Excimer laser angioplasty in acute myocardial infarction (the CARMEL multicenter trial)

Topaz, On; Ebersole, Douglas G.; Das, Tony; Alderman, Edwin L.; Madyoon, Hooman; Vora, Kishor; Baker, John D.; Hilton, David; Dahm, Johannes B.

doi:10.1016/j.amjcard.2003.11.050

Cited by 117 publications

(68 citation statements)

References 27 publications

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“…The patient reported by Daya et al [8] underwent emergency surgery due to left main thrombosis with acute ST segment elevation myocardial infarction and suffered acute pulmonary embolism in the early postoperative period. Knowing the success of excimer laser in the removal of extensive thrombus [9], we decided to treat our patient by laser. The case reported by Michalis et al underwent primary angioplasty for the totally occluded right coronary artery, and abciximab treatment for 5 days resulted in complete resolution of the thrombus seen in left main and LAD.…”

Section: Discussionmentioning

confidence: 99%

Left main coronary thrombosis with essential thrombocythemia

Nurkalem

Uslu

Görgülü

et al. 2006

J Thromb Thrombolysis

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Essential thrombocythemia is a disorder that causes persistent increase in the platelet count. The disease is associated with an elevated risk of thrombosis. A 71-year-old woman was diagnosed with left main coronary thrombosis after an angiogram due to stable angina. One week before the angiogram was taken the patient had also been diagnosed with essential thrombocythemia. After appropriate medical treatment for 5 days the patient underwent an excimer laser treatment, which failed in dissolving the thrombus. Before the patient underwent coronary surgery, thrombopheresis was performed in order to reduce the platelet count. After a successful coronary operation the patient improved completely.

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Section: Discussionmentioning

confidence: 99%

Left main coronary thrombosis with essential thrombocythemia

Nurkalem

Uslu

Görgülü

et al. 2006

J Thromb Thrombolysis

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show abstract

“…At first, the guiding ment of AMI by achieving maximum thrombus dissolution in lesions with extensive thrombus burden, significant increase in minimal luminal diameter, adequate restoration of antegrade Thrombolysis In Myocardial Infarction (TIMI) flow in the infarct-related artery, and a very low rate of distal embolization. 11 In the present study, we evaluated the safety and efficacy of ELCA as an adjunct to primary PCI in patients with ACS and compared the success rate, tissue-level perfusion, and shortterm outcomes following ELCA with those of manual thrombus aspiration.…”

Section: Pre-and Post-procedures Management and Pcimentioning

confidence: 99%

Vaporizing Thrombus With Excimer Laser Before Coronary Stenting Improves Myocardial Reperfusion in Acute Coronary Syndrome

Shishikura

Otsuji

Takiuchi

et al. 2013

Circ J

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“…This wavelength is well absorbed within atherosclerotic material with a shallow penetration depth of only 35-50 mm [20] which enables precise control of energy and ensures debulking without plaque disintegration. In 151 patients with atherosclerotic/thrombotic coronary lesions, excimer laser debulking caused distal embolization in only 1 (0.6%) patient [21]. Importantly, the excimer laser facilitates removal of the thrombus which frequently accompanies atherosclerotic plaques.…”

Section: Discussionmentioning

confidence: 99%

“…This has been validated in patients with acute myocardial infarction or unstable angina pectoris whereby quantitative analysis by an independent core laboratory demonstrated 96% reduction of thrombus burden with the laser emission in the acute myocardial infarction group and 97% reduction in the unstable angina group [22]. Furthermore, it appears that the larger the thrombus content, the higher the yield of the laser as a thrombectomy device [21]. It also suppresses platelet aggregation (''stunned platelet phenomenon'' [23]) thereby reducing their adverse effect on the revascularization process.…”

Section: Discussionmentioning

confidence: 99%