IntroductionDown syndrome (DS), an easily recognized congenital disease, is associated with a high prevalence of dental anomalies. Therefore, special dental care is required.Case presentationThis case report described the minimally invasive prosthetic rehabilitation of a 31‐year‐old female patient with DS. Prompt diagnosis, consultation with physicians and family, and accurate medical history were needed, and relevant dental, medical, mental, and behavioral factors were considered. A minimally invasive treatment plan was decided after clinical examination, orthopantomography (OPG), and study model analysis. For the upper jaw, an over denture was constructed. For the lower jaw, a simple metal‐frame partial denture was made. This treatment plan was decided after considering the difficulty in dentist‐patient collaboration and a small maxilla with poor positioning of teeth and negative overbite and over jet.ConclusionConsidering different patient factors including patient cooperation, as well as the medical and dental conditions associated with DS, a minimally invasive prosthodontic treatment option was recommended.