Excess accumulation of body fat is related to dyslipidemia in normal-weight subjects

Abstract

OBJECTIVE: To assess the relationship of fat mass (FM) and its distribution to hypertension and dyslipidemia in normal-weight Japanese individuals. DESIGN: Cross-sectional study. SUBJECTS: Apparently healthy Japanese subjects with a body mass index (BMI) between 20 and 23.5 kg/m 2 (265 males and 741 females, age 21-69 y). MEASUREMENTS: BMI, waist circumference (WC), waist-hip ratio (WHR), systolic and diastolic blood pressure, serum levels of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C) and triglyceride (TG) were measured. Low-density lipoprotein-cholesterol (LDL-C) was calculated by the Friedewald formula. Percentage fat mass (%FM) and trunk fat mass-leg fat mass ratio (FM trunk /FM legs ) were obtained by dual-energy X-ray absorptiometry. RESULTS: WC, WHR, %FM and FM trunk /FM legs were significantly correlated with TC, LDL-C, HDL-C and TG with the tendency of FM trunk /FM legs to show the strongest correlations. For %FM and FM trunk /FM legs in both sexes, odds ratios (ORs) of the third tertiles with respect to the first tertiles increased for LDL-C elevation, TG elevation and dyslipidemia. In males, ORs of the third tertiles of WC were significantly high for LDL-C elevation and dyslipidemia whereas those of WHR were high for TG elevation and dyslipidemia. ORs of the third tertiles of WC and WHR were significantly high for TG elevation in females. BMI was not associated with the risk of abnormal lipid levels. ORs for hypertension showed significant increases in none of the variables of obesity. CONCLUSIONS: Excess accumulation of FM, especially to the upper body, was related to dyslipidemia in normal-weight subjects. Simple anthropometric variables, WC and WHR, may be useful for screening and management of dyslipidemia in these subjects.

Favourable association of leg fat with cardiovascular risk factors

“…Waist circumference (WC) and waist-hip ratio have been widely used as simple and inexpensive indices for screening one's fat distribution [1][2][3][4]. Although the assumption that WC reflects trunk fat mass (FM) or visceral FM is relatively straightforward [5][6][7], the significance of hip circumference (HC) is not clear.…”

“…Amongst them, 4256 subjects (1249 men and 3007 women, age 20-79 years) were analysed in the present study. Part of the subjects has been analysed in our previous studies [4,17,19]. Those with a history of cardiac, pulmonary, renal or malignant disease and those who were currently taking medications were excluded from the study.…”

Association between Abdominal Wall Fat Index on Ultrasonography and Carotid Atherosclerosis in Non-obese Men

“…However, the degree of obesity is not necessarily correlated with the severity and frequency of such disorders. Ito et al (1) reported that excess accumulation of fat mass, especially in the upper body, was related to dyslipidemia in normal-weight Japanese individuals. Moreover, intra-abdominal adiposity has been found to be associated with glucose intolerance, elevated triglyceride (TG), low HDL cholesterol (HDL-C) levels, and hypertension in both clinical (2) and population-based prospective cohort studies (3).…”

“…Alternative noninvasive methods to quantify regional adiposity have been used in clinical and epidemiological studies. The use of waist-to-hip ratio (WHR) or waist circumference (1), and abdominal fat deposition by ultrasonography (6,(7)(8)(9) as predictors of atherosclerotic risk have been reported.…”

Influence of apolipoprotein-E gene on lipid profile, physical activity and body fat relationship. DOI:10.5007/1980-0037.2012v14n2p221

“…As concentrações de CT, triglicerídeos e LDL correlacionam-se positivamente com a gordura corporal, enquanto as de HDL, negativamente 12 , sendo que indivíduos com sobrepeso e obesidade apresentam maiores concentrações de triglicerídeos, LDL e CT 13 . Ademais, o acúmulo excessivo de gordura corporal está associado à presença de dislipidemias 14 . Somado a isso, o excesso de adiposidade corporal acomete uma parcela significativa da população, haja vista que, em torno de 47,8% das crianças, 25,4% dos adolescentes e 63,8% dos adultos 15 encontram-se em estado de sobrepeso/obesidade.…”