Examination of the Mitogenic Activity of Materials from Fungi on Murine Lymphocytes <i>In Vitro</i>

Yadomae, Toshiro; Suzuki, I.; Yonekubo, Hisao; Nunomura, Koichi; Miyazaki, Toshio

doi:10.1111/j.1348-0421.1979.tb00523.x

Cited by 7 publications

(1 citation statement)

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“…The difference in the effects on anti-SRBC and anti-TNP PFC responses may be due to the small number of precursor B cells committed to produce anti-SRBC antibodies (1), and to the greater sensitivity of SRBC coupled with TNP to action of antibodies and complement in comparison with that of normal SRBC. In the in vivo experiments, the substances from all species of fungi tested showed significant enhancing effect on day 3 (Tables 2-1, 2-2), and this enhancement correlated with their mitogenic activity reported previously (15). The findings that PBA activity was greater on day 3 than on day 5 coincides with other reports (8,9).…”

Section: Suzuki Et Alsupporting

confidence: 80%

Examination of the Polyclonal B Cell Activator and Adjuvant from Fungi

Suzuki

Yonekubo

Yadomae

et al. 1982

Microbiology and Immunology

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Section: Suzuki Et Alsupporting

confidence: 80%

Examination of the Polyclonal B Cell Activator and Adjuvant from Fungi

Suzuki

Yonekubo

Yadomae

et al. 1982

Microbiology and Immunology

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Immunological studies on the antitumor components of the basidiocarps ofAgrocybe cylindracea

et al. 1997

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The effects of cylindan, a polysaccharide isolated from the basidiocarps ofAgrocybe cylindracea, on murine sarcoma 180 tumor and murine immune cells were examined after intraperitoneal administration. Cylindan exhibited a marked life extension effect in mice against ascite forms of sarcoma 180 and Lewis lung carcinoma at a dose of 50 mg/kg/day, although it did not show any direct cytotoxicity against sarcoma 180, X5563, and MM46 murine tumor cells. Cylindan increased numbers of bone marrow stem cells as well as peritoneal exudate cells in flow cytometry using monoclonal antibodies. The tumor bearing mice group apparently showed the increase of macrophages and cytotoxic T lymphocytes in mouse spleen cells during the early stage of tumor growth. But during the later stage, the control group decreased immune cells and cylindan restored the decreased immune cells in the tumor bearing mice to the normal level. In non-specific immune response, cylindan stimulated the bacterial phagocytosis and acid phosphatase production in macrophages. It also activated components of the alternative complement pathway and natural killer activity against YAC-1 lymphoma. In humoral immunity, cylindan had a mitogenic effect against splenocytes and increased the number of plasma cells as token of stimulation of the differentiation of B lymphocytes. In cellular immunity, cylindan restored the depressed response of delayed type hypersensitivity in the tumor bearing mice to 60% of the normal level and increased the interleukin-2 (IL-2) responsiveness in the IL-2 dependent CTLL-2 cells. These results suggest that cylindan did not show direct cytotoxic effects on tumor cells but restored the decreased immune response of the tumor bearing mice.

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