Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: A cross-sectional study

Beattie, Karen A.; Duryea, J.; Pui, Margaret H.; O’Neill, John D.; Boulos, Pauline; Webber, Colin E.; Eckstein, F.; Adachi, Jonathan D.

doi:10.1186/1471-2474-9-119

Cited by 50 publications

(40 citation statements)

References 50 publications

(61 reference statements)

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“…While we only used 18 informative locations, our CDI detected a similar trend with 35% and 64% less medial tibiofemoral CDI among knees with JSN = 2 and 3 (Table 2) compared with knees without JSN. Furthermore, prior studies have found similar correlations to ours for medial JSW and medial tibiofemoral cartilage morphology (r = 0.46 to 0.71) [27,36,37] and changes in these measures (r = 0.21 to 0.48) [24,25]. Overall, we consistently found relationships between the CDI and the severity of radiographic OA except that knees with KL grade 2 had a greater baseline CDI and less apparent progression compared with those with KL grade 1 (i.e., suggesting less damage; Table 4).…”

Section: Discussionsupporting

confidence: 86%

Development of a rapid knee cartilage damage quantification method using magnetic resonance images

Zhang

Driban

Price

et al. 2014

BMC Musculoskelet Disord

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BackgroundCartilage morphometry based on magnetic resonance images (MRIs) is an emerging outcome measure for clinical trials among patients with knee osteoarthritis (KOA). However, current methods for cartilage morphometry take many hours per knee and require extensive training on the use of the associated software. In this study we tested the feasibility, reliability, and construct validity of a novel osteoarthritis cartilage damage quantification method (Cartilage Damage Index [CDI]) that utilizes informative locations on knee MRIs.MethodsWe selected 102 knee MRIs from the Osteoarthritis Initiative that represented a range of KOA structural severity (Kellgren Lawrence [KL] Grade 0 – 4). We tested the intra- and inter-tester reliability of the CDI and compared the CDI scores against different measures of severity (radiographic joint space narrowing [JSN] grade, KL score, joint space width [JSW]) and static knee alignment, both cross-sectionally and longitudinally.ResultsDetermination of the CDI took on average14.4 minutes (s.d. 2.1) per knee pair (baseline and follow-up of one knee). Repeatability was good (intra- and inter-tester reliability: intraclass correlation coefficient >0.86). The mean CDI scores related to all four measures of osteoarthritis severity (JSN grade, KL score, JSW, and knee alignment; all p values < 0.05). Baseline JSN grade and knee alignment also predicted subsequent 24-month longitudinal change in the CDI (p trends <0.05). During 24 months, knees with worsening in JSN or KL grade (i.e. progressors) had greater change in CDI score.ConclusionsThe CDI is a novel knee cartilage quantification method that is rapid, reliable, and has construct validity for assessment of medial tibiofemoral osteoarthritis structural severity and its progression. It has the potential to addresses the barriers inherent to studies requiring assessment of cartilage damage on large numbers of knees, and as a biomarker for knee osteoarthritis progression.

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Section: Discussionsupporting

confidence: 86%

Development of a rapid knee cartilage damage quantification method using magnetic resonance images

Zhang

Driban

Price

et al. 2014

BMC Musculoskelet Disord

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“…These findings were similar to what Beattie KA et al reported for healthy individuals between the age of 50 to 70 years, with K-L grade 0, where the average JSW on the lateral compartment was 5.05mm. [29] Only three studies to date have compared the HHGS and OARSI in human knee samples. Two of these had a patient cohort of <20 patients.…”

Section: Discussionmentioning

confidence: 99%

Histopathological assessment of primary osteoarthritic knees in large patient cohort reveal the possibility of several potential patterns of osteoarthritis initiation

Mantripragada

Piuzzi

Zachos

et al. 2017

Current Research in Translational Medicine

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Objective The two main objectives of the study include 1) Test the hypothesis that the lateral femoral condyle (LFC) in patients with primary OA and varus knees undergoing total knee arthroplasty (TKA) can be used as a model to better characterize varying histological features of human OA. 2) Correlate characteristic OA features using the established histopathological scoring systems (HHGS and OARSI) to understand potential histopathological patterns of OA initiation. Design Two osteochondral specimens (4×4×8mm) were collected from fifty patient’s LFC at the time of TKA (total 100 specimens), who presented preserved lateral knee compartment with joint space width >2mm. Three independent readers graded the sections on three different occasions using HHGS and OARSI systems. The correlation between individual parameters of the two scoring systems and their inter- and intra-reader variability, reliability and reproducibility were estimated. Results All samples in this cohort showed abnormal histopathological features. Total histopathological scores of the LFC ranged from HHGS median=4.6 (range=0 to 11), and OARSI median=5.2 (range=0 to 19.5). The four individual sub-items of HHGS scoring system (structure, cells, safraninO staining, tidemark) were weakly correlated, with the correlation between structure and cellularity being the strongest (r=0.40). Both the scoring systems had similar repeatability and reproducibility coefficients of <21%. Conclusions OA changes in the LFC are not confined to any one region, and maybe seen in different regions of cartilage, tidemark, subchondral bone, and/or the marrow space vascularity. These variations may point to the possibility of several potential patterns of initiation in OA.

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“…A number of studies have explored the relation between radiographic JSN and cartilage loss on MRI, but have done so specifically in the medial compartment of the knee. Beattie et al found that in the medial compartment in individuals without knee ROA, a substantial amount of the variation in minimum JSW can be explained by variation in cartilage thickness of the medial tibia [32]. Knees with medial JSN were found cross-sectionally to have smaller medial and lateral cartilage volume, although the association may have been confounded in part by sex [33].…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease – data from the Osteoarthritis Initiative

Niu

Guermazi

Liu

et al. 2017

Osteoarthritis and Cartilage

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Objective-Isolated lateral compartment tibiofemoral radiographic osteoarthritis (IL-ROA) is an understudied form of knee osteoarthritis. The objective of the present study was to characterize MRI abnormalities and MR-T2 relaxation time measurements associated with IL-ROA and with isolated medial compartment ROA (IM-ROA) compared with knees without OA.Method-200 case subjects with IL-ROA (Kellgren/Lawrence (K/L) grade≥2 and joint space narrowing (JSN)>0 in the lateral compartment but JSN=0 in the medial compartment) were randomly selected from the Osteoarthritis Initiative baseline visit. 200 cases with IM-ROA and 200 controls were frequency matched to the IL-ROA cases. Cases and controls were analyzed for odds of having a subregion with >10% cartilage area affected, with ≥25% bone marrow lesions (BML), with meniscal tear or maceration, and for association with cartilage T2 values.Results-IL-ROA was more strongly associated with ipsilateral MRI knee pathologies than IM-ROA (IL-ROA: OR=135.2 for size of cartilage lesion, 95%CI 42.7-427.4; OR= 145.4 for large size bone marrow lesions (BML), 95%CI 41.5-509.5; OR =176 for meniscal tears, 95%CI 59.8-517.7; IM-ROA: OR=28.4 for size of cartilage lesion, 95%CI 14.7-54.7; OR= 38.1 for size of BML, 95%CI 12.7-114; OR =37.0 for meniscal tears, 95%CI 12-113.6). Cartilage T2 values were higher in both tibial and medial femoral compartments in IL-ROA, but in IM-ROA were only significantly different from controls in the medial femur.Conclusion-IL-ROA knees show a greater prevalence and severity of MRI lesions and higher cartilage T2 values than IM-ROA knees compared with controls.

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Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: A cross-sectional study

Cited by 50 publications

References 50 publications

Development of a rapid knee cartilage damage quantification method using magnetic resonance images

Development of a rapid knee cartilage damage quantification method using magnetic resonance images

Histopathological assessment of primary osteoarthritic knees in large patient cohort reveal the possibility of several potential patterns of osteoarthritis initiation

Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease – data from the Osteoarthritis Initiative

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