Exacerbation of Hyperparathyroidism, Secondary to a Reduction in Kidney Function, in Individuals With Vitamin D Deficiency

Daimon, Makoto; Fujita, Tomoyuki; Murabayashi, Masaya; Mizushiri, Satoru; Murakami, Hiroshi; Nishiya, Yuki; Tanabe, Jutaro; Matsuhashi, Yuki; Yanagimachi, Miyuki; Tokuda, Itoyo; Sawada, Kaori; Ihara, Kazushige

doi:10.3389/fmed.2020.00221

Cited by 5 publications

(4 citation statements)

References 43 publications

(45 reference statements)

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“…According to a systematic review and meta-analysis of twenty-two studies related to vitamin D supplementation in CKD, there was a significant decline in PTH levels with vitamin D supplementation [20]. Additionally, the analysis of eGFR and serum PTH concentration in nine hundred and thirty people from the general Japanese population revealed that eGFR < 60 ml/min/1.73m 2 is a significant risk factor for an increase in PTH levels, albeit the relationship was present only in participants with vitamin D deficiency [21].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D level in children with chronic kidney disease on conservative treatment – a pilot study

Oleksik¹,

Mieleszko²,

Prącik³

et al. 2020

polp

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Introduction: Chronic kidney disease (CKD) is characterized by alteration of mineral metabolism of calcium and phosphorus related to phosphate retention, secondary hyperparathyroidism and impairment of vitamin D hydroxylation in the kidneys. Additionally, bone disorders can be augmented by vitamin D deficiency in the diet. Study aimed at investigation of 25-hydroxyvitamin D [25(OH)D] serum level in children with CKD treated in Pediatric Nephrology Ward, its relationship with blood pressure values, selected laboratory parameters values and evaluation of seasonal and sex related differences. Material and methods: The study group included 28 children with CKD in stage 2-5 (10 girls and 18 boys; mean age 9.5 ±5.3 years), all of them were treated conservatively. The main cause of CKD in examined children were congenital abnormalities of the kidney and urinary tract (CAKUT). Mean estimated GFR was 40.3 ±23.1 ml/min/1.73 m 2. Seventy-five percent of patients were supplemented with vitamin D formulas. The evaluation of serum vitamin D was conducted during the routine visit in Paediatric Nephrology Ward. Serum level of 25(OH)D was measured by using an electrochemiluminescence method. Results: In the examined group, mean height was 126 ±29 cm, and 29% of children were under 3 rd percentile for height. The mean haemoglobin level was 12.4 ±1.9 g/dl; mean creatinine level 181.2 ±133.6 µmol/l, phosphate level 1.5 ±0.2 mmol/l; total calcium level 2.4 ±0.1 mmol/l, mean PTH level 84.5 ±62.3 pg/ml. Mean 25(OH)D serum level in CKD group was 38.3 ±14.9 ng/ml and was significantly higher than in control group (23.3 ±11.3 ng/ml; p < 0.0001). Conclusions: According to current standards of serum vitamin D level in children in Poland 61% of patients with CKD from study group had optimal vitamin D serum level without seasonal and sex related differences.

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Section: Discussionmentioning

confidence: 99%

Vitamin D level in children with chronic kidney disease on conservative treatment – a pilot study

Oleksik¹,

Mieleszko²,

Prącik³

et al. 2020

polp

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show abstract

“…This study involved patients with stage 3 to 5 CKD. A Japanese study showed that a reduction in the eGFR to < 60 mL/min/1.73 m 2 with deficient vitamin D is a significant risk factor for an increased serum PTH concentration 22 . To highlight a more typical effect, we selected more representative sample data.…”

Section: Discussionmentioning

confidence: 99%

Misdiagnosis of chronic kidney disease and parathyroid hormone testing during the past 16 years

Liu,

Zhao,

Zheng

et al. 2023

Sci Rep

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Chronic kidney disease (CKD) is a prevalent pathological condition worldwide. Parathyroid hormone (PTH) is an important index related to bone metabolism in CKD patients and has not received enough attention. This study was performed to investigate the incidence and diagnostic rate of CKDin hospital as well as PTH testing and treatment for secondary hyperparathyroidism (SHPT) in patients with stage 3 to 5 CKD. The data of patients who visited Zhejiang Provincial People's Hospital from February 2006 to April 2022 were retrieved from the hospital database. All data were divided into three subgroups using PTH testing and SHPT treatment as major comparative indicators for analysis. The data were then analyzed for overall PTH testing, CKD incidence, and diagnostic rate. Among 5,301,391 patients, the incidence of CKD was 13.14%. The missed diagnosis rate for CKD was 65.76%. The total PTH testing rate was 1.22%, of which 15.37% of PTH testing was performed in patients with stage 3 to 5 CKD. The overall diagnosis rate of SHPT in patients with stage 3 to 5 CKD was 31.0%. The prophylactic medication rate was 7.4%, and the rate of post-diagnostic drug therapy was 22.2% in patients who underwent SHPT treatment. The high misdiagnosis rate and low PTH testing rate of CKD requires prompt attention from clinicians. SHPT treatment should be considered especially in patients with stage 3 to 5 CKD.

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“…Chronic Kidney Disease (CKD) is a world health problem [1]. Global estimates of CKD indicate its prevalence in 14,3% of the general population and 36,1% of risk groups.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D concentrations and their relationship with iron parameters in patients with chronic kidney disease

Viana

Freitas

2022

Rev. Nutr.

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Objective To investigate the relationship between calcidiol (25(OH)D3) concentrations and iron parameters in patients with chronic kidney disease. Methods This is a cross-sectional, descriptive, and quantitative study. The sample consisted of 86 adult patients of both sexes undergoing dialysis. 25(OH)D3 concentrations were determined by chemiluminescence; food consumption was assessed using 24-hour recalls, and the serum levels of hemoglobin, iron, ferritin, and transferrin saturation were assessed. Data analysis was performed using the program Stata, with a significance level of p<0.05. Results The results pointed to 25(OH)D3 concentrations compatible with sufficiency, iron levels consistent with normality, and ferritin and transferrin saturation above the reference values. The consumption of carbohydrates and lipids was higher in females. There was no relationship between the adequacy of 25(OH)D3 and the presence of anemia and iron parameters. Conclusion Considering that the mean serum levels of iron and 25(OH)D3 were adequate, it is suggested that resistance to erythropoietin and the inflammatory process may have contributed to the percentage of anemic individuals found in the study.

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Exacerbation of Hyperparathyroidism, Secondary to a Reduction in Kidney Function, in Individuals With Vitamin D Deficiency

Cited by 5 publications

References 43 publications

Vitamin D level in children with chronic kidney disease on conservative treatment – a pilot study

Vitamin D level in children with chronic kidney disease on conservative treatment – a pilot study

Misdiagnosis of chronic kidney disease and parathyroid hormone testing during the past 16 years

Vitamin D concentrations and their relationship with iron parameters in patients with chronic kidney disease

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