Excess mortality following hip fracture: a systematic epidemiological review

Abstract

This systematic literature review has shown that patients experiencing hip fracture after low-impact trauma are at considerable excess risk for death compared with nonhip fracture/community control populations. The increased mortality risk may persist for several years thereafter, highlighting the need for interventions to reduce this risk.Patients experiencing hip fracture after low-impact trauma are at considerable risk for subsequent osteoporotic fractures and premature death. We conducted a systematic review of the literature to identify all studies that reported unadjusted and excess mortality rates for hip fracture. Although a lack of consistent study design precluded any formal meta-analysis or pooled analysis of the data, we have shown that hip fracture is associated with excess mortality (over and above mortality rates in nonhip fracture/community control populations) during the first year after fracture ranging from 8.4% to 36%. In the identified studies, individuals experienced an increased relative risk for mortality following hip fracture that was at least double that for the age-matched control population, became less pronounced with advancing age, was higher among men than women regardless of age, was highest in the days and weeks following the index fracture, and remained elevated for months and perhaps even years following the index fracture. These observations show that patients are at increased risk for premature death for many years after a fragility-related hip fracture and highlight the need to identify those patients who are candidates for interventions to reduce their risk.

Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research

“…In addition, many (71%) were unable to live in conditions similar to those before the (77) These outcomes are similar to long-term outcomes for people with femoral neck fractures. (78)(79)(80)(81) A comprehensive review of 6409 femoral shaft fractures in Swedish inpatients showed a bimodal age distribution of incidence in both males and females, (82) similar to that reported by Singer and colleagues. (83) The age-specific incidence rates (per 100,000) for subtrochanteric fractures increased between the 65-and 85-year categories in both males and females in Iran, (84) in the United States, (85) and in the United Kingdom.…”

Hip fractures in extremely old patients

“…1,4,14,17 But, at the mean follow-up for 2.12 years showed 50% mortality in extremely old population, which is higher than elderly population reported in literature. 1,16,17 Females have higher risk of a hip fracture, 11 but males have higher mortality rates than females with a hip fracture. 24 In our study, extremely old patients showed no differences mortality rates between males and females (p ¼ 0.11).…”

“…This increased mortality in hip fracture patients has been documented in the first year after fracture and remains high in the subsequent years of followup. 16,17 The purpose of this study is report a less seen age-group of hip fracture patients and to investigate mortality, walking ability, functional status changes after surgical intervention.…”

Effect of bimagrumab on thigh muscle volume and composition in men with casting‐induced atrophy

“…In such individuals, an acute episode of disuse atrophy (e.g. a hip fracture) can lead to disability in terms of mobility, increased hospitalization, and loss of independence, which can culminate in premature mortality 11, 12. Hence, the timely recovery of muscle mass and strength is the key goal for the physical rehabilitation of patients with disuse atrophy.…”