Abstract. Let D be a bounded, smooth enough domain of R 2 . For L > 0 consider the continuous time, zero-temperature heat bath dynamics for the nearest-neighbor Ising model on (Z/L) 2 (the square lattice with lattice spacing 1/L) with initial condition such that σx = −1 if x ∈ D and σx = +1 otherwise. We prove the following classical conjecture [24,5] due to H. Spohn: In the diffusive limit where time is rescaled by L 2 and L → ∞, the boundary of the droplet of "−" spins follows a deterministic anisotropic curve-shortening flow, such that the normal velocity is given by the local curvature times an explicit function of the local slope. Locally, in a suitable reference frame, the evolution of the droplet boundary follows the onedimensional heat equation.To our knowledge, this is the first proof of mean curvature-type droplet shrinking for a lattice model with genuine microscopic dynamics.An important ingredient is our recent work [20], where the case of convex D was solved. The other crucial point in the proof is obtaining precise regularity estimates on the deterministic curve shortening flow. This builds on geometric and analytic ideas of Grayson [16], GageHamilton [15], Gage-Li [13,14], Chou-Zhu [6] and others.