Examination of Claudin-1 Expression in Patients Undergoing Liver Transplantation Owing to Hepatitis C Virus Cirrhosis

Zádori, Gergely; Gelley, Fanni; Törzsök, Péter; Sárváry, Enikő; Doros, Attila; Deák, Ákos P.; Nagy, Péter; Schaff, Zsuzsa; Kiss, András; Nemes, Balázs

doi:10.1016/j.transproceed.2011.03.066

Cited by 9 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hepatocellular expression of claudin-1 was found to be increased in HCVinfected livers [66,67]. Attenuated expression of claudin-1 closely correlates with the dedifferentiation and portal invasion of hepatocellular carcinoma [35].…”

Section: Discussionmentioning

confidence: 95%

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

Erdélyi-Belle

Török

Apáti

et al. 2015

Pathol. Oncol. Res.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 95%

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

Erdélyi-Belle

Török

Apáti

et al. 2015

Pathol. Oncol. Res.

View full text Add to dashboard Cite

show abstract

“…The authors confirm the results of previous reports showing increased claudin-1 expression in HCV-infected liver. 2 , 3 However, Mensa et al conclude that claudin-1 is solely located at the apical pole of hepatocytes, in contrast to reports by Reynolds et al and Zadori et al 2 , 3 We agree that claudin-1 is predominantly expressed at the apical membrane of hepatocytes in normal liver; however, a minor pool of claudin-1 is observed at the basolateral membrane ( Fig. 1 ).…”

Section: To the Editormentioning

confidence: 45%

Heterogeneous claudin-1 expression in human liver

et al. 2013

View full text Add to dashboard Cite

“…Several cellular factors are known to be involved in the hepatocellular entry mechanism of HCV . Tight‐junction (TJ) proteins claudin‐1 (CLDN1) and occludin (OCLN), CD81, scavenger receptor class B type 1 (SCARB1) have been reported to be part of the internalization complex and are essential for HCV entry both in vitro and in vivo …”

Section: Introductionmentioning

confidence: 99%

“…4 Tight-junction (TJ) proteins claudin-1 (CLDN1) and occludin (OCLN), CD81, scavenger receptor class B type 1 (SCARB1) have been reported to be part of the internalization complex and are essential for HCV entry both in vitro and in vivo. 2,[5][6][7] Previous studies have shown discrepancies between messenger RNA (mRNA) and protein expression levels of these receptors in HCV infected patients, suggesting therefore the role of microRNAs (miRs) in the modulation of gene expression. 2,4,5 MiRs are small endogenous non-coding ∼22 nucleotide long RNAs that regulate gene expression at posttranscriptional level.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA profile before and after antiviral therapy in liver transplant recipients for hepatitis C virus cirrhosis

Gelley

Zádori

Nemes

et al. 2013

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and Aim: Management of hepatitis C virus (HCV) recurrence is a major challenge after liver transplantation. Significant dysregulated expression of HCV receptors (i.e. claudin-1, occludin, tetraspanin CD81, scavenger receptor type B1) has been shown recently during HCV infection. This might facilitate hepatocytic entry and reinfection of HCV. MicroRNAs (miRs) play role in the regulation of gene expression. We aimed to characterize miR expression profiles related to HCV infection and antiviral therapy in adult liver transplant recipients, with special emphasis on miRs predicted to target HCV receptors. Methods: Twenty-eight adult liver transplant recipients were enrolled in the study. Paired biopsies were obtained at the time of HCV recurrence and at the end of antiviral treatment. MiRs for HCV receptors were selected using target prediction software. Expression levels of miR-21, miR-23a miR-34a, miR-96, miR-99a*, miR-122, miR-125b, miR-181a-2*, miR-194, miR-195, miR-217, miR-221, and miR-224 were determined by reverse transcription-quantitative polymerase chain reaction. Results: miR-99a* and miR-224 expressions were increased in HCV recurrence samples, while miR-21 and miR-194 were decreased in comparison to normal liver tissue. Increased expressions of miR-221, miR-224, and miR-217 were observed in samples taken after antiviral therapy when compared with HCV recurrence samples. High HCV titer at recurrence was associated with higher level of miR-122. Conclusions: Samples at recurrence of HCV and after antiviral therapy revealed distinct HCV-related miR expression profiles, with significant dysregulation of those miRNAs potentially targeting mRNAs of HCV receptors. In particular, miR-194 and miR-21 might be involved in the regulation of HCV receptor proteins' expression during HCV infection and antiviral therapy.

show abstract

Examination of Claudin-1 Expression in Patients Undergoing Liver Transplantation Owing to Hepatitis C Virus Cirrhosis

Cited by 9 publications

References 21 publications

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

Heterogeneous claudin-1 expression in human liver

MicroRNA profile before and after antiviral therapy in liver transplant recipients for hepatitis C virus cirrhosis

Contact Info

Product

Resources

About