Excimer Laser-produced Biodegradable Photopolymer Scaffolds Do Not Induce Immune Rejection In Vivo

Abstract

High power ultrafast lasers are nowadays able to provide high ablation rates and meet the technical requirements and performances needed for many industrial applications. However depositing more energy into the target may induce heat accumulation, and consequently enhances the ablation efficiency as well as introduces some detrimental effect on the processing quality. So, the key issue is to improve throughput while maintaining the processing quality and preventing from any deformation of the work piece. In this paper we present some comparative results on surface ablation of Aluminum, Copper, Molybdenum and stainless steel in both picosecond and femtosecond regimes. Trials have been performed using two high power Yb-doped fibre ultrafast lasers which are tunable in pulse duration (350 fs to 10 ps, up to 20 W). Samples have been characterized with confocal microscopy and scanning electron microscopy. We discuss the effect of pulse duration, repetition rate, fluence and energy dose per mm on ablation efficiency, processing quality and ripples formation.

Nanocomposite scaffold fabrication by incorporating gold nanoparticles into biodegradable polymer matrix: Synthesis, characterization, and photothermal effect

“…Following a previous work [19][20][21], the laser parameters have been adjusted to achieve a uniform layer thickness with the SL process. Any change in the resin absorption, and therefor the 308 nm laser penetration depth in the resin, is directly related to the increased nanoparticle concentration in the blend.…”

“…The geometry of the fabricated scaffolds is defined by a set of interchangable masks and various laser and resin parameters [15], e.g., the photoinitiator concentration [19,20], the number of pulses [19,20], or the pulse fluence [21].…”