Ex Vivo Breast Tumor Identification: Advances Toward a Silicon-Based Terahertz Near-Field Imaging Sensor

Pfeiffer, Ullrich R.; Hillger, Philipp; Jain, Ritesh; Grzyb, Janusz; Bücher, Thomas; Cassar, Quentin; MacGrogan, Gaëtan; Guillet, Jean-Paul; Mounaix, Patrick; Zimmer, Thomas

doi:10.1109/mmm.2019.2922119

Cited by 20 publications

(13 citation statements)

References 56 publications

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“…However, the image recording in reflection mode, when the surface is rough, causes tremendous difficulties [345], hence needing special technological and computing approaches. As a result, compact near-field THz imaging systems are currently getting more preference, for instance, in biomedical applications [347].…”

Section: Thz Light-field Imaging Techniquementioning

confidence: 99%

Roadmap of Terahertz Imaging 2021

Valušis

Lisauskas

Yuan

et al. 2021

Sensors

157

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In this roadmap article, we have focused on the most recent advances in terahertz (THz) imaging with particular attention paid to the optimization and miniaturization of the THz imaging systems. Such systems entail enhanced functionality, reduced power consumption, and increased convenience, thus being geared toward the implementation of THz imaging systems in real operational conditions. The article will touch upon the advanced solid-state-based THz imaging systems, including room temperature THz sensors and arrays, as well as their on-chip integration with diffractive THz optical components. We will cover the current-state of compact room temperature THz emission sources, both optolectronic and electrically driven; particular emphasis is attributed to the beam-forming role in THz imaging, THz holography and spatial filtering, THz nano-imaging, and computational imaging. A number of advanced THz techniques, such as light-field THz imaging, homodyne spectroscopy, and phase sensitive spectrometry, THz modulated continuous wave imaging, room temperature THz frequency combs, and passive THz imaging, as well as the use of artificial intelligence in THz data processing and optics development, will be reviewed. This roadmap presents a structured snapshot of current advances in THz imaging as of 2021 and provides an opinion on contemporary scientific and technological challenges in this field, as well as extrapolations of possible further evolution in THz imaging.

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Section: Thz Light-field Imaging Techniquementioning

confidence: 99%

Roadmap of Terahertz Imaging 2021

Valušis

Lisauskas

Yuan

et al. 2021

Sensors

157

View full text Add to dashboard Cite

show abstract

“…Nevertheless, there have been studies showing near-field THz imaging of biosamples. 56,[86][87][88][89][90][91][92][93][94][95] These references use different systems and will be discussed below.…”

Section: Microscopy and The Near-fieldmentioning

confidence: 99%

Terahertz (THz) biophotonics technology: Instrumentation, techniques, and biomedical applications

Chen

Lindley-Hatcher

Stantchev

et al. 2022

Chemical Physics Reviews

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Terahertz (THz) technology has experienced rapid development in the past two decades. Growing numbers of interdisciplinary applications are emerging, including materials science, physics, communications, and security as well as biomedicine. THz biophotonics involves studies applying THz photonic technology in biomedicine, which has attracted attention due to the unique features of THz waves, such as the high sensitivity to water, resonance with biomolecules, favorable spatial resolution, capacity to probe the water–biomolecule interactions, and nonionizing photon energy. Despite the great potential, THz biophotonics is still at an early stage of development. There is a lack of standards for instrumentation, measurement protocols, and data analysis, which makes it difficult to make comparisons among all the work published. In this article, we give a comprehensive review of the key findings that have underpinned research into biomedical applications of THz technology. In particular, we will focus on the advances made in general THz instrumentation and specific THz-based instruments for biomedical applications. We will also discuss the theories describing the interaction between THz light and biomedical samples. We aim to provide an overview of both basic biomedical research as well as pre-clinical and clinical applications under investigation. The paper aims to provide a clear picture of the achievements, challenges, and future perspectives of THz biophotonics.

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“…Overall, the global difference between these values was shown to be the highest between 300- and 700-GHz, roughly. Hence, rather than investigating the entire band, the classification was operated at 550-GHz, as a good trade-off between signal-to-noise ratio (SNR) and higher frequency spatial resolution 45 . However, naively classifying pixels via the refractive index exhibited at 550-GHz may hardly be relevant.…”

Section: Refractive Index Mapmentioning

confidence: 99%

Terahertz refractive index-based morphological dilation for breast carcinoma delineation

Cassar

Caravera

MacGrogan

et al. 2021

Sci Rep

Self Cite

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This paper reports investigations led on the combination of the refractive index and morphological dilation to enhance performances towards breast tumour margin delineation during conserving surgeries. The refractive index map of invasive ductal and lobular carcinomas were constructed from an inverse electromagnetic problem. Morphological dilation combined with refractive index thresholding was conducted to classify the tissue regions as malignant or benign. A histology routine was conducted to evaluate the performances of various dilation geometries associated with different thresholds. It was found that the combination of a wide structuring element and high refractive index was improving the correctness of tissue classification in comparison to other configurations or without dilation. The method reports a sensitivity of around 80% and a specificity of 82% for the best case. These results indicate that combining the fundamental optical properties of tissues denoted by their refractive index with morphological dilation may open routes to define supporting procedures during breast-conserving surgeries.

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Ex Vivo Breast Tumor Identification: Advances Toward a Silicon-Based Terahertz Near-Field Imaging Sensor

Cited by 20 publications

References 56 publications

Roadmap of Terahertz Imaging 2021

Roadmap of Terahertz Imaging 2021

Terahertz (THz) biophotonics technology: Instrumentation, techniques, and biomedical applications

Terahertz refractive index-based morphological dilation for breast carcinoma delineation

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