Examination of Packaged Consumer Goods by Using FT-Raman Spectrometry

Compton, D. A. C.; Compton, Senja V.

doi:10.1366/0003702914335148

Cited by 14 publications

(7 citation statements)

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“…The results obtained in this work proved the potential of Raman spectroscopy for the characterization of industrial pharmaceutical products, which was already demonstrated by several authors 20–27…”

Section: Discussionsupporting

confidence: 85%

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Influence of environment on piroxicam polymorphism: Vibrational spectroscopic study

2000

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FTIR and FT‐Raman spectroscopies were used to evaluate the mechanism of transformation of piroxicam into its different forms (α, β, and monohydrate), depending on the environment. These vibrational techniques allowed us to identify the forms of piroxicam that crystallize from different solvents at different cooling rates and the conformation of the drug in some of its derivatives: piroxicam hydrochloride, piroxicam thallium and sodium salt hemihydrates, and piroxicam sodium salt. The usefulness of Raman spectroscopy in characterizing piroxicam:β‐cyclodextrin (PβCD) inclusion compounds was described. The Raman spectrum of 1:2 PβCD was discussed in comparison with that of the corresponding piroxicam sodium salt containing inclusion compound (1:2 PNaβCD) in order to study the influence of the piroxicam derivative used on the structure of the inclusion compound. The Raman results showed that in both of the inclusion compounds the piroxicam mainly assumes the zwitterionic structure typical of a monohydrate; therefore, the kind of derivative used does not affect the conformation of the drug in its inclusion compound. The effect of the method of synthesis utilized (freeze‐drying or freeze–thaw cycling) to obtain 1:2.5 PβCD was investigated. The inclusion compound obtained by freeze–thaw cycling proved to be more crystalline and to contain a higher amount of the β form than the freeze‐dried inclusion compound. Raman spectroscopy proved to be a useful technique for evaluating the effectiveness of the manufacturing process in relation to the pharmaceutical properties of the drug and to the nondestructive and noninvasive on‐line quality control of the industrial products. © 2000 John Wiley & Sons, Inc. Biopolymers (Biospectroscopy) 62: 68–78, 2001

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Section: Discussionsupporting

confidence: 85%

“…Moreover, because it is possible to obtain high‐quality spectra of the sample without removing it from the package, this technique enables nondestructive and noninvasive on‐line quality‐control checks to be performed on the final industrial products 20–22…”

Section: Discussionmentioning

confidence: 99%

Influence of environment on piroxicam polymorphism: Vibrational spectroscopic study

2000

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“…In addition, Raman spectrometers can be con gured to allow for the analysis of explosive materials in glass or plastic containers. 16 However, Lewis et al 13 noted that certain explosives (e.g., Semtex, C4, HNBP, and picric acid) exhibit uorescence even with 785-nm excitation. The impurities, rather than the sample itself, are frequently the cause of the uorescence in explosives.…”

Section: Introductionmentioning

confidence: 99%

Anti-Stokes Raman Spectrometry with 1064-nm Excitation: An Effective Instrumental Approach for Field Detection of Explosives

Lewis

Griffiths

2004

Appl Spectrosc

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Anti-Stokes Raman spectra of 28 explosive materials were obtained with 1064-nm excitation using fiber-optic sampling and a dispersive spectrograph equipped with a charge-coupled device (CCD) array detector. By using a silicon CCD detector, anti-Stokes features could clearly be observed for the majority of samples from -250 to -1650 cm(-1). Using the fiber-optic probe, spectra were routinely obtained from samples positioned up to twelve meters from the spectrograph within 240 s. The utility of an anti-Stokes correction routine is demonstrated, which routine allowed anti-Stokes spectra measured with 1064-nm excitation to be successfully searched and identified against libraries of Stokes spectra obtained using a Fourier transform (FT) Raman system equipped with a 1064-nm Nd:YAG laser.

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“…8 Nevertheless, the reported applications of Raman spectroscopy to the identi cation of form ulated and packaged drug products have been minimal. 9,10 Some efforts have already been made for the application of Raman spectroscopy to the quantitative determination of active ingredients or impurities in solid dosage form s and the purity determination of bulk pharm aceutics. 9,[11][12][13][14] The main reasons for the limited quantitative applications are the sm all content of active drug in many formulated products in com bination with the small scattering cross-sections and the uorescence interference from the active substance or the excipients.…”

Section: Introductionmentioning

confidence: 99%

“…8 As a result, FT-Raman spectroscopy has been shown to be capable for the identi cation of formulated products inside plastic blister packages with minimal or no interference from the packaging material. 10,15 The capability of quantitative analysis without rem oving tablets from their PVC blister package renders FT-R aman spectroscopy a promising technique for analysis of solid pharm aceutical dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Rapid, Noninvasive Quantitative Determination of Acyclovir in Pharmaceutical Solid Dosage Forms through Their Poly(Vinyl Chloride) Blister Package by Solid-State Fourier Transform Raman Spectroscopy

Skoulika

Georgiou

2003

Appl Spectrosc

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Fourier transform (FT) Raman spectroscopy based on band intensity or band area measurements was used for the quantitative determination of acyclovir in pharmaceutical solid dosage forms through their poly(vinyl chloride) blister package. Univariate calibration using the bands observed at 1690, 1630, 1574, 1482, 1181, 578, and 508 cm(-1) was found to be sufficient for the analysis. Calibration curves were linear, the correlation coefficients being 0.997-0.9993 and 0.996-0.9991 for band intensity and band area measurements, respectively. Results obtained compare well, as indicated by the t-test, with those obtained by the current United States Pharmacopoeia (USP 24) and National Formulary (NF 19) method. Precision ranged from 0.7-4.5 and 0.4-4.0% RSD (n = 3) for band intensity and band area measurements, respectively. The developed nondestructive FT-Raman method is rapid, simple, and can be used for the on-line, real-time monitoring of acyclovir formulation production lines.

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Examination of Packaged Consumer Goods by Using FT-Raman Spectrometry

Cited by 14 publications

References 0 publications

Influence of environment on piroxicam polymorphism: Vibrational spectroscopic study

Influence of environment on piroxicam polymorphism: Vibrational spectroscopic study

Anti-Stokes Raman Spectrometry with 1064-nm Excitation: An Effective Instrumental Approach for Field Detection of Explosives

Rapid, Noninvasive Quantitative Determination of Acyclovir in Pharmaceutical Solid Dosage Forms through Their Poly(Vinyl Chloride) Blister Package by Solid-State Fourier Transform Raman Spectroscopy

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