Ewing's sarcoma of the mandible in a young child

Brazão–Silva, Marco Túllio; Fernandes, Alexandre Vieira; Faria, Paulo Rogério de; Cardoso, Sérgio Vitorino; Loyola, Adriano Mota

doi:10.1590/s0103-64402010000100012

Cited by 36 publications

(61 citation statements)

References 19 publications

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“…20 The Mic-2 gene product (CD99) for all Ewing's Sarcoma family tumors with over 95% of the cases show positivity for this marker. 21 In our case, CD99 and NSE were identified to be positive.…”

Section: Discussionsupporting

confidence: 48%

Imaging Features of Primitive Neuroectodermal Tumor in the Maxilla: A Case Report and Literature Review

Bozdemir¹,

Fındık²,

Bilgir³

et al. 2016

Turkiye Klinikleri J Dental Sci Cases

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106rimitive neuroectodermal tumor (PNET) is a term used to describe a group of highly rare and malignant neoplasms composed of undifferentiated round cell tumors of neuroectodermal origin with variable cell differentiation. PNET generally occurs in the central nervous system (CNS); peripheral PNET occurring outside the CNS has also been reported. Peripheral PNET is commonly related to Ewing's sarcoma (ES). However, it exhibits a more aggressive clinical behavior than ES, with extremely rapid metastasis. PNET has a poor prognosis and is commonly seen in children and young adults.1 Because this tumor presents aggressive biological behavior and tends toward loco-regional and systemic metastases, it is a tumor with an extremely poor survival rate.2 The incidence of head and neck PNET Imaging Features of Primitive Neuroectodermal Tumor in the Maxilla: A Case Report and Literature Review A AB BS S T TR RA AC CT T Primitive neuroectodermal tumor (PNET) is a term used to describe a group of highly malignant neoplasms composed of undifferentiated round cell tumors of neuroectodermal origin with variable cell differentiation. PNET generally occurs in the central nervous system (CNS), but peripheral PNET occurring outside the CNS has also been reported. The most common location of PNET in head and neck region is the orbit, followed by the neck and the parotid gland. PNET of the maxilla is rare. The aims of this report are to present the case of a 41-year-old female diagnosed with PNET tumor of the maxilla after detailed clinical, radiological, and histopathological examinations and to review the previously reported cases of PNET of the maxilla in the literature.K Ke ey y W Wo or rd ds s: : Neuroectodermal tumors, primitive, peripheral; maxilla; diagnosis; cone-beam computed tomography Ö ÖZ ZE ET T Primitif nöroektodermal tümör (PNET), nöroektodermal kökenli farklılaşmamış yuvarlak hücreli tümörlerden oluşan son derece malign tümörlerin bir grubunu tanımlamak için kullanılan bir terimdir. PNET genellikle santral sinir sisteminde meydana gelir fakat santral sinir sistemi dışında ortaya çıkan periferal PNET olguları da rapor edilmiştir. Baş-boyun bölgesinde en fazla gözde görülür. Gözden sonra en sık boyun ve parotis bezinde görülür. Maksilladaki PNET nadirdir. Bu raporun amacı detaylı klinik, radyolojik ve histopatolojik incelemeden sonra maksillada PNET tanısı koyulan 41 yaşında kadın hastayı sunmak ve literatürde daha önce rapor edilen maksilladaki PNET vakalarını incelemektir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Nöroektodermal tümörler, primitif, periferik; maksilla; tanı; konik ışınlı bilgisayarlı tomografi T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J D De en nt ta al l S Sc ci i C Ca as se es s 2 20 01 16 6; ;2 2( (3 3) ): :1 10 06 6--1 12 2

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Section: Discussionsupporting

confidence: 48%

Imaging Features of Primitive Neuroectodermal Tumor in the Maxilla: A Case Report and Literature Review

Bozdemir¹,

Fındık²,

Bilgir³

et al. 2016

Turkiye Klinikleri J Dental Sci Cases

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“…Recently, it has been shown that high levels of CD133 expression in Ewing sarcoma cells are associated with chemoresistant Ewing sarcoma. 7 Therefore, CD133 could be a regarded as a marker for predicting which cases of Ewing sarcoma benefit more from preoperative chemotherapy and which cases benefit more from early surgical intervention. However, this is only a tentative suggestion requiring more intense experimentation to evaluate its usefulness in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Ewing Sarcoma of the Jaws

Karimi¹,

Shirinbak²,

Beshkar³

et al. 2011

Journal of Craniofacial Surgery

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Three cases of Ewing sarcoma in the jaw bones are presented. The first patient is a 43-year-old woman with a rapidly growing tumor in the hard palate. The second patient is a 9-year-old girl with tumor in the left mandibular ramus and body. In both patients, the tumors were excised with significant safe margins. However, postoperative histopathologic evaluation revealed the presence of tumor cells in bony margins, necessitating a second surgery. The third patient is a 9-year-old boy with tumor in the right mandibular ramus and body. In patients 1 and 2, chemotherapy failed to control the tumor; however, in patient 3, chemotherapy resulted in significant shrinkage of the tumor and no further growth.

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“…), CD31 and CD 34 (vascular tumors) Ki67 (breast cancer) synaptophysin (neuroblastoma) is also a diagnostic criteria for ES. 6 An additional translocation {t (11; 22) (q24; q12)} has been reported in other studies as a supportive data. Due to the non-availability, chromosomal analysis of bone marrow sample is not done in our study.…”

Section: Discussionmentioning

confidence: 55%

“…6 The diagnosis of ES is difficult due to its characteristic similarity with other malignant tumors. 7 A gradual increase of pain is one of the major symptoms of bone sarcomas.…”

Section: Discussionmentioning

confidence: 99%