Ex vivo and in vivo studies of Viola tricolor Linn. as potential cardio protective and hypotensive agent: Inhibition of voltage‐gated Ca ⁺⁺ ion channels

Viola tricolor Hydroalcoholic Extract Improves Behavioral Deficiencies in Rats Exposed to Chronic Immobilization Stress

“…This effect is probably due to its compounds, such as rutin, lutein, and βcarotene in V. tricolor [22][23][24]. The anti-inflammatory effect of V. tricolor has been confirmed by in vitro and in vivo several studies [15,25]. IL-10 is an anti-inflammatory cytokine, unlike IL-6 [26].…”

“…-Viola300 & Viola600: they received a hydro-alcoholic extract of V. tricolor in doses of 300 or 600 mg/kg by gavage for 21 consecutive days [15].…”

“…Then the extract was diluted with distilled water for gavage administration. Here, to determine the dose of the extract, we used the Saqib and coauthors study on the cardioprotective effect of the V. tricolor extract [15]. The volume of each oral gavage was 2 mL/kg body weight.…”