Excess Dietary Aluminum Increases &lt;i&gt;Drosophila’s&lt;/i&gt;Rate of Aging

Massie, Harold R.; Williams, T. R.; Aiello, Valerie R.

doi:10.1159/000212714

Cited by 11 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of aluminum only to adult flies also reduced the life span of both males and females, exposed to 120 and 240 mg/kg of Al, although changes were not so dramatic like those caused by chronic aluminum exposure. In another study, it has also been found that Al decreases the life span of D. melanogaster by 20% when the dietary content of aluminum is 1× 10 −4 mol/L (Massie et al ., ). It turns out that a lower Al concentration (120 mg/kg) administrated for a short period, only during larval development, has a stimulating effect and increases the life span of males.…”

Section: Discussionmentioning

confidence: 97%

Drosophila melanogaster as a model system of aluminum toxicity and aging

et al. 2013

View full text Add to dashboard Cite

The aim of this study was to investigate the toxic effects of aluminum (Al) on the model organism-Drosophila melanogaster. The study is especially concerned with the effects of aluminum on the fruit fly's development, life span, and circadian rhythm in rest and activity. Flies were exposed to aluminum in concentrations from 40 to 280 mg/kg in rearing media or the flies were raised on control medium. Moreover, the life span of insects exposed to aluminum containing 40, 120, or 240 mg/kg of Al in the medium, only during their larval development, during the whole life cycle and only in their adult life was tested. To check if aluminum and aging cause changes in D. melanogaster behavior, the locomotor activity of flies at different ages was recorded. Results showed that aluminum is toxic in concentrations above 160 mg/kg in the rearing medium. Depending on Al concentration and time of exposure, the life span of the flies was shortened. At intermediate concentrations (120 mg/kg), however, Al had a stimulating effect on males increasing their life span and level of locomotor activity. At higher concentration the aluminum exposure increased or decreased the level of locomotor activity of D. melanogaster depending on age of flies. In addition, in the oldest insects reared on aluminum supplemented media and in mid-aged flies reared on the highest concentration of Al the daily rhythm of activity was disrupted.

show abstract

Section: Discussionmentioning

confidence: 97%

Drosophila melanogaster as a model system of aluminum toxicity and aging

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Al‐induced developmental abnormalities have also been demonstrated in both vertebrate and invertebrate model organisms. Rearing medium AlCl 3 concentrations more than 160 mg/kg were toxic for Drosophila melanogaster (Kijak, Rosato, Knapczyk, & Pyza, ; Massie, Williams, & Aiello, ). Additionally, depending on Al concentrations and duration exposure, both larvae and pupae viability decreased with developmental desynchronization and reduced life spans.…”

Section: Discussionmentioning

confidence: 99%

Aluminum toxicity related to SOD and expression of presenilin and CREB in Bombyx mori

Liu

Qian

Chao

et al. 2018

Arch Insect Biochem Physiol

View full text Add to dashboard Cite

Aluminum (Al) is an important environmental metal factor that can be potentially associated with pathological changes leading to neurotoxicity. The silkworm, Bombyx mori, is an important economic insect and has also been used as a model organism in various research areas. However, the toxicity of Al on silkworm physiology has not been reported. Here, we comprehensively investigate the toxic effects of Al on the silkworm, focusing on its effects on viability and development, superoxide dismutase (SOD) activity, and the expression of presenilin and cAMP response element-binding protein (CREB) in BmE cells and silkworm larvae. BmE cell viability decreased after treatment with aluminum chloride (AlCl ) in both dose- and time-dependent manners. When AlCl solution was injected into newly hatched fifth instar larvae, both larval weight gain and survival rate were significantly decreased in a manner correlating with AlCl dose and developmental stage. Furthermore, when BmE cells and silkworm larvae were exposed to AlCl , SOD activity decreased significantly relative to the control group, whereas presenilin expression increased more than twofold. Additionally, CREB and phosphorylated CREB (p-CREB) expression in the heads of fifth instar larvae decreased by 28.0% and 50.0%, respectively. These results indicate that Al inhibits the growth and development of silkworms in vitro and in vivo, altering SOD activity and the expressions of presenilin, CREB, and p-CREB. Our data suggest that B. mori can serve as a model animal for studying Al-induced neurotoxicity or neurodegeneration.

show abstract

“…Studies on Al toxicity have been mostly confined to mammals with scant information on birds [9] and poikilothermic vertebrates [10]. Similarly, even though an accumulation of Al with aging has been observed in fruit flies [11], rat tissues [12] and human brain [13] there is a lack of information regarding the age-related toxic effect of Al.…”

Section: Introductionmentioning

confidence: 99%

Age-Related Effect of Aluminium on the Catalase Activities of the Brains of Two Species of Poikilothermic Vertebrates

Jena

Nayak²,

Patnaik

2002

Gerontology

View full text Add to dashboard Cite

Background: Although aluminium (Al) has been implicated in various neuropathological states with aging due to its involvement in neurotoxicity, the exact role of the metal ion is still unclear. Objective: The aim of the present study is to ascertain whether the antioxidant enzymes of the brain protecting from oxidative damages which accumulate with aging are regulated by Al in an age-dependent manner. Method: The inhibitory effect of Al on the catalase activity of brain homogenates of two species of poikilothermic vertebrates was studied in vitro using a spectrophotometric method. Results: At a final concentration of 666 µM, the metal ion inhibited the enzyme activity of the brain in both species. In fish brain the degree of inhibition was not age-dependent. On the other hand, the rate of inhibition increased between young and middle-aged lizards followed by a decline in the old counterparts. Conclusion: Al inhibits catalase activity but this effect may not be a major contributing factor in the aging of the brain in the two species capable of maintaining their antioxidant capacity until old age.

show abstract

Excess Dietary Aluminum Increases <i>Drosophila’s</i>Rate of Aging

Cited by 11 publications

References 8 publications

Drosophila melanogaster as a model system of aluminum toxicity and aging

Drosophila melanogaster as a model system of aluminum toxicity and aging

Aluminum toxicity related to SOD and expression of presenilin and CREB in Bombyx mori

Age-Related Effect of Aluminium on the Catalase Activities of the Brains of Two Species of Poikilothermic Vertebrates

Contact Info

Product

Resources

About