“…Thirdly, the negative effect of loneliness on depression is not only accounted by its role as a powerful stressor of a social nature, as previously suggested ( Hawkley & Cacioppo, 2010 ; Heinrich & Gullone, 2006 ), but also by impairing our ability to deal with stressing adverse events, in line with recent studies ( Hofmann & Hayes, 2019 ). In other words, it seems that loneliness increases the risk of a psychologically inflexible pattern of behavior characterized by seeking to avoid, scape, or control stressful thoughts and feelings despite their harmful consequences or at the expense of more effective and meaningful actions ( Bond et al, 2011 ; Browning, Van Kirk & Krompinger, 2021 ; Levin et al, 2014 ). Moreover, consistent with this interpretation, perceived stress also increases the risk of psychological inflexibility, enhancing the risk of depression; in other words, psychological inflexibility accounted for a significant part of the impact of perceived stress on depression.…”