<i>Drosophila melanogaster</i> as a model system of aluminum toxicity and aging

Kijak, Ewelina; Rosato, Ezio; Knapczyk, Katarzyna; Pyza, Elżbieta

doi:10.1111/1744-7917.12017

Cited by 30 publications

(22 citation statements)

References 36 publications

(39 reference statements)

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“…The toxicity of Al is remarkable to aquatic animals in acidic waters, especially in lakes and rivers. High concentrations of Al may cause increasing or decreasing levels of locomotor activity in insects [45].…”

Section: Discussionmentioning

confidence: 99%

Environmental-Friendly Contamination Assessment of Habitats Based on the Trace Element Content of Dragonfly Exuviae

Simon

Tóthmérész²,

Kis

et al. 2019

Water

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We tested the usefulness of exuviae as an environmentally friendly method for exploring the variability of the trace element contents of protected insect populations without killing specimens. It is a notable characteristic of dragonflies that they are good ecological indicators for both aquatic and terrestrial habitat quality. Thus, we investigated the trace element accumulation in different stages of dragonflies: larva, exuvia, and adult. Using microwave plasma atomic emission spectrometry (MP-AES), we analysed the concentrations of Al, Ba, Cr, Cu, Fe, Mn, Pb, Sr and Zn. We found that the trace element contents of exuviae are a good proxy of the trace element contents of both the larvae and the adults. We conclude that exuvia is useful for assessing the environmental health of aquatic ecosystems. It is an environmentally friendly method and it can be used even in the case of protected dragonfly species. 2 of 10 their larvae stage in aquatic habitats and use a wide range of terrestrial habitats as adults, and they are important predators in aquatic and terrestrial ecosystems [19][20][21][22].Aquatic insects can accumulate elements such as Al, Cd, Cr, Cu, Fe, Mg, Mn and Zn from sediment and from food [23]. In aquatic insects, the concentrations of Hg, Cd, Ni, Cr, As, Pb, Cu, Ti, Zn and Mn change with size, life cycle stages and different bioaccumulation patterns [24]. There are only a few reports dealing with the changes in trace element concentration during different developmental stages [25]. Among these stages, dragonfly adults increase their bioaccumulation potential because they feed on other invertebrates [21]. Larvae and exuviae are also useful to detect accumulation and element bioavailability [24].Accumulated trace metals can be detoxified and excreted in aquatic invertebrates [26]. Trace elements become associated with the calcium in the exoskeleton matrix. They may be absorbed on the surface of the exoskeleton or bind to the inner exoskeleton matrix after uptake [27,28]. During metamorphosis, the protein and lipid content alter; stored resources and decomposing cellular structures are metabolized. Metamorphosis influences metal concentration by metal excretion; thus, the concentration of these metals decreases in the body. Mechanisms of contaminant loss include the exoskeleton as exuvia; the importance of this pathway also depends on the contaminant [21,29,30]. The decontamination process under conditions of an intensive intake of trace elements to an organism is the production of excrement [27].Earlier studies demonstrated that the river clubtail (Gomphus flavipes (Stylurus flavipes)) (Odonata: Gomphidae; Linnaeus, 1758) is a sensitive indicator of pollution [31,32]. This species is a characteristic of large lowland rivers in Europe [33,34] and in Hungary [35]; thus, this species was chosen for our study. The aim of our study was to investigate the trace element accumulation in different stages of the dragonfly to test whether the exuviae may be used as a tool for contamination level assessment. We an...

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Section: Discussionmentioning

confidence: 99%

Environmental-Friendly Contamination Assessment of Habitats Based on the Trace Element Content of Dragonfly Exuviae

Simon

Tóthmérész²,

Kis

et al. 2019

Water

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“…Havens (1993) ) on aquatic invertebrates: it was found that aluminium significantly decreased the survival rate of Gyraulus, Hyalella and Chironomida, at the same time, the survival rate of Enallagma and Caenis at low pH (4-5) improved due to Al. Kijak et al (2014) studied the toxic impact of aluminium on Drosophila melanogaster (Meigen, 1830). The flies were exposed to aluminium at concentrations from 40 to 280 mg kg -1 in the food substrate.…”

Section: Discussionmentioning

confidence: 99%

The impact of some inorganic substances on change in body mass of Tenebrio molitor (Coleoptera, Tenebrionidae) larvae in a laboratory experiment

Мартынов

Brygadyrenko

2018

Folia Oecologica

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Martynov, V.O., Brygadyrenko, V.V., 2018. The impact of some inorganic substances on change in body mass of Tenebrio molitor (Coleoptera, Tenebrionidae) larvae in a laboratory experiment. Folia Oecologica, 45: 24-32.Addition of low concentrations of metal ions to the diet of saprophagous insects can impact on their metabolism over a short period of time, causing an increase or decrease in their body mass. This article presents a 14-day laboratory experiment evaluating the changes in the body mass of larval stage 3 of Tenebrio molitor (Linnaeus, 1758) induced by adding different inorganic substances (350 mg kg -1 of dry fodder) to the diet of the larvae. Following the addition of inorganic substances to the fodder, the most marked differences compared to the control were observed in the groups which consumed substrate with lead nitrate (the mass of the larvae increased on average by 102.6% compared to increase in mass in the control variant of the experiments), cobalt nitrate (by 96.9%), calcium chloride (by 89.1%) sodium triphosphate (by 86.0%), zinc chloride (by 83.5%). A nonsignificant effect (a tendency of increase in the body mass) on T. molitor larvae was caused by manganese sulfate (by 57.8%), aluminium nitrate (by 57.3%), iron oxide (by 51.5%), barium nitrate (by 47.9%), orthophosphoric acid (by 47.4%), manganese chloride (by 46.5%), calcium carbonate (by 27.7%), iron sulfate (by 24.2%) and ammonium heptamolybdate (by -7.5%). Therefore, 5 out of the 15 studied inorganic substances significantly stimulated the increase in the body weight of T. molitor larvae, and 7 manifested these capacities at the level of tendency (stimulated an increase in body weight averaging 43-58% over the 14-day experiment). The obtained data indicate a necessity for further study on the impact of inorganic pollutants on different stages of insects.

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“…Aluminum has been implicated as a neurotoxicant and a possible factor in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), PD and AD, which as previously mentioned have strong circadian components (Rodella et al, 2008). While few studies of the effect of aluminum on human sleep and circadian rhythms have been reported, evidence from the fruit fly Drosophila melanogaster showed that in addition to shortening the lifespan of the flies, aluminum exposure influenced the level and rhythm of daily locomotion (Kijak et al, 2014). Given the connection to human neurodegenerative disease with circadian components, this finding in flies suggests that further observation into human aluminum exposure and further research into circadian mechanisms is warranted.…”

Section: Introductionmentioning

confidence: 99%

Metals and Circadian Rhythms

Parmalee

Aschner

2017

Advances in Neurotoxicology

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Circadian rhythms describe the behavioral and physiological changes that occur in living organisms in order to attune to a 24 hour cycle of day and night. The most striking aspect of circadian function is the sleep-wake cycle, however many other physiological processes are regulated in 24 hour oscillations, including blood pressure, body temperature, appetite, urine production, and the transcription and translation of thousands of circadian dependent genes. Circadian disruption and sleep disorders are strongly connected to neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease as well as others. Metal exposures have been implicated in neurodegenerative diseases, in some cases involving metals that are essential micronutrients but are toxic at high levels of exposure (such as manganese, copper, and zinc), and in other cases involving metals that have no biological role but are toxic to living systems (such as lead, mercury, and aluminum). In this review, we examine the evidence for circadian and sleep disorders with exposures to these metals and review the literature for possible mechanisms. We suggest that giving the aging population, the prevalence of environmental exposures to metals, and the increasing prevalence of neurodegenerative disease in the aged, more research into the mechanisms of circadian disruption subsequent to metal exposures is warranted.

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Drosophila melanogaster as a model system of aluminum toxicity and aging

Cited by 30 publications

References 36 publications

Environmental-Friendly Contamination Assessment of Habitats Based on the Trace Element Content of Dragonfly Exuviae

Environmental-Friendly Contamination Assessment of Habitats Based on the Trace Element Content of Dragonfly Exuviae

The impact of some inorganic substances on change in body mass of Tenebrio molitor (Coleoptera, Tenebrionidae) larvae in a laboratory experiment

Metals and Circadian Rhythms

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