Examination of nanoparticles as a drug carrier on blood flow through catheterized composite stenosed artery with permeable walls

Ijaz, S.; Nadeem, S.

doi:10.1016/j.cmpb.2016.05.004

Cited by 50 publications

(37 citation statements)

References 38 publications

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“…These results were also analyzed by Ijaz and Nadeem [31]. Rahbari et al [32] and Imran et al [33] also discussed similar observations. of red blood cells, the lesser the viscosity and hence the greater the velocity of the blood with nanoparticles.…”

Section: Contemporary Mathematics Volume 3 Issue 3|2022| 281supporting

confidence: 71%

Study of Effect of Different Shapes of Nanoparticles in Three-Layer Model for Blood Flow in Arterioles

Bali

Prasad

Mishra

2022

Contemporary Mathematics

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Arterioles are pivotal console of hemodynamics as they are significant contributors to pressure. Under various physiological conditions like administration of a drug, arterioles ascertain divergent mechanical forces. The current communication discusses the effect of different shapes of copper nanoparticles inoculated as nano drugs in arterioles. The blood is assumed to be a non-Newtonian fluid and is delineated as nanofluids. The three-layer model is used for modeling the blood flow as it aptly describes the flow of blood in narrow vessels of diameter less than 100 μm. The Hamilton-Crosser model is implemented to describe the thermal conductivity of nanofluid as this model holds in accordance with experimental as well as theoretical results. The expressions are also obtained for density, thermal expansion and viscosity of the considered nanofluid. The equations are solved analytically and graphs have been plotted using MATLAB. The relative consequence of various shapes of nanoparticles like platelets, blades, cylinders and bricks is observed in temperature, velocity and flow rate. It has been investigated through the graphs that brick-shaped nanoparticles have shown a maximum rise in temperature, velocity and flow rate. And reverse results are observed for blade-shaped nanoparticles. The effect of volume fraction, heat source parameter and Grashof number have also been inspected. The considered analysis shows that a suitable shape of nanoparticle can be used to develop the nano drug according to biomedical needs.

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Section: Contemporary Mathematics Volume 3 Issue 3|2022| 281supporting

confidence: 71%

Study of Effect of Different Shapes of Nanoparticles in Three-Layer Model for Blood Flow in Arterioles

Bali

Prasad

Mishra

2022

Contemporary Mathematics

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“…One example of this technology is developing nanoparticles to help carry chemotherapy drugs directly to malignant growths and provide pharmaceuticals to damaged regions of arteries to address cardiovascular disease. Ijaz et al [1] addressed how Cu-nanoparticles affect the blood flow through a porous artery with composite stenosis. Using an appropriate mathematical model, Nadeem et al [2] examined the impact of nanoparticles on blood flow properties through an artery with bell-shaped stenosis.…”

Section: Radial Direction (M)mentioning

confidence: 99%

Modeling and analysis of magnetic hybrid nanoparticle (Au-Al2O3/blood) based drug delivery through a bell-shaped occluded artery with joule heating, viscous dissipation and variable viscosity effects

Gandhi

Sharma

Kumawat

et al. 2022

Proceedings of the Institution of Mechanical Engineers, Part E:

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The present work deals with the impact of hybrid nanoparticles (Au-Al2O3) on the blood flow pattern through a porous cylindrical artery with a bell-shaped stenosis in the presence of an external magnetic field, Joule heating, and viscous dissipation by considering two-dimensional pulsatile blood flow. The temperature-dependent viscosity model is utilized in this study. The blood flow is assumed to be unsteady, laminar, viscous, and incompressible. The mild stenotic presumption normalizes and reduces the bi-directional flow to uni-directional. The Crank-Nicolson scheme is applied to solve the continuity, momentum, and energy equations with appropriate initial and boundary conditions. Transport characteristics are visualized graphically for key dimensionless parameters such as Magnetic number ([Formula: see text]), Darcy number ( Da), Grashof number ( Gr), viscosity parameter ( β0), Reynolds number ( Re), Eckert Number ( Ec), Prandtl number ( Pr), different concentration of both the nanoparticles ( ϕ1, ϕ2), and pressure gradient parameter ( B1). The velocity contours for different emerging parameters have also been drawn to assess the overall behaviour of blood flow patterns. The non-dimensional velocity profile is enhanced with increment in values of Da, implying that the medium permeability provides less resistance to the flow. Increasing viscous dissipation ( Ec) and Joule heating ([Formula: see text]) parameter simultaneously raise the nanofluid temperature. Hybrid nanoparticles (Au-Al2O3/blood) effectively reduce hemodynamic variables such as wall shear stress and resistance (impedance). The present work finds applications in nano-mediated treatment of atherosclerosis and other diseases.

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“…Here, the subscript (1) corresponds to first nanoparticle (CuO), while subscript (2) is applied for second nanoparticle (Cu) as well as subscript (f) is related to primary base fluid (pure blood). Table I demonstrates thermophysical properties of the primary base fluid and nanoparticles (Ijaz and Nadeem, 2016;Vajjha et al, 2010;Turkyilmazoglu, 2014;Mott et al, 2007).…”

Section: Hff 2911mentioning

confidence: 99%

Improvement of drug delivery micro-circulatory system with a novel pattern of CuO-Cu/blood hybrid nanofluid flow towards a porous stretching sheet

Dinarvand

Rostami

Dinarvand

et al. 2019

HFF

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Purpose This paper aims to simulate the steady laminar mixed convection incompressible viscous and electrically conducting hybrid nanofluid (CuO-Cu/blood) flow near the plane stagnation-point over a horizontal porous stretching sheet along with an external magnetic field and induced magnetic field effects that can be applicable in the biomedical fields like the flow dynamics of the micro-circulatory system and especially in drug delivery. Design/methodology/approach The basic partial differential equations (PDEs) are altered to a set of dimensionless ordinary differential equations (ODEs) with the help of suitable similarity variables which are then solved numerically using bvp4c scheme from MATLAB. Inasmuch as validation results have shown a good agreement with previous reports, the present novel mass-based algorithm can be used in this problem with great confidence. Governing parameters are both nanoparticle masses, base fluid mass, empirical shape factor of both nanoparticles, suction/injection parameter, magnetic parameter, reciprocal magnetic Prandtl number, Prandtl number, heat source parameter, mixed convection parameter, permeability parameter and frequency ratio. The effect of these parameters on the flow and heat transfer characteristics of the problem is discussed in detail. Findings It is shown that the use of CuO and Cu hybrid nanoparticles can reduce the hemodynamics effect of the capillary relative to pure blood case. Moreover, as the imposed magnetic field enhances, the velocity of the blood decreases. Besides, when the blade shapes for both nanoparticles are taken into account, the local heat transfer rate is maximum that is also compatible with experimental observations. Originality/value An innovative mass-based model of CuO-Cu/blood hybrid nanofluid has been applied. The novel attitude to one-phase hybrid nanofluid model corresponds to considering nanoparticles mass as well as base fluid mass to computing the solid equivalent volume fraction, the solid equivalent density and also solid equivalent specific heat.

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Examination of nanoparticles as a drug carrier on blood flow through catheterized composite stenosed artery with permeable walls

Cited by 50 publications

References 38 publications

Study of Effect of Different Shapes of Nanoparticles in Three-Layer Model for Blood Flow in Arterioles

Study of Effect of Different Shapes of Nanoparticles in Three-Layer Model for Blood Flow in Arterioles

Modeling and analysis of magnetic hybrid nanoparticle (Au-Al2O3/blood) based drug delivery through a bell-shaped occluded artery with joule heating, viscous dissipation and variable viscosity effects

Improvement of drug delivery micro-circulatory system with a novel pattern of CuO-Cu/blood hybrid nanofluid flow towards a porous stretching sheet

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