Evolutionary genetics of canine respiratory coronavirus and recent introduction into Swedish dogs

Wille, Michelle; Wensman, Jonas Johansson; Larsson, Simon; Damme, Renaud Van; Theelke, Anna-Karin; Hayer, Juliette; Malmberg, Maja

doi:10.1016/j.meegid.2020.104290

Cited by 12 publications

(19 citation statements)

References 52 publications

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“…As is true of SARS CoV-2, CRCoV can also be associated with more severe clinical signs, inappetence, and bronchopneumonia. Disease occurs most frequently in fall to winter months [130], and populations most at risk are dogs densely housed in shelter, kennel, or group environments [131]. CRCoV has been proposed as a naturally occurring animal model of SARS-CoV-2 infection in humans, due to parallels in pathogenesis and early host immune response [132].…”

Section: Epidemiology and Clinical Featuresmentioning

confidence: 99%

Coronavirus Infections in Companion Animals: Virology, Epidemiology, Clinical and Pathologic Features

Haake

Cook

Pusterla

et al. 2020

Viruses

140

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Coronaviruses are enveloped RNA viruses capable of causing respiratory, enteric, or systemic diseases in a variety of mammalian hosts that vary in clinical severity from subclinical to fatal. The host range and tissue tropism are largely determined by the coronaviral spike protein, which initiates cellular infection by promoting fusion of the viral and host cell membranes. Companion animal coronaviruses responsible for causing enteric infection include feline enteric coronavirus, ferret enteric coronavirus, canine enteric coronavirus, equine coronavirus, and alpaca enteric coronavirus, while canine respiratory coronavirus and alpaca respiratory coronavirus result in respiratory infection. Ferret systemic coronavirus and feline infectious peritonitis virus, a mutated feline enteric coronavirus, can lead to lethal immuno-inflammatory systemic disease. Recent human viral pandemics, including severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and most recently, COVID-19, all thought to originate from bat coronaviruses, demonstrate the zoonotic potential of coronaviruses and their potential to have devastating impacts. A better understanding of the coronaviruses of companion animals, their capacity for cross-species transmission, and the sharing of genetic information may facilitate improved prevention and control strategies for future emerging zoonotic coronaviruses. This article reviews the clinical, epidemiologic, virologic, and pathologic characteristics of nine important coronaviruses of companion animals.

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Section: Epidemiology and Clinical Featuresmentioning

confidence: 99%

Coronavirus Infections in Companion Animals: Virology, Epidemiology, Clinical and Pathologic Features

Haake

Cook

Pusterla

et al. 2020

Viruses

140

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“…Genetikai szempontból az összehasonlítást az ugyanazon nemzetségbe tartozó vírusokkal érdemes kezdeni, melyek közül a kutya légzőszervi koronavírusa (CRCoV) tűnik ideális választásnak, megegyező szervtropizmusa miatt [37]. Ugyanakkor a CRCoV a SARS-CoV-2-vel szemben önállóan legfeljebb minimális tüneteket indukál; egyéb kórokozókkal együttesen alakíthatja ki a kennelköhögés néven ismert, általában menhelyeken vagy versenyeken összezsúfolódott kutyák közt előforduló, komplex légzőszervi betegséget [38]. Genetikailag pedig inkább a HCoV-OC43-mal és a BCoV-vel mutat szoros rokonságot.…”

Section: Tanulságok Az áLlatvilágbólunclassified

A súlyos akut légzőszervi szindrómát okozó koronavírus-2 (SARS-CoV-2) orvosilag releváns aspektusai állatokban

Valkó

Medgyaszai

2021

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Összefoglaló. A mikroszkóp felfedezése óta tudjuk, hogy az egymással szoros közelségben élő egyedeknek nem csupán a látható élőhelyük közös, hanem szemmel nem érzékelhető mikroorganizmusokat is megosztanak egymással, melyek bizonyos fokban adaptálódtak gazdáikhoz. Az emberek életterének bővülésével és ezzel párhuzamosan az állatok élőhelyének csökkenésével azonban új állatfajok kerülhetnek veszélyes közelségbe, ami következményes mikrobaátadással és az új gazdában a mikroba eltérő viselkedésével járhat. Feltételezhetően ez a jelenség vezetett a súlyos akut légzőszervi szindróma koronavírus-2 (SARS-CoV-2) kialakulásához, mely 2019-ben jelent meg először emberekben, és néhány hónap leforgása alatt milliókat fertőzött meg az egész világon. A pandémia leküzdéséhez és az újabb járványok megelőzéséhez minden lehetséges eszközt fel kell használni, ami együttműködést kíván a humánorvoslás és az állatgyógyászat, valamint az ökológiai, evolúciós és környezeti tudományok szakemberei között a globális „Egy Egészség” keretében. A közös célok érdekében történő összefogás jegyében a jelen tanulmány állatorvos és humánorvos szerzőpárosa összefoglalja azon ismereteket, amelyek a SARS-CoV-2 vonatkozásában mindkét szakma számára érdemlegesek lehetnek. Bemutatásra kerül a vírus eredete, természetes és mesterséges előfordulása különböző állatfajokban, valamint az állati koronavírusokkal kapcsolatos azon tapasztalatok, amelyek hozzájárulhatnak a SARS-CoV-2 működésének megértéséhez és az ellene való védekezés tökéletesítéséhez. Orv Hetil. 2021; 162(5): 163–170. Summary. Introduction: Since the discovery of the microscope, we have known that individuals living in close proximity to each other share not only their visible habitat, but also invisible microorganisms that have adapted to some degree to their hosts. However, as human habitat expands and, in parallel, animal territory declines, new animal species can come into dangerous proximity, which may result in consequential transmission of microbes and different microbial behaviour in the new host. Presumably, this phenomenon led to the development of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first appeared in humans in 2019 and infected millions over the course of a few months worldwide. All possible means must be used to combat the pandemic and prevent further epidemics, which will require cooperation between professionals in human medicine and veterinary medicine as well as in the ecological, evolutionary and environmental sciences, within the framework of the global “One Health”. In a spirit of working together for common goals, the authors of this study, a veterinarian and a human physician, summarize the knowledge that may be relevant to both professions for SARS-CoV-2. The origin of the virus, its natural and artificial occurrence in different animal species, and experiences with animal coronaviruses that may contribute to the understanding of the functioning of SARS-CoV-2 and the development of protection against it are presented. Orv Hetil. 2021; 162(5): 163–170.

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“…This virus is a deletion mutant of the more pathogenic transmissible gastroenteritis virus (TGEV), and the spread of PRCV has provided a beneficial cross-protection in the pig population [14]. CRCoV and BCoV belong to the genus Betacoronavirus (subgenus Embecovirus), and are genetically similar to each other and to the human coronavirus (HCoV) OC43 [15]. In fact, all three viruses are classified as the same species, Betacoronavirus 1, and recombination events among viruses in this species occur [16].…”

Section: Animal Coronaviral Diseases That Could Be Relevant As a Modementioning

confidence: 99%

“…Arises from mutations of the benign feline enteric coronavirus in the individual cat [12] Deletion mutant of the more pathogenic transmissible gastroenteritis virus (TGEV) [14] Genetically similar to bovine coronavirus (BCoV) and human coronavirus (HCoV) OC43 [15] Genetically similar to canine respiratory coronavirus (CRCoV) and…”

Section: Disease Characteristicsmentioning

confidence: 99%

“…HCoV OC43 [15,25] Genetically similar to bat SARS-like CoVs [26] Tropism Multiple, mainly monocytes/macrophages [11] Respiratory tract (epithelial cells and alveolar macrophages) [13,14] Mainly respiratory tract [17] Respiratory and gastrointestinal tract [10] Respiratory and gastrointestinal tract (incl. epithelial cells and alveolar macrophages) [23,24,27,28] Vaccine?…”

Section: Disease Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine Model

Wensman

Stokstad

2020

Pathogens

Self Cite

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The current pandemic of COVID-19 has highlighted the importance of basic studies on coronaviruses (CoVs) in general, and severe acute respiratory syndrome CoV type 2 (SARS-CoV-2) in particular. CoVs have for long been studied in veterinary medicine, due to their impact on animal health and welfare, production, and economy. Several animal models using coronaviral disease in the natural host have been suggested. In this review, different animal models are discussed, with the main focus on bovine CoV (BCoV). BCoV is endemic in the cattle population worldwide and has been known and studied for several decades. SARS-CoV-2 and BCoV are both betacoronaviruses, where BCoV is highly similar to human coronavirus (HCoV) OC43, encompassing the same virus species (Betacoronavirus 1). BCoV causes respiratory and gastrointestinal disease in young and adult cattle. This review summarizes the current knowledge of the similarities and dissimilarities between BCoV and SARS-CoV-2, as well as discussing the usage of BCoV as a model for human CoVs, including SARS-CoV-2.

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Evolutionary genetics of canine respiratory coronavirus and recent introduction into Swedish dogs

Cited by 12 publications

References 52 publications

Coronavirus Infections in Companion Animals: Virology, Epidemiology, Clinical and Pathologic Features

Coronavirus Infections in Companion Animals: Virology, Epidemiology, Clinical and Pathologic Features

A súlyos akut légzőszervi szindrómát okozó koronavírus-2 (SARS-CoV-2) orvosilag releváns aspektusai állatokban

Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine Model

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