Examine Thy Heart With All Diligence

Daghini, Elena; Ritman, Erik L.; Lerman, Lilach O.

doi:10.1161/01.hyp.0000253086.74365.52

Cited by 5 publications

(3 citation statements)

References 63 publications

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“…The most commonly used techniques are Doppler echocardiography, tissue Doppler echocardiography, magnetic resonance imaging, and radionuclide angiography [22]. With high temporal resolution (50 ms/image) that minimizes motion artifacts, EBCT allows time-dependent tracking of LV volume changes throughout the cardiac cycle and the determination of peak-filling and peak-emptying rates and thereby a quantitative analysis of diastolic function [23]. Clinical studies in healthy individuals showed a good correlation between EBCT and contrast-enhanced echocardiography for the determination of end-diastolic and end-systolic ventricular volume, stroke volume, and ejection fraction [24].…”

Section: Discussionmentioning

confidence: 99%

Simvastatin preserves diastolic function in experimental hypercholesterolemia independently of its lipid lowering effect

et al. 2011

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Objective: Isolated diastolic dysfunction is present in 40% of heart failure patients. It has been attributed to myocardial fibrosis and related to cardiovascular risk factor exposure. We hypothesized that simvastatin will improve these dynamics in experimental hypercholesterolemia (HC). Methods: Three groups of pigs were studied after 12 weeks of normal (N) diet, HC diet, or HC diet with simvastatin (80 mg/day) treatment. Cardiac function was assessed by electron beam computed tomography (EBCT) and percentage of myocardium occupied by microvessels (myocardial vascular fraction) was calculated by micro-CT. Collagen content was determined by Sirius red staining and confirmed by a quantitative, hydroxyoproline-based assay. Results: Compared with N, LDL serum concentration was higher in HC and HC + simvastatin (1.0 ± 0.1 vs. 7.9 ± 1.7 and 9.6 ± 1.2 mmol/L, p < 0.05 for both). Cardiac early diastolic filling was reduced in HC compared with N (102.4 ± 11.3 vs. 151.1 ± 12.1 mL/s; p < 0.05) but restored in HC + simvastatin (176.8 ± 21.3 mL/s, p < 0.05 vs. HC). Compared with N, myocardial vascular fraction was higher in HC but not in HC + simvastatin (1.98 ± 0.84 vs. 4.48 ± 0.31 and 2.95 ± 0.95%; p < 0.05 for HC vs. N). Myocardial collagen content was higher in HC than in HC + simvastatin and N (4.72 ± 1.03 vs. 1.62 ± 0.12 and 1.21 ± 0.24% area staining; p < 0.05 for HC vs. N), which was attributable mainly to an increase in collagen III (2.90 ± 0.48 vs. 1.62 ± 0.12 and 1.21 ± 0.24% area staining; p < 0.05 for HC vs. N). Conclusions: Simvastatin is able to prevent diastolic dysfunction in experimental HC independent of its lipid lowering effect. This beneficial effect is, at least partially, due to a decrease in myocardial fibrosis and angiogenesis.

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Section: Discussionmentioning

confidence: 99%

Simvastatin preserves diastolic function in experimental hypercholesterolemia independently of its lipid lowering effect

et al. 2011

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“…Reconstruction algorithms and multirow detectors applied in current scanners enable three-dimensional volumetric imaging and multiple highquality reconstructions of various volumes of interest. 13 Current clinical scanners used for cardiovascular imaging employ either a rotating x-ray source with a circular, stationary detector array (e.g., helical CT) or electromagnetic deflection of an electron beam to replace mechanical motion (electron beam computed tomography [EBCT]).…”

Section: Computed Tomographymentioning

confidence: 99%

“…30 Diastolic function can also be assessed from the rate of change of the LV volume during diastole. 13 Also, because temporal resolution for electrocardiographic-gated cardiac CT scans (down to 165 ms) is poorer in comparison to cine CMRI (30 -40 ms), CT imaging may miss peak ejection rate or peak filling rate. However, advances in MDCT imaging that will improve temporal resolution may correct this problem.…”

Section: Cardiac Volumes and Functionmentioning

confidence: 99%