Vacuum fluctuations are one of the most distinctive aspects of quantum optics, being the trigger of multiple nonclassical phenomena. Thus, platforms like resonant cavities and photonic crystals that enable the inhibition and manipulation of vacuum fluctuations have been key to our ability to control light-matter interactions (e.g., the decay of quantum emitters). Here, we theoretically demonstrate that vacuum fluctuations may be naturally inhibited within bodies immersed in epsilon-and-mu-near-zero (EMNZ) media, while they can also be selectively excited via bound eigenmodes. Therefore, zero-index structures are proposed as an alternative platform to manipulate the decay of quantum emitters, possibly leading to the exploration of qualitatively different dynamics. For example, a direct modulation of the vacuum Rabi frequency is obtained by deforming the EMNZ region without detuning a bound eigenmode. Ideas for the possible implementation of these concepts using synthetic implementations based on structural dispersion are also proposed.metamaterial | quantum optics | near-zero refractive index | ENZ | vacuum fluctuation V acuum fluctuations, the fluctuations of a quantized field on its vacuum state around its zero average (1), are considered one of the most distinctive (1-3) and disputed (4) aspects of quantum optics and quantum field theory. Although direct measurements of vacuum fluctuations have only been proposed very recently (5), they are the attributed source of numerous nonclassical phenomena, including, for instance, spontaneous emission (6), Lamb shift (7), Casimir forces (8), molecular energy transfer (9), quantum friction (10), as well as several vacuum amplification effects (3). It is also a well-established fact that macroscopic bodies modify the structure of electromagnetic fields, opening up the possibility of engineering all aforementioned effects (6, 11). For example, because quantum fields fluctuate in a space empty of matter, we could ask what should be the matter filling the space to first inhibit and then selectively engineer vacuum fluctuations (Fig. 1A). Traditional answers to this question have appeared in the form of photonics crystals (PCs) (12-15) and closed cavities (16-18), leading to formidable advances in the ability to control light-matter interactions. In essence, the geometry of periodic structures and resonators can be engineered in such a way so that they do not support eigenmodes on a given frequency range. Here, we demonstrate theoretically that epsilon-mu-near-zero (EMNZ) media (19), also known as matched zero-index (ZI) media (20), that is, a medium with simultaneously zero permittivity and permeability, behaves as a natural inhibitor of vacuum fluctuations. Thus, we propose ZI structures as an alternative platform to manipulate spontaneous emission, and other related effects, possibly leading to the exploration of qualitatively different decay dynamics.Note than one could conceivably approach this problem by using a canonical quantization procedure (1). In this manner, we...