Ex vivo investigation of magnetically targeted drug delivery system

Yoshida, Yuki; Fukui, Satoshi; Fujimoto, Suketaka; Mishima, Fumihito; Takeda, Shin‐ichi; Izumi, Yoshinobu; Ohtani, S.; Fujitani, Yoshio; Nishijima, Shigehiro

doi:10.1016/j.jmmm.2006.11.123

Cited by 34 publications

(14 citation statements)

References 2 publications

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“…The development of uniform magnetic nanoparticles (MNPs) has been intensively pursued for their scientific and technological importance [1][2][3]. The synthesis of MNPs with average sizes from 2 to 50 nm is of significant importance because of their applications in several fields, especially in biomedicine for magnetic resonance imaging (MRI) [4,5], cell labelling [6,7], and drug delivery [8][9][10][11]. Of special interest are their magnetic properties in which the differences between a massive or bulk material and a nanoscaled one are especially pronounced.…”

Section: Introductionmentioning

confidence: 99%

Size‐Controlled Synthesis of CoFe₂O₄ Nanoparticles Potential Contrast Agent for MRI and Investigation on Their Size‐Dependent Magnetic Properties

Liu

Laurent

Roch

et al. 2013

Journal of Nanomaterials

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Cobalt ferrite nanoparticles (CoFe2O4NPs) were synthesized by coprecipitation followed by treatments with diluted nitric acid and sodium citrate. Transmission electron microscope (TEM) and photon correlation spectroscopy (PCS) characterization showed that the size distributions of these nanoparticles were monodisperse and that no aggregation occurred. This colloid showed a long-term stability. Through adjustment of the concentrations of reactants and reaction temperature, the size of the NPs can be tuned from 6 to 80 nm. The size-control mechanism is explained by a nucleation-growth model, where the local concentration of monomers is assumed to decide the size of nuclei, and reaction temperatures influence the growth of nuclei. Magnetization and relaxivityr1,2measurements showed that the NPs revealed size-dependent magnetization and relaxivity properties, which are explained via a “dead magnetic layer” theory where reductions of saturation magnetization (Ms) andr1,2are assumed to be caused by the demagnetization of surface spins.

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Section: Introductionmentioning

confidence: 99%

Size‐Controlled Synthesis of CoFe₂O₄ Nanoparticles Potential Contrast Agent for MRI and Investigation on Their Size‐Dependent Magnetic Properties

Liu

Laurent

Roch

et al. 2013

Journal of Nanomaterials

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“…This is attributed to its broad range of applications especially in biomedical applications such as cellular therapy in cell labelling [1,2], targeted drug delivery [3], selective protein separation [4,5], MRI contrast agent [6,7] and hyperthermia in cancer treatment [8,9].…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents

Haw

Mohamed

Chia

et al. 2010

Ceramics International

150

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Magnetite (Fe 3 O 4 ) nanoparticles prepared using hydrothermal approach were employed to study their potential application as magnetic resonance imaging (MRI) contrast agent. The hydrothermal process involves precursors FeCl 2 Á4H 2 O and FeCl 3 with NaOH as reducing agent to initiate the precipitation of Fe 3 O 4 , followed by hydrothermal treatment to produce nano-sized Fe 3 O 4 . Chitosan (CTS) was coated onto the surface of the as-prepared Fe 3 O 4 nanoparticles to enhance its stability and biocompatible properties. The size distribution of the obtained Fe 3 O 4 nanoparticles was examined using transmission electron microscopy (TEM). The cubic inverse spinel structure of Fe 3 O 4 nanoparticles was confirmed by X-ray diffraction technique (XRD). Fourier transform infrared (FTIR) spectrum indicated the presence of the chitosan on the surface of the Fe 3 O 4 nanoparticles. The superparamagnetic behaviour of the produced Fe 3 O 4 nanoparticles at room temperature was elucidated using a vibrating sample magnetometer (VSM). From the result of custom made phantom study of magnetic resonance (MR) imaging, coated Fe 3 O 4 nanoparticles have been proved to be a promising contrast enhanced agent in MR imaging. #

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“…The animal experiment using rat was performed [14]. As a Yshaped blood vessel the abdominal aorta branching to right and left ileum artery was chosen.…”

Section: Magnetic Drug Delivery System Using Bulk High Temperature Sumentioning

confidence: 99%

Ex vivo investigation of magnetically targeted drug delivery system

Cited by 34 publications

References 2 publications

Size‐Controlled Synthesis of CoFe₂O₄ Nanoparticles Potential Contrast Agent for MRI and Investigation on Their Size‐Dependent Magnetic Properties

Size‐Controlled Synthesis of CoFe₂O₄ Nanoparticles Potential Contrast Agent for MRI and Investigation on Their Size‐Dependent Magnetic Properties

Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents

Application of superconductivity for magnetic force control in medical and industrial fields

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Ex vivo investigation of magnetically targeted drug delivery system

Cited by 34 publications

References 2 publications

Size‐Controlled Synthesis of CoFe2O4 Nanoparticles Potential Contrast Agent for MRI and Investigation on Their Size‐Dependent Magnetic Properties

Size‐Controlled Synthesis of CoFe2O4 Nanoparticles Potential Contrast Agent for MRI and Investigation on Their Size‐Dependent Magnetic Properties

Hydrothermal synthesis of magnetite nanoparticles as MRI contrast agents

Application of superconductivity for magnetic force control in medical and industrial fields

Contact Info

Product

Resources

About

Size‐Controlled Synthesis of CoFe₂O₄ Nanoparticles Potential Contrast Agent for MRI and Investigation on Their Size‐Dependent Magnetic Properties

Size‐Controlled Synthesis of CoFe₂O₄ Nanoparticles Potential Contrast Agent for MRI and Investigation on Their Size‐Dependent Magnetic Properties