Exacerbation of glomerulonephritis in subjects with chronic hepatitis C virus infection after interferon therapy

Ohta, Satoshi; Yokoyama, Hitoshi; Wada, Takashi; Sakai, Norihiko; Shimizu, Miho; Kato, Tamayo; Furuichi, Kengo; Segawa, Chikako; Hisada, Yukimasa; Kobayashi, Kenichi

doi:10.1016/s0272-6386(99)70140-x

Cited by 73 publications

(21 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, case series have been published [31]. Additional papers provided evidence of exacerbation of pre-existing glomerular disease during IFN [32,33]. The usual presentation of glomerular disease associated with IFN is isolated proteinuria, and nephrotic syndrome [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31].…”

Section: Discussionmentioning

confidence: 99%

Acute Tubular Necrosis Following Interferon-Based Therapy for Hepatitis C: Case Study with Literature Review

Fabrizi

Aghemo

Fogazzi

et al. 2013

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: Interferon treatment of malignant or viral diseases can be accompanied by various side-effects including nephro-toxicity. Methods: We report on a 68-year-old Caucasian male who received dual therapy with pegylated interferon 2a plus ribavirin for chronic hepatitis C. Results: After three months of antiviral therapy, the patient developed acute kidney failure (serum creatinine up to 6 mg/dL) with mild proteinuria (500 mg daily) and haematuria. Immediate immunosuppressive therapy with high-dose intravenous steroids did not improve kidney function. Kidney biopsy was consistent with acute tubular necrosis without glomerular abnormalities. He started long-term peritoneal dialysis (four regular exchanges) to provide both dialysis adequacy and ascites removal. Kidney function gradually improved over the following months (serum creatinine around 2 mg/dL) and peritoneal dialysis was continued with two exchanges daily. The temporal relationship between the administration of the drug and the occurrence of nephro-toxicity, and the absence of other obvious reasons for acute tubular necrosis support a causative role for pegylated interferon; benefit on kidney disease was noted after withdrawal of antiviral agents. An extensive review of the literature on acute tubular necrosis associated with interferon-based therapy, based on in vitro data and earlier case-reports, has been made. The proposed pathogenic mechanisms are reviewed. Conclusions: Our case emphasizes the importance of monitoring renal function during treatment of chronic hepatitis C with antiviral combination therapy as treatment may precipitate kidney damage at tubular level.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute Tubular Necrosis Following Interferon-Based Therapy for Hepatitis C: Case Study with Literature Review

Fabrizi

Aghemo

Fogazzi

et al. 2013

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…Treatment with IFN-␣ has been associated with development of proteinuria, although, at least in the context of hepatitis C, this may represent exacerbation of preexisting glomerulonephritis. 25 Development of nephrotic syndrome with histologic types including minimal-change disease and FSGS has also been described; however, such sporadic cases seem to be due to individual idiosyncrasies rather than to predictable dosage-dependent effects. There may be important differences between IFN-␤ and IFN-␣ in this respect, because we could identify only one case of nephrotic syndrome developing in response to IFN-␤ despite its wide use in the treatment of multiple sclerosis.…”

Section: Discussionmentioning

confidence: 99%

Interferon-β Reduces Proteinuria in Experimental Glomerulonephritis

Satchell

Buchatska²,

Khan³

et al. 2007

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Interferon-␤ (IFN-␤) is a multifunctional cytokine with immunomodulatory properties. We examined the effect of IFN-␤ in three separate rat models of glomerular injury and in cultured human glomerular endothelial cells and podocytes. In nephrotoxic nephritis in WKY rats, recombinant rat IFN-␤ started either at induction or after establishment of disease significantly reduced 24-h proteinuria by up to 73% and 51%, respectively, but did not affect serum creatinine. There was a slight reduction in numbers of glomerular macrophages, but no difference in glomerular or tubulointerstitial scarring. In Thy-1 nephritis in Lewis rats, IFN-␤ started at induction of disease reduced proteinuria by up to 66% with no effect on numbers of glomerular macrophages, but a reduced number of proliferating cells. In puromycin nephropathy in Wistar rats, IFN-␤ started at induction of disease reduced proteinuria by up to 93%, but had no effect on glomerular histology. In cultured cells, human IFN-␤-1a had a dramatic effect on barrier properties, increasing electrical resistance across monolayers of either glomerular endothelial cells or podocytes and decreasing trans-monolayer passage of albumin. In conclusion, these results show that IFN-␤ reduces proteinuria in three different rat models of glomerular injury and that its anti-proteinuric action may result from direct effects on cells that comprise the glomerular filtration barrier. These data indicate that IFN-␤ may have potential as a therapeutic agent in proteinuric renal disease.

show abstract

“…Another problem is that the optimal dose and duration of IFN-a to achieve an appropriate renal response has not been evaluated. In addition, IFN-a itself has been reported to be nephrotoxic (16). Therefore, the long-term efficacy of IFN-a for HCV-associated cryoglobulinemic GNis still controversial.…”

Section: Discussionmentioning

confidence: 99%

Cryofiltration and Oral Corticosteroids Provide Successful Treatment for an Elderly Patient with Cryoglobulinemic Glomerulonephritis Associated with Hepatitis C Virus Infection.

et al. 2000

View full text Add to dashboard Cite

A 75-year-old manwas admitted due to nephrotic syndrome, purpura on the legs, which was associated with hepatitis C virus (HCV), and type II mixed cryoglobulinemia. Renal biopsy revealed features of cryoglobulinemic glomerulonephritis. Since the patient was elderly and the HCV genotype was Ib, interferon-alpha for reducing HCVwas not indicated. Four sessions of cryofiltration and the administration of corticosteroids improved the proteinuria and renal function strikingly without adverse effects. This case demonstrates that an elderly patient who has nephrotic syndrome caused by cryoglobulinemic glomerulonephritis associated with HCVcan be treated safely by cryofiltration with low doses of oral corticosteroids.

show abstract

Exacerbation of glomerulonephritis in subjects with chronic hepatitis C virus infection after interferon therapy

Cited by 73 publications

References 25 publications

Acute Tubular Necrosis Following Interferon-Based Therapy for Hepatitis C: Case Study with Literature Review

Acute Tubular Necrosis Following Interferon-Based Therapy for Hepatitis C: Case Study with Literature Review

Interferon-β Reduces Proteinuria in Experimental Glomerulonephritis

Cryofiltration and Oral Corticosteroids Provide Successful Treatment for an Elderly Patient with Cryoglobulinemic Glomerulonephritis Associated with Hepatitis C Virus Infection.

Contact Info

Product

Resources

About