Examining the link between emotional childhood abuse and social relationships in midlife: The moderating role of the oxytocin receptor gene

Ebbert, Ashley M.; Infurna, Frank J.; Luthar, Suniya S.; Lemery‐Chalfant, Kathryn; Corbin, William R.

doi:10.1016/j.chiabu.2019.104151

Cited by 21 publications

(13 citation statements)

References 131 publications

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“…According to prospective studies, maltreated children are more likely to report lower social support in adulthood ( 12 ) and unstable support across the life span ( 13 ) compared to those without a history of CM. Specific to types of CM, PA and EA are reported to be correlated with lower support in early life ( 14 ) and midlife ( 15 ) in the USA. Survivors with childhood neglect have lower social support from their families in Australia ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Childhood Emotional Neglect Is Associated With Low Social Support in Chinese Patients With Major Depressive Disorder

Qin

Wang

et al. 2021

Front. Psychiatry

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Background: Previous studies have shown that childhood maltreatment (CM) is closely associated with social support in the general population. However, little is known about the associations of different types of CM with social support in Chinese patients with major depressive disorder (MDD), which was the goal of the current study.Methods: One hundred and sixty-six patients with moderate-to-severe MDD were enrolled. Participants were assessed by the Childhood Trauma Questionnaire-28 item Short Form, Social Support Rating Scale (SSRS), the 24-item Hamilton rating scale for depression, and the 14-item Hamilton Anxiety Rating Scale. Correlation analysis and Hierarchical multiple linear regression analysis were adopted to investigate associations of types of CM with social support.Results: (1) Physical neglect (PN) and emotional neglect (EN) were the most commonly reported types of CM in patients with MDD. (2) EN was the only type of CM significant in the regression models of the SSRS total score, the score of subjective support, and the score of utilization of support.Limitations: The data of CM was collected retrospectively and recall bias may be introduced. Assessment of CM and social support were self-reported and could be influenced by the depression status.Conclusion: In Chinese patients with MDD, PN and EN are the most prevalent types of CM. EN is the only type of CM associated with low social support in regression models, calling for special attention in the assessment and intervention of EN.

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Section: Introductionmentioning

confidence: 99%

Childhood Emotional Neglect Is Associated With Low Social Support in Chinese Patients With Major Depressive Disorder

Qin

Wang

et al. 2021

Front. Psychiatry

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“…Children who experience socioenvironmental traumas—from famine to parental loss to abuse—fare worse on a wide range of health outcomes in adulthood ( 1 – 9 ). They are also disproportionately likely to find themselves in negative social environments as adults, including having dysfunctional or unsupportive relationships, or being socially isolated ( 10 – 12 ). Likewise, characteristics of adult social environments, including social support and social status, have repeatedly been linked to adult health and longevity ( 13 ).…”

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confidence: 99%

Social bonds do not mediate the relationship between early adversity and adult glucocorticoids in wild baboons

Rosenbaum

Zeng

Campos

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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In humans and other animals, harsh conditions in early life can have profound effects on adult physiology, including the stress response. This relationship may be mediated by a lack of supportive relationships in adulthood. That is, early life adversity may inhibit the formation of supportive social ties, and weak social support is itself often linked to dysregulated stress responses. Here, we use prospective, longitudinal data from wild baboons in Kenya to test the links between early adversity, adult social bonds, and adult fecal glucocorticoid hormone concentrations (a measure of hypothalamic–pituitary–adrenal [HPA] axis activation and the stress response). Using a causal inference framework, we found that experiencing one or more sources of early adversity led to a 9 to 14% increase in females’ glucocorticoid concentrations across adulthood. However, these effects were not mediated by weak social bonds: The direct effects of early adversity on adult glucocorticoid concentrations were 11 times stronger than the effects mediated by social bonds. This pattern occurred, in part, because the effect of social bonds on glucocorticoids was weak compared to the powerful effects of early adversity on glucocorticoid levels in adulthood. Hence, in female baboons, weak social bonds in adulthood are not enough to explain the effects of early adversity on glucocorticoid concentrations. Together, our results support the well-established notions that early adversity and weak social bonds both predict poor adult health. However, the magnitudes of these two effects differ considerably, and they may act independently of one another.

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“…Despite a recent trend toward the study of certain environmental conditions, mainly including stressful life events [34], specificity of childhood rearing [35,36], childhood abuse [37], peers' delinquency [18] and socioeconomic status [20] separately, which can affect molecular-genetic mechanisms underlying empathy, prosocial and aggressive behavior, the data on the other potential confounders is scarce. Moreover, the number of studies examining gene-by-environment interactions in severe types of antisocial behavior (i.e.…”

Section: Discussionmentioning

confidence: 99%

The association study of polymorphic variants of hypothalamic-pituitary-adrenal system genes (AVPR1B, OXTR) and aggressive behavior manifestation: a focus on social environment

Казанцева¹,

Davydova²,

Enikeeva³

et al. 2021

RRB

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Background: Aggressive behavior (AB) represents an important social problem, which results in significant costs for the society. A significant role in developing aggression is suggested to be mediated by molecular mechanisms related to the functioning of oxytocin (OXTR) and arginine vasopressin receptor (AVPR1B) genes involved in the regulation of social behavior. On the other hand, a specificity of environmental factors affecting an individual at various stages of development may modulate the molecular processes, especially at gene expression level, thus affecting human’s ability to self-control and resulting in AB manifestation. The aim of the study: Considering a multifactorial nature of developing aggression, the present study is aimed to estimate both the genetic- and haplotype-based effects of the OXTR and AVPR1B genes and gene-by-environment interactions in developing AB. Materials and methods: The genotyping of the OXTR (rs2228485, rs53576) and AVPR1B (rs33911258) gene variants was conducted via PCR with fluorescent detection in 189 criminal offenders (7% women) from the Republic of Bashkortostan, who committed murders, and the control group (N=254, 12% women) corresponding to the group of criminal offenders by ethnicity and age. Statistical analysis was performed via logistic regression with correction for multiple comparisons (PLINK v.1.09). Results: As a result of statistical analysis the association of rs2228485 A-allele and AG haplotype (rs2228485 and rs53576) in the OXTR gene with an enhanced risk for developing AB was observed. In addition, we demonstrated a modulating effect of such environmental factors as the presence of severe somatic diseases, alcohol addiction, fa milial history of psychopathologies, income and education level. Moreover, the effect of rs33911258 G-allele in the AVPR1B gene on AB was observed. Conclusion: The data obtained evidence that the examined variants in the AVPR1B and OXTR genes in combination with specific environmental factors may affect neuronal systems functioning, thus resulting in the manifestation of antisocial behavior.

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Examining the link between emotional childhood abuse and social relationships in midlife: The moderating role of the oxytocin receptor gene

Cited by 21 publications

References 131 publications

Childhood Emotional Neglect Is Associated With Low Social Support in Chinese Patients With Major Depressive Disorder

Childhood Emotional Neglect Is Associated With Low Social Support in Chinese Patients With Major Depressive Disorder

Social bonds do not mediate the relationship between early adversity and adult glucocorticoids in wild baboons

The association study of polymorphic variants of hypothalamic-pituitary-adrenal system genes (AVPR1B, OXTR) and aggressive behavior manifestation: a focus on social environment

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