Example of a Thimerosal‐Dependent Antibody without Apparent Blood Group Specificity

Mason, James; Osborne, Pamela T.; Hall, AG; Skolnik, Judy S.; Woods, Laura Lee; Wood, Catherine L.; Pierce, Steven R.; Beck, Malcolm L.

doi:10.1111/j.1423-0410.1985.tb00188.x

Cited by 11 publications

(1 citation statement)

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“…Several chemicals that are used as preservatives in commercial serological reagents, such as albumin, EDTA, citrate and low-ionic strength saline, have been implicated in causing anomalous blood grouping [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. This phenomenon is characterised by the discrepancy between reactions of serum samples with RBCs in the presence and in the absence of the causative chemical.…”

Section: Additive-dependent Agglutinationmentioning

confidence: 99%

Clinically and/or Serologically Misleading Findings Surrounding Immune Haemolytic Anaemias

Salama¹

2015

Transfus Med Hemother

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Autoimmune haemolytic anaemias (AIHAs) are well-characterized disorders. They can be differentiated from one another and from other non-immune haemolytic anaemias by clinical, laboratory and serological testing. However, several misleading clinical presentations and/or serological findings may result in misinterpretation, delay and/or misdiagnosis. Such failures are avoidable by adequate clinical and serological experience of the responsible physicians and serologists or, at least, by an optimised bidirectional communication. As long as this has not been achieved, unpleasant failures are to be expected. A true diagnosis of AIHA can neither be verified by clinical nor serological findings alone. Thus, a collective clinical and serological picture remains obligatory for fulfilling the criteria of optimal diagnosis and therapy. Ultimately, the majority of pioneer scientific and practical work in this field stems from scientists who were simultaneously involved in both the clinic and serology.

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