Examination of Protective Effect of Ischemic Postconditioning After Small Bowel Autotransplantation

Ferencz, Andrea; Takács, Ildikó; Horváth, Szabina; Ferencz, A.; Jávor, Szaniszló; Fekecs, Tamás; Shanava, K.; Balatonyi, Borbála; Wéber, György

doi:10.1016/j.transproceed.2010.05.023

Cited by 17 publications

(12 citation statements)

References 6 publications

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“…Similar results were obtained by postconditioning with prolonged 60 min ischemia and 3 cycles of 30 sec reperfusion and reocclusion [ 18 ]. Studies using other animal models showed that LIPo before reperfusion mitigated oxidative stress and histologic damage during porcine small bowel autotransplantation [ 19 ]. However, Bretz et al showed that, after 45 min of complete vascular occlusion of the jejunum, postconditioning with 4 cycles of 30 sec reperfusion and 30 sec reocclusion during the initial 4 min of 2 h reperfusion did not decrease the effects of prolonged I/R on rabbit small intestine [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model

Dong

et al. 2016

Gastroenterology Research and Practice

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Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postconditioning (LIPo) and remote ischemia postconditioning (RIPo) on intestinal I/R injury. We concluded that LIPo affords protection in intestinal I/R injury in a comparable fashion with RIPo by decreasing oxidative stress, neutrophil activation, and apoptosis.

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Section: Discussionmentioning

confidence: 99%

Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model

Dong

et al. 2016

Gastroenterology Research and Practice

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“…Oxidative stress has been associated with the disruption of tight junctions by several mechanisms such as the elevation of oxidized membrane lipids that alter the localization of tight junction proteins and the direct alteration of claudins extracellular redox sensitive motifs [37–39, 64]. Postconditioning has been postulated to downregulate the generation and release of ROS in models of intestinal IR [20, 65]. The importance of intervening at the onset of the reperfusion is underlined by the recognition that in the first minutes of the reperfusion there is a substantial burst of oxygen-derived free radicals.…”

Section: Discussionmentioning

confidence: 99%

Impaired Intestinal Mucosal Barrier upon Ischemia-Reperfusion: “Patching Holes in the Shield with a Simple Surgical Method”

Oliver

Ónody

Kovács

et al. 2014

BioMed Research International

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Mesenteric ischemia-reperfusion (IR) is associated with impairment of the gut barrier function and the initiation of a proinflammatory cascade with life-threatening results. Therefore methods directed to ameliorate IR injury are of great importance. We aimed at describing the effects of postconditioning (PC) on the alterations of the intestinal mucosal function and the inflammatory response upon mesenteric IR. Methods. Male Wistar rats were gavaged with green fluorescent protein-expressing E. coli suspensions. Animals were randomized into three groups (n = 15), sham-operated, IR-, and PC-groups, and underwent 60 minutes of superior mesenteric artery occlusion, followed by 6 hours of reperfusion. Postconditioning was performed at the onset of reperfusion. Blood and tissue samples were taken at the end of reperfusion, for histological, bacteriological, and plasma examinations. Results. The PC-group presented a more favorable claudin-2, claudin-3, claudin-4, and zonula occludens-1 membrane expression profile, and significantly lower rates of bacterial translocation to distant organs and plasma D-lactate levels compared to the IR-group. Histopathological lesions, plasma I-FABP, IL-6, and TNF-α levels were significantly lower in the PC-group compared to the IR-group. Conclusion. The use of postconditioning improved the integrity of the intestinal mucosal barrier upon mesenteric IR, and thus reduced the incidence of bacterial translocation and development of a systemic inflammatory response.

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“…8,11,32,33 Postconditioning with controlled reperfusion has also been shown to be beneficial in preventing ischemia reperfusion injury in most of the organs such as liver, kidney, retina, and small intestine. [34][35][36][37][38][39][40] That could explain why the animals with SCPR + CP had an overall improvement in their status, survived and continued to improve to 48 h. This study has limitations. First, we did not perform a dosing study and therefore we cannot comment what is the best combination of cycles and duration of pauses.…”

Section: Discussionmentioning

confidence: 99%

Ischemic postconditioning at the initiation of cardiopulmonary resuscitation facilitates functional cardiac and cerebral recovery after prolonged untreated ventricular fibrillation

et al. 2012

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Examination of Protective Effect of Ischemic Postconditioning After Small Bowel Autotransplantation

Cited by 17 publications

References 6 publications

Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model

Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model

Impaired Intestinal Mucosal Barrier upon Ischemia-Reperfusion: “Patching Holes in the Shield with a Simple Surgical Method”

Ischemic postconditioning at the initiation of cardiopulmonary resuscitation facilitates functional cardiac and cerebral recovery after prolonged untreated ventricular fibrillation

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