Examining the Three-Step Theory (3ST) of Suicide in a Prospective Study of Adult Psychiatric Inpatients

Tsai, Michelle; Lari, Harris; Saffy, Samantha; Klonsky, E. David

doi:10.1016/j.beth.2020.08.007

Cited by 13 publications

(15 citation statements)

References 50 publications

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“…This pattern held at both time points. Overall, results from this study align with previous findings supporting Steps 1 and 2 of the 3ST in undergraduate samples (Dhingra et al, 2018; Yang et al, 2018), an online community sample (Klonsky & May, 2015), and a psychiatric inpatient sample (Tsai et al, 2020).…”

Section: Discussionsupporting

confidence: 89%

“…These first two steps of the 3ST have been supported in multiple studies: a large online sample in the United States (Klonsky & May, 2015), a sample of undergraduate students in the United Kingdom (Dhingra et al, 2018), a sample of undergraduate students in China (Yang et al, 2018), and most recently, a sample of adult psychiatric inpatients (Tsai et al, 2020). Though results from these studies are promising, several limitations of studies to date must be addressed.…”

mentioning

confidence: 99%

“…Finally, previous research on the 3ST has largely been cross-sectional rather than longitudinal (but see Tsai et al, 2020). A cross-sectional design is reasonable for examining the validity of the first two steps of the 3ST given that these two steps explain the presence of current suicidal desire (Klonsky & May, 2015).…”

mentioning

confidence: 99%

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Examining suicidal desire through the lens of the three-step theory: A cross-sectional and longitudinal investigation in a community sample.

Pachkowski¹,

Hewitt²,

Klonsky³

2021

Journal of Consulting and Clinical Psychology

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This study supports the validity and predictive utility of two steps of the Three-Step Theory of suicide in a community sample of adults. Pain, hopelessness, and connectedness exhibited moderate to strong relationships to current and future suicidal desire in a manner predicted by the theory. Findings suggest that the Three-Step Theory may be a useful perspective for guiding conceptualization and mitigation of suicidal desire.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

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Examining suicidal desire through the lens of the three-step theory: A cross-sectional and longitudinal investigation in a community sample.

Pachkowski¹,

Hewitt²,

Klonsky³

2021

Journal of Consulting and Clinical Psychology

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“…In particular, the pathway associated with SCN genes seems to be involved in the biological processes of pain, especially in the development of inflammatory pain [65][66][67][68]. This could explain the link between these genes (and related pathways) and suicide risk, as pain is a robust predictor of suicidal desire [69].…”

Section: Molecular Pathway Analysismentioning

confidence: 99%

Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings

Lybech

Calabrò

Briuglia

et al. 2021

Genes

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Suicide in Bipolar Disorder (BD) is a relevant clinical concern. Genetics may shape the individual risk for suicide behavior in BD, together with known clinical factors. The lack of consistent replication in BD may be associated with its multigenetic component. In the present contribution we analyzed a sample of BD individuals (from STEP-BD database) to identify the genetic variants potentially associated with three different suicide-related phenotypes: 1) a feeling that the life was not worth living; 2) fantasies about committing a violent suicide; 3) previous attempted suicide. The sample under analysis included 1115 BD individuals. None of the SNPs reached genome-wide significance. However, a trend of association was evidenced for rs2767403, an intron variant of AOPEP gene, in association with phenotype #1 (p = 5.977 × 10−6). The molecular pathway analysis showed a significant enrichment in all the investigated phenotypes on pathways related to post synaptic signaling, neurotransmission and neurodevelopment. Further, NOTCH signaling or the γ-aminobutyric acid (GABA) -ergic signaling were found to be associated with specific suicide-related phenotypes. The present investigation contributes to the hypothesis that the genetic architecture of suicide behaviors in BD is related to alteration of entire pathways rather than single genes. In particular, our molecular pathway analysis points on some specific molecular events that could be the focus of further research in this field.

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“…As with the IPTS, however, interpersonal factors are central to one's vulnerability for suicide. There have been only three studies of the 3ST that included African American participants (Anestis et al 2018), Black participants (in the United Kingdom; Dhingra et al 2019), or African participants (in Canada; Tsai et al 2021); none conducted group analyses relevant to race and ethnicity or included adolescent participants.…”

Section: Theories Of Suicide Revisitedmentioning

confidence: 99%

Suicide in African American Adolescents: Understanding Risk by Studying Resilience

Robinson

Whipple

Keenan

et al. 2022

Annu. Rev. Clin. Psychol.

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Historically, suicide rates for African American adolescents have been low,relative to rates for youth of other racial-ethnic backgrounds. Since 2001, however, suicide rates among African American adolescents have escalated: Suicide is now the third leading cause of death for African American adolescents. This disturbing trend warrants focused research on suicide etiology and manifestation in African American adolescents, along with culturally sensitive and effective prevention efforts. First, we revisit leading suicide theories and their relevance for African American adolescents. Next, we discuss health promotive and protective factors within the context of African American youth development. We also critique the current status of suicide risk assessment and prevention for African American adolescents. Then, we present a heuristic model of suicide risk and resilience for African American adolescents that considers their development within a hegemonic society. Finally, we recommend future directions for African American adolescent suicidology. Expected final online publication date for the Annual Review of Clinical Psychology, Volume 18 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Examining the Three-Step Theory (3ST) of Suicide in a Prospective Study of Adult Psychiatric Inpatients

Cited by 13 publications

References 50 publications

Examining suicidal desire through the lens of the three-step theory: A cross-sectional and longitudinal investigation in a community sample.

Examining suicidal desire through the lens of the three-step theory: A cross-sectional and longitudinal investigation in a community sample.

Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings

Suicide in African American Adolescents: Understanding Risk by Studying Resilience

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