Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity

Abstract

Objective: Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. Besides, potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range. Methods: Lipid profile, body mass index (BMI), biochemical measurements, and carotid intima-media thickness (cIMT) were obtained in this cross-sectional study with 899 asymptomatic individuals. HDL functions were measured in a subgroup (n=101). Results: Individuals with increased HDL-C had an attenuated increase in cIMT with elevation of BMI. CEC, HDL-C, HDL size and HDL-antioxidant activity were negatively associated with cIMT. BMI was inversely associated with HDL-mediated inhibition of platelet aggregation and CEC, but surprisingly it was directly associated with the antioxidant activity. Thus, even in non-obese, non-diabetic individuals, increased BMI is associated with a wide change in protective functions of HDL, reducing CEC and increasing antioxidant activity. In these subjects, decreased HDL concentration, size or function are related to increased atherosclerotic burden. Conclusion: Our findings demonstrate that in non-obese, non-diabetic individuals, the increasing values of BMI are associated with impaired protective functions of HDL and concomitant increase in atherosclerotic burden.

Machine-learning-based analysis of the sensitivity and specificity on lipid-lowering effect of one-month-administered statins

“…Additionally, we found that HDL was positively associated with total cholesterol and hipline, but negatively associated with body weight, which was not echoed by the evidence that the correlation between HDL and total cholesterol was not significant in Japan and South Korea. [33] In a previously reported study, HDL and hipline were found to be reduced with acupuncture, which indirectly reflected the positively correlation of HDL with hipline, [34] and in another study, increased body weight would impair the protective functions of HDL, [35] and which supported our finding that HDL was negatively associated with body weight.…”

BMI modifies HDL-C effects on coronary artery bypass grafting outcomes

“…Furthermore, BMI was inversely related to HDL-C activity in inhibiting platelet aggregation and cholesterol efflux capacity. Taken together, this study suggested that the increase in BMI was linked to impaired cardioprotective functions of HDL-C and a concomitant increase in atherosclerosis [32]. Furthermore, an inverse correlation between serum HDL-C concentration and stroke has been reported among those with BMI < 24 kg/m 2 ; however, this finding no longer proved true for patients with BMI ≥ 24 kg/m 2 [33].…”

Scavenger Receptor BI Induced by HDL From Coronary Heart Disease May Be Related to Atherosclerosis

“…Then, these HepG2 cells were seeded at a density of 5 × 10 5 /well on 2 6-well plates, and grown to 70%-80% confluence for 24 hours before adding the extracted 50 µg/ml of HDL. 7…”