Examining the use of tramadol hydrochloride as an antidepressant.

Barber, J.W.

doi:10.1037/a0022721

Cited by 61 publications

(50 citation statements)

References 82 publications

(111 reference statements)

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“…The antidepressant effects of many analgesic drugs have been observed in clinical and experimental animal studies [21][22][23][24][25][26][27]. Tramadol and some opioid agonists have been declared to improve depressive symptoms [22,23].…”

Section: Discussionmentioning

confidence: 99%

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Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Kıroğlu¹,

Demirkol²,

Berktaş³

et al. 2016

CIM

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Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences Abstract Purpose: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects.Methods: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks. Dipyrone was administered intraperitoneally beginning from the third week. Splash, rota-rod (RR) and forced swimming (FST) tests were performed at the seventh week as behavioural tests to evaluate the antidepressant-like effects of dipyrone. Coat state score (CSS) and weights of animals were recorded at seventh weeks. Results were analyzed using one or two-way ANOVA followed by the Bonferonni post hoc test.Results: Weight of UCMS-exposed mice did not change compared with controls; however, significant changes were observed in CSS in both sexes of stressed mice (p<0.05). RR latency decreased and immobility time enhanced in FST test in both sexes of stressed mice (p<0.05). Grooming behaviour was not different between the groups in female mice, but different in male mice in the splash test. Dipyrone did not produce a significant change in CSS in the UCMS-exposed group but reversed the latency time and immobility time to normal values in both sexes of mice and augmented the number of grooming behaviour only in stressed male mice. Conclusion:These results indicate that dipyrone produce antidepressant-like effects to some symptoms of UCMS according to gender.SUPPLEMENT

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Section: Discussionmentioning

confidence: 99%

“…Tramadol and some opioid agonists have been declared to improve depressive symptoms [22,23]. Celecoxib and piroxicam have been shown to display antidepressant effect in human and animal studies [8,[24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Kıroğlu¹,

Demirkol²,

Berktaş³

et al. 2016

CIM

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“…It is an analgesic with therapeutic effects via activation of opioid receptors and elevation of the plasma levels of serotonin and norepinephrine (16) . However, its use is not recommended since there is no scientific evidence regarding its effectiveness and safety in children (17) .…”

Section: Discussionmentioning

confidence: 99%

Analgesia e sedação durante a instalação do cateter central de inserção periférica em neonatos

Costa

Bueno

Oliva

et al. 2013

Rev. esc. enferm. USP

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Objetivou-se caracterizar as estratégias de analgesia e sedação em neonatos submetidos à instalação do cateter central de inserção periférica (CCIP) e relacioná-las ao número de punções venosas, duração do procedimento e posicionamento da ponta do cateter. Estudo transversal com coleta prospectiva de dados, realizado em uma unidade de cuidados intensivos neonatais de um hospital privado na cidade de São Paulo, no período de 31 de agosto de 2010 a 01 de julho de 2011, em que foram avaliadas 254 inserções do CCIP. A adoção de estratégias analgésicas ou sedativas ocorreu em 88 (34,6%) instalações do cateter e não esteve relacionada ao número de punções venosas, duração do procedimento ou posicionamento da ponta do cateter. As estratégias mais frequentes foram a administração endovenosa de midazolam em 47 (18,5%) e fentanil em 19 (7,3%) inserções do cateter. Recomenda-se maior adoção de estratégias analgésicas antes, durante e após o procedimento.

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“…Then, the Mannich base (3a-3d) (1 mmol) solved in anhydrous THF was added drop-wise to the reaction. After stirring for 3 h, the reaction was quenched with a saturated NH 4 Cl aqueous solution. The mixture was diluted with water and extracted with CHCl 3 (3×15 mL).…”

Section: Methodsmentioning

confidence: 99%

“…Tramadol, which was launched in 1977, is a fully synthetic opioid pain medication used to treat moderate to severe pain, both acute and chronic [1] . In addition, it has also been used to treat depression, postherpetic neuralgia, diabetic neuropathy premature ejaculation [2][3][4][5][6][7][8] . Tramadol displays some weak side effects, including nausea, dizziness, indigestion and abdominal pain in individual patients [9,10] .…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands

Shen

Qian

et al. 2015

Acta Pharmacol Sin

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Aim: Tramadol is an atypical opioid analgesic with low potential for tolerance and addiction. However, its opioid activity is much lower than classic opiates such as morphine. To develop novel analgesic and further explore the structure activity relationship (SAR) of tramadol skeleton. Methods: Based on a three-dimensional (3D) structure superimposition and molecular docking study, we found that M1 (the active metabolite of tramadol) and morphine have common pharmacophore features and similar binding modes at the μ opioid receptor in which the substituents on the nitrogen atom of both compounds faced a common hydrophobic pocket formed by Trp2936.48 and Tyr3267.43. In this study, N-phenethylnormorphine was docked to the μ opioid receptor. It was found that the N-substituted group of N-phenethylnormorphine extended into a hydrophobic pocket formed by Trp2936.48 and Tyr3267.43. This hydrophobic interaction may contribute to the improvement of its opioid activities as compared with morphine. The binding modes of M1, morphine and N-phenethylnormorphine overlapped, indicating that the substituent on the nitrogen atoms of the three compounds may adopt common orientations. A series of N-phenylalkyl derivatives from the tramadol scaffold were designed, synthesized and assayed in order to generate a new type of analgesics. Results: As a result, compound 5b was identified to be an active candidate from these compounds. Furthermore, the binding modes of 5b and morphine derivatives in the μ opioid receptor were comparatively studied. Conclusion: Unlike morphine-derived structures in which bulky N-substitution is associated with improved opioid-like activities, there seems to be a different story for tramadol, suggesting the potential difference of SAR between these compounds. A new type of interaction mechanism in tramadol analogue (5b) was discovered, which will help advance potent tramadol-based analgesic design.

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Examining the use of tramadol hydrochloride as an antidepressant.

Cited by 61 publications

References 82 publications

Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Analgesia e sedação durante a instalação do cateter central de inserção periférica em neonatos

Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands

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