This article proposes to link the Five Factor Model (FFM) personality traits to the vocational interest circumplex, a structural model for (1) the interrelations between interest domains and (2) individual differences in interest profiles. Study 1 presents a reanalysis and meta-analytic integration of prior studies (N = 18,291, k = 27) on the relationships between FFM traits and RIASEC interests. Results indicated that all FFM traits are associated with different interest configurations and that the strength of the relationship varies between traits. Study 2 uses a latent circumplex model that partitions the shared variance among interest scales into individual differences in profile levels and profile configurations. This made it possible to estimate standardized effect sizes of the strength of the relationship that allow a more meaningful interpretation about the actual overlap between the construct domains. The latent model was applied to the aggregated correlation matrix from Study 1 and to two additional datasets from Germany (N = 1,032) and Belgium (N = 1,317) that used an alternative eight-type interest taxonomy. Results were remarkably consistent across taxonomies and samples. The associations between FFM traits and interest profiles were mainly attributable to interest configurations. Openness was nearly as strongly related to individual differences in interest configurations as a typical interest scale. Similar strong associations with interest configurations were also found for Extraversion and Agreeableness, whereas those with Neuroticism and Conscientiousness were weaker. In sum, our findings suggest that the overlap between the two construct domains is considerably stronger than previously assumed.