Excess Lead in the Neural Retina in Age-Related Macular Degeneration

Erie, Jay C.; Good, Jonathan A.; Butz, John A.

doi:10.1016/j.ajo.2009.07.001

Cited by 26 publications

(20 citation statements)

References 21 publications

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“…These heavy metals have the same binding sites as Cu and Zn and can therefore displace these essential trace elements (Sarna et al, 1976;Hong et al, 2004;Hong and Simon, 2007). However, a correlation between loss of trace metals and an increase in heavy metal concentrations was not detected in (Erie et al, 2009) and also not in our results. Besides, heavy calcification of blood vessels, not only in the brain (e.g.…”

Section: The Role Of Iron and Heavy Metals In Amdcontrasting

confidence: 81%

“…Lead was associated with cataract in men (Schaumberg et al, 2004) and low-tension glaucoma in women (Yuki et al, 2009). Lead concentrations in the aqueous humor (Junemann et al, 2013) and the neural retina (Erie et al, 2009) of AMD patients were significantly increased compared to controls as investigated using ICP-MS. Besides iron (Hahn et al, 2003), the drusen of AMD patients also contained amyloid-b aggregates (Anderson et al, 2004) linking Alzheimer's disease to AMD.…”

Section: The Role Of Iron and Heavy Metals In Amdmentioning

confidence: 99%

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Iron accumulation in Bruch's membrane and melanosomes of donor eyes with age-related macular degeneration

Biesemeier

Yoeruek²,

Eibl

et al. 2015

Experimental Eye Research

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Section: The Role Of Iron and Heavy Metals In Amdcontrasting

confidence: 81%

Section: The Role Of Iron and Heavy Metals In Amdmentioning

confidence: 99%

Iron accumulation in Bruch's membrane and melanosomes of donor eyes with age-related macular degeneration

Biesemeier

Yoeruek²,

Eibl

et al. 2015

Experimental Eye Research

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“…For proper organ and human body function zinc is the most wanted ion because of its influence on vision, hearing, muscle function, and immune system response. It is very important to know that if too much lead is present, then zinc levels are decreasing [6]. It's worth pointing out that different lead and cadmium levels are also present in healthy young eyes than in elderly patient's eyes with macular degeneration.…”

Section: Metals and Sight Organmentioning

confidence: 99%

Occurrence and Exposure to Lead and Cadmium and Their Environmental Influence on Eyesight

Nelke¹,

Mulak²,

Łuczak³

et al. 2015

Pol. J. Environ. Stud.

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Heavy metal influence on the environment and humans is well known, although not all aspects are fully understood. Increased manufacturing and industrial growth without any proper approach for usage, distribution, and storage of heavy metals might lead to a very dangerous influence not only on an entire ecosphere, but also might affect human health. Because of different forms of exposure to heavy metals, different forms of after-exposure diseases might appear. Exposure by air, water, direct contact, and even by consumption -along with other less common ways of exposure -have been mentioned globally [1].Soil and water exposed to heavy metals results in both animal and plant metal poisoning. Humans at the end of the food chain are exposed on any long-or short-term influence of heavy metal poisoning [2]. Many variables are related to poison activity on humans and the environment. Factors such as age, coexisting other diseases, and time and type of exposure are very important. Different topics are related to the environment. Type of soil, insolation, and closure to any human habitats and other factors should always be considered when discussing heavy metal exposure. Accumulation of heavy metals is dangerous for the environment. A special focus should be particularly used in order to avoid improper heavy metal disposal and increase a safe and long-term method for waste storage [3]. In order to fully understand the impact of heavy metals on humans and the environment is unlikely to improve factory production and safety standards [4].Evaluate and describe briefly how lead and cadmium heavy metal exposure influences the sight organ and discuss whether it is a common or rare occurrence.Pol. J. Environ. Stud. Vol. 24, No. 4 (2015) AbstractNowadays heavy metals in the environment and everyday life are very common. Their usage and influence in industry is essential. Quite often not only the environment but also general human health might be impacted by their use and presence. Metal poisoning and its effect on living structures and tissues impacts their condition. The environment and every living species in it are heavily vulnerable to any heavy metal exposure and might lead to catastrophic natural disasters. In humans skin irritations and general diseases are not so common, but they do appear, and everyone should be aware of this. In this paper we focus on a very special topic related to heavy metal exposure to eyesight and their influence on this important organ. Lead and cadmium are the most common heavy metals used almost everywhere.

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“…Potential risk factors that suggest oxidative stress involvement for the pathogenesis of AMD include smoking, increased body mass index, sun exposure, and accumulation of iron, lead, or cadmium. [38][39][40] Toxic heavy metals are considered to be key for the excess production of free radicals, and their involvement with other age-related eye diseases has been observed, such as increased lead levels in glaucoma patients. 41 In the AREDS2 study, vitamins A, C, and E; zinc; copper; lutein; zeaxanthin; and eicosapentaenoic acid/ docosahexaenoic acid (EPA/DHA) were the major components of the antioxidative supplements.…”

Section: Oxidative Stress and Dry Eyementioning

confidence: 99%

The Antiaging Approach for the Treatment of Dry Eye

Tsubota

Kawashima

Inaba

et al. 2012

Cornea

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Dry eye is one of the most common eye disorders affecting millions of people. It causes ocular irritation or discomfort, and decreases functional vision, causing a dramatic deterioration in the quality of life. Although new treatments such as the P2Y2 agonist or cyclosporine eye drops have been developed and a certain level of patient satisfaction can now be obtained, no fundamental treatment has been developed. Currently, there is no therapy available to recover lacrimal function to its normal status. Recent progress in the understanding of aging has laid the foundations for a new way of thinking about intervention of the aging process. Because dry eye is accelerated by aging, a useful approach for the prevention or treatment of dry eye may be to interfere with the aging process. In the scientific community, there is a global consensus that calorie restriction can extend the life span of various kinds of animals, establishing an intervention to aging. Another important hypothesis believed to be involved in aging is the free radical theory. According to these theories, the aging process may be managed by controlling levels of calories or reactive oxygen species. In this review, these 2 important aging theories, calorie restriction and free radical aging, are examined, and we discuss how to apply these theories to the prevention and treatment of dry eye.

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Excess Lead in the Neural Retina in Age-Related Macular Degeneration

Cited by 26 publications

References 21 publications

Iron accumulation in Bruch's membrane and melanosomes of donor eyes with age-related macular degeneration

Iron accumulation in Bruch's membrane and melanosomes of donor eyes with age-related macular degeneration

Occurrence and Exposure to Lead and Cadmium and Their Environmental Influence on Eyesight

The Antiaging Approach for the Treatment of Dry Eye

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