Excessive morbidity resulting from the prevention of intestinal adhesions with steroids and antihistamines

Separately and synergistic effects of taurolidine and icodextrin in preventing intraabdominal adhesions

“…[12,13] Also, corticosteroids have been administered for preventing adhesions considering their suppressive effects against inflammatory response but have been found to be insufficient with low doses and serious side effects have been found with high doses. [14,15] Several pharmacological agents, such as high doses of vitamin E and simvastatin, were discovered to have a high efficacy in adhesion prevention. [16][17][18] Taurolidine is an antimicrobial agent used for intra-abdominal adhesion formation and sepsis prevention in experimental and clinical trials.…”

“…Pharmacological agents, such as corticosteroids and vitamin E, has adhesion preventive effects at high doses. [14][15][16][17] Future studies may show similar impacts of taurolidine and icodextrin. In literature, there is a study in which in 2 ml (0.04 g) of taurolidine 2% solution has been used as an adhesion preventative.…”

The Effect of Tenoxicam on Intraperitoneal Adhesions and Prostaglandin E2 Levels in Mice

“…Using steroids and NSAIDs for the prevention of IAA at the first formation step has gained popularity (17)(18)(19). However, the risk of infection and wound healing problems due to large-dose steroid use are the major drawbacks of this treatment (21). However, the risk of infection and wound healing problems due to large-dose steroid use are the major drawbacks of this treatment (21).…”

Preoperative and Postoperative Management of the Patient Undergoing Infertility Surgery

“…59,60 The steroids have further lowered the resistance of organisms to infection, and animals receiving glucocorticoids for the reduction of adhesions have succumbed to infection. 53,57 Despite known risks and absence of controlled studies supporting their use, steroids are still extensively used by most infertility surgeons.…”