged exposure to hot humid conditions and also after repeated administration of acetyl-/5-methylcholine (Thaysen & Schwartz, 1955; Collins, Sargent & Weiner, 1959). It can also be produced in a localized area of skin by preventing the evaporation of sweat and it has been suggested that sweat gland 'fatigue' in man is caused by hydration of the skin and obstruction of the sweat gland ducts.…”

Section: Introductionmentioning

confidence: 53%

Studies on the nature of sweat gland ‘fatigue’ in the goat

Jenkinson¹,

Robertshaw²

1971

The Journal of Physiology

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1. The nature of the ‘fatigue’ of sweating that occurs in the goat upon exposure to environmental conditions of 40° C/26° C (dry bulb/wet bulb) has been examined. 2. Heat exposure activated all the sweat glands and the decrement in sweating which occurred was due to a decline in the amount of sweat produced by each gland. 3. The decline in sweating activity was associated with a decrease in sweat gland volume and a thickening of the glandular wall. The restoration of sweat gland function took approximately 5‐6 hr after removing the animal from the hot environment but the restoration of sweat gland volume took longer. 4. The volume of sweat produced was greater than the decrease in sweat gland volume and it is concluded that ‘fatigue’ is due to the rate of expulsion exceeding the rate of sweat production. 5. Repeated intravenous injections of adrenaline at 40° C resulted in a decline in sweat output and reduced the normal glandular response to heat exposure.

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Excitation and depression of eccrine sweat glands by acetylcholine, acetyl‐β‐methylcholine and adrenaline

Cited by 53 publications

References 22 publications

The effect of arterial occlusion on sweat‐gland responses in the human forearm

The effect of arterial occlusion on sweat‐gland responses in the human forearm

Factors affecting the quantitative response of human eccrine sweat glands to intradermal injections of acetylcholine and methacholine

Studies on the nature of sweat gland ‘fatigue’ in the goat

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