ex differences in immune responses to cephalothin in guinea pigs.

Aida, Tetsuo; Ishikawa, N; Shinkai, Kenkichi

doi:10.2131/jts.23.87

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“…In general, females induce a stronger immune response because they express higher levels of lymphocytes and cytokines (3,5,16). Susceptibilities to encephalomyocarditis virus (9), vesicular stomatitis virus (4), coxsackievirus B3 (15), and HSV-1 infections in mice (13) differ based on gender.…”

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confidence: 99%

The Herpes Simplex Virus Type 1 Locus That Encodes the Latency-Associated Transcript Enhances the Frequency of Encephalitis in Male BALB/c Mice

Jones

Inman

Peng

et al. 2005

J Virol

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Herpes simplex virus type 1 (HSV-1) is the leading cause of virus-induced encephalitis; however, the viral genes that regulate encephalitis have not been well characterized. In this study, we tested whether the LAT (latency-associated transcript) locus regulates the frequency of encephalitis in male or female mice. Male BALB/c mice are more susceptible to HSV-1-induced encephalitis than age-matched female BALB/c mice. Deletion of LAT coding sequences reduced the frequency of encephalitis. A recombinant virus containing the first 1.5 kb of the LAT coding sequence induces levels of encephalitis in male BALB/c mice similar to those induced by wild-type HSV-1.

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confidence: 99%