Terahertz refractive index-based morphological dilation for breast carcinoma delineation

Cassar, Quentin; Caravera, Samuel; MacGrogan, Gaëtan; Bücher, Thomas; Hillger, Philipp; Pfeiffer, Ullrich R.; Zimmer, Thomas; Guillet, Jean-Paul; Mounaix, Patrick

doi:10.1038/s41598-021-85853-8

Cited by 20 publications

(11 citation statements)

References 53 publications

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“…Terahertz time-domain spectroscopy (THz-TDS) has emerged as a noninvasive and objective tool for assessment of various biological tissue types, including determining corneal hydration 29 – 32 , diagnosis of brain tumors 33 – 35 , diabetic foot syndrome 36 , delineating breast cancer tumor margins 37 – 41 , and classification of burn injuries 42 , 43 . In burn diagnosis applications, it was shown that the reflectivity of the full-thickness burns in rodent models is higher compared to the normal skin over a frequency range between 0.2 and 1 THz 44 .…”

Section: Introductionmentioning

confidence: 99%

Supervised machine learning for automatic classification of in vivo scald and contact burn injuries using the terahertz Portable Handheld Spectral Reflection (PHASR) Scanner

Khani

Harris

Osman

et al. 2022

Sci Rep

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We present an automatic classification strategy for early and accurate assessment of burn injuries using terahertz (THz) time-domain spectroscopic imaging. Burn injuries of different severity grades, representing superficial partial-thickness (SPT), deep partial-thickness (DPT), and full-thickness (FT) wounds, were created by a standardized porcine scald model. THz spectroscopic imaging was performed using our new fiber-coupled Portable HAndheld Spectral Reflection Scanner, incorporating a telecentric beam steering configuration and an f-$$\theta$$ θ scanning lens. ASynchronous Optical Sampling in a dual-fiber-laser THz spectrometer with 100 MHz repetition rate enabled high-speed spectroscopic measurements. Given twenty-four different samples composed of ten scald and ten contact burns and four healthy samples, supervised machine learning algorithms using THz-TDS spectra achieved areas under the receiver operating characteristic curves of 0.88, 0.93, and 0.93 when differentiating between SPT, DPT, and FT burns, respectively, as determined by independent histological assessments. These results show the potential utility of our new broadband THz PHASR Scanner for early and accurate triage of burn injuries.

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Section: Introductionmentioning

confidence: 99%

Supervised machine learning for automatic classification of in vivo scald and contact burn injuries using the terahertz Portable Handheld Spectral Reflection (PHASR) Scanner

Khani

Harris

Osman

et al. 2022

Sci Rep

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“…In a recent study as reported in [119], the authors have used a combination of morphological dilation and refractive index thresholding to classify malignant and benign breast tissues so as to enhance the performance of tumor margin delineation for conserving surgeries. The image acquisition has been performed employing TPS3000 THz system in reflection mode.…”

Section: A: Materials and Methodsmentioning

confidence: 99%

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Gezimati

Singh

2023

IEEE Access

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There is a keen interest in the exploration of new generation emitters and detectors due to advancements in innovation of new materials and device processing technologies which have opened up new frontiers in the Terahertz (THz) spectrum. Therefore, it is necessary to review the developments in THz technology for healthcare applications, their impact, implications and prospects for ongoing research and development. This paper provides a broad overview of the current status and prospects of application of THz imaging and sensing for the healthcare domain. We present current knowledge, identify existing challenges for wide scale clinical adoption of THz systems and prospective opinions to facilitate research and development towards optimized and miniaturized THz systems and biosensors that provide real operational convenience through emerging trends. Firstly, we provide an overview of the THz imaging and sensing techniques that exploit properties of THz generation and detection with emphasis on terahertz time domain spectroscopy (THz-TDS) and THz Metamaterials. The mechanisms of tissue image contrast and the application of THz imaging and sensing for biomedical applications in particular, the cancer detection application is reported. Secondly, an outlook toward the advancements in THz technology in the interface of healthcare 4.0 and its enabling technologies is explored for next generation smart and connected healthcare systems. Third, we identify the merits and existing challenges in THz cancer imaging and sensing and suggest prospective opinions to pave way to ongoing and future research. Further, we discuss the recent advances in THz imaging development and the contribution of near-field techniques based on plasmonic, and resonance based metasurfaces, waveguides etc. for breaking the diffraction limit towards development of THz systems that are convenient for point of care. We bring researchers a roadmap for future research scope.

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“…In 2021, Cassar et al studied the combination of the refractive index and morphological dilation to improve performances towards breast tumor margin delineation during breast-conserving surgeries [ 92 ]. In this study, morphological dilation combined with the refractive index approach was applied for tissue classification.…”

Section: Chemometrics Methods In Thz Imagingmentioning

confidence: 99%

Terahertz Imaging for Breast Cancer Detection

Wang

2021

Sensors

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Terahertz (THz) imaging has the potential to detect breast tumors during breast-conserving surgery accurately. Over the past decade, many research groups have extensively studied THz imaging and spectroscopy techniques for identifying breast tumors. This manuscript presents the recent development of THz imaging techniques for breast cancer detection. The dielectric properties of breast tissues in the THz range, THz imaging and spectroscopy systems, THz radiation sources, and THz breast imaging studies are discussed. In addition, numerous chemometrics methods applied to improve THz image resolution and data collection processing are summarized. Finally, challenges and future research directions of THz breast imaging are presented.

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Terahertz refractive index-based morphological dilation for breast carcinoma delineation

Cited by 20 publications

References 53 publications

Supervised machine learning for automatic classification of in vivo scald and contact burn injuries using the terahertz Portable Handheld Spectral Reflection (PHASR) Scanner

Supervised machine learning for automatic classification of in vivo scald and contact burn injuries using the terahertz Portable Handheld Spectral Reflection (PHASR) Scanner

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Terahertz Imaging for Breast Cancer Detection

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