Examination of joint space by magnetic resonance imaging in anatomically normal knees

Sargon, Mustafa F.; Taner, Doğan; Altintaş, Kayhan

doi:10.1002/(sici)1098-2353(1996)9:6<386::aid-ca5>3.0.co;2-9

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…In both of these studies, males were generally found to have larger JSWs compared to females, results which are also consistent with those reported here [ 31 , 34 ]. In contrast, studies conducted by Dacre et al and Sargon et al showed that JSW decreased with increasing age group, although both of these studies were cross sectional in nature and methodological differences existed including X-ray acquisition technique (weight bearing vs. non-weight bearing), joint space analysis (manual vs. automated, joint space area (mm 2 ) vs. mJSW [ 33 ]) and the symptomatic nature of patients [ 32 , 33 ]. While our results and those of other cross-sectional studies of healthy individuals suggest mJSW values remain constant, other results suggesting the opposite justify the need for large-scale, cross-sectional and longitudinal population-based data of healthy individuals acquired using the most reproducible techniques [ 22 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: A cross-sectional study

Beattie

Duryea

Pui

et al. 2008

BMC Musculoskelet Disord

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Background: The clinical use of minimum joint space width (mJSW) and cartilage volume and thickness has been limited to the longitudinal measurement of disease progression (i.e. change over time) rather than the diagnosis of OA in which values are compared to a standard. This is primarily due to lack of establishment of normative values of joint space width and cartilage morphometry as has been done with bone density values in diagnosing osteoporosis. Thus, the purpose of this pilot study is to estimate reference values of medial joint space width and cartilage morphometry in healthy individuals of all ages using standard radiography and peripheral magnetic resonance imaging.

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Section: Discussionmentioning

confidence: 99%

Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: A cross-sectional study

Beattie

Duryea

Pui

et al. 2008

BMC Musculoskelet Disord

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“…Karvonen et al reported that cartilage thickness decreased significantly at the femoral condylar, but not at tibial and patellar sites, 31 whereas Sargon et al reported that knee joint space declined linearly with increasing age. 22 In an early study, Eckstein et al suggested that knee cartilage volume and mean cartilage thickness were not associated with age, while patellar maximal cartilage thickness was inversely associated with age. 21 A subsequent larger study from Eckstein's group reported a substantial decrease in thickness of cartilage in the knee at all sites, although this did not reach statistical significance at the tibia.…”

Section: Discussionmentioning

confidence: 99%

“…[16][17][18][19] However, the results from early MRI studies on the association between age and knee cartilage volume and thickness are contradictory, possibly owing to the small sample size in these studies. [20][21][22][23] The largest of these studies 23 reported a substantial decrease in thickness of cartilage in the knee at all sites, although this did not reach statistical significance at the tibia. Furthermore, there is little information on the association between age, knee cartilage defects, and knee bone size (which can be measured as tibial cross sectional area and patella bone volume).…”

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confidence: 97%

Association between age and knee structural change: a cross sectional MRI based study

Ding

Cicuttini

Scott

et al. 2005

Annals of the Rheumatic Diseases

104

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Objective: To describe the associations between age, knee cartilage morphology, and bone size in adults. Methods: A cross sectional convenience sample of 372 male and female subjects (mean age 45 years, range 26-61) was studied. Knee measures included a cartilage defect five site score (0-4 respectively) and prevalence (defect score of >2 at any site), cartilage volume and thickness, and bone surface area and/or volume. These were determined at the patellar, medial, and lateral tibial and femoral sites using T 1 weighted fat saturation MRI. Height, weight, and radiographic osteoarthritis (ROA) were measured by standard protocols. Results: In multivariate analysis, age was significantly associated with knee cartilage defect scores (b = +0.016 to +0.073/year, all p,0.01) and prevalence (OR = 1.05-1.10/year, all p,0.05) in all compartments. Additionally, age was negatively associated with knee cartilage thickness at all sites (b = 20.013 to 20.035 mm/year, all p,0.05), and with patellar (b = 211.5 ml/year, p,0.01) but not tibial cartilage volume. Lastly, age was significantly positively associated with medial and lateral tibial surface bone area (b = +3.0 to +4.7 mm 2 /year, all p,0.05) and patellar bone volume (b = +34.4 ml/ year, p,0.05). Associations between age and tibiofemoral cartilage defect score, cartilage thickness, and bone size decreased in magnitude after adjustment for ROA, suggesting these changes are directly relevant to OA. Conclusion: The most consistent knee structural changes with increasing age are increase in cartilage defect severity and prevalence, cartilage thinning, and increase in bone size with inconsistent change in cartilage volume. Longitudinal studies are needed to determine which of these changes are primary and confirm their relevance to knee OA.

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“…In contrast, magnetic resonance imaging (MRI) can visualize joint structure directly and is recognized as a valid, accurate, and reproducible tool to measure articular cartilage defects (10 -14), volume, thickness, and subchondral bone size (15)(16)(17)(18)(19)(20). However, the results from early MRI studies on the association between knee cartilage and BMI are contradictory because they are generally from small samples (19,21,22). Cartilage defects (G. Jones, unpublished data) and bone size (23) may also be important in the pathogenesis of knee OA, but there is little information on the associations among BMI, knee cartilage defects, and knee subchondral bone size.…”

Section: Introductionmentioning

confidence: 99%

Knee Structural Alteration and BMI: A Cross‐sectional Study

et al. 2005

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DING, CHANGHAI, FLAVIA CICUTTINI, FIONA SCOTT, HELEN COOLEY, AND GRAEME JONES. Knee structural alteration and BMI: a cross-sectional study. Obes Res. 2005;13:350 -361. Objective: To describe the associations among BMI, knee cartilage morphology, and bone size in adults. Research Methods and Procedures:A cross-sectional convenience sample of 372 male and female subjects (mean age, 45 years; range, 26 to 61 years) was studied. Knee articular cartilage defect score (0 to 4) and prevalence (defect score of Ն2), volume, and thickness, as well as bone surface area and/or volume, were determined at the patellar, tibial, and femoral sites using T1-weighted fat-saturation magnetic resonance imaging. Height, weight, BMI, and radiographic osteoarthritis were measured by standard protocols. Results:In multivariate analysis in the whole group, BMI was significantly associated with knee cartilage defect scores (␤: ϩ0.016/kg/m 2 to ϩ0.083/kg/m 2 , all p Ͻ 0.05) and prevalence (odds ratio: 1.05 to 1.12/kg/m 2 , all p Ͻ 0.05 except for the lateral tibiofemoral compartment). In addition, BMI was negatively associated with patellar cartilage thickness only (␤ ϭ Ϫ0.021 mm/kg/m 2 ; p ϭ 0.039) and was positively associated with tibial bone area (medial: ␤ ϭ ϩ7.1 mm 2 /kg/m 2 , p ϭ 0.001; lateral: ␤ ϭ ϩ3.2 mm 2 /kg/ m 2 , p ϭ 0.037). Those who were obese also had higher knee cartilage defect severity and prevalence and larger medial tibial bone area but no significant change in cartilage volume or thickness compared with those of normal weight.Discussion: This study suggests that knee cartilage defects and tibial bone enlargement are the main structural changes associated with increasing BMI particularly in women. Preventing these changes may prevent knee osteoarthritis in overweight and obese subjects.

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Examination of joint space by magnetic resonance imaging in anatomically normal knees

Cited by 10 publications

References 19 publications

Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: A cross-sectional study

Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: A cross-sectional study

Association between age and knee structural change: a cross sectional MRI based study

Knee Structural Alteration and BMI: A Cross‐sectional Study

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