Proceedings of the 9th Annual Conference on Genetic and Evolutionary Computation 2007
DOI: 10.1145/1276958.1277045
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Evolutionary approach to protein structure prediction with hydrophobic interactions

Abstract: The Protein Structure Prediction (PSP) is to determine the protein tertiary structure from its amino acids. This paper presents the ProtPred and investigates its application. The first results showed that ProtPred is a consistent approach.

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Cited by 6 publications
(7 citation statements)
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“…Despite the efforts of the in silico methods in trying to find the correct protein configurations, an appropriate algorithm that can work properly in a pure ab initio way is still missing, which is especially relevant when one wants to predict a protein that has low similarity with the known structures. There are some Evolutionary Algorithms (EA) and other optimization approaches with useful results for PSP [6,7,8,9]. The better the optimization technique, the better will be its chances of finding proper solutions.…”
Section: Introductionmentioning
confidence: 99%
“…Despite the efforts of the in silico methods in trying to find the correct protein configurations, an appropriate algorithm that can work properly in a pure ab initio way is still missing, which is especially relevant when one wants to predict a protein that has low similarity with the known structures. There are some Evolutionary Algorithms (EA) and other optimization approaches with useful results for PSP [6,7,8,9]. The better the optimization technique, the better will be its chances of finding proper solutions.…”
Section: Introductionmentioning
confidence: 99%
“…The proposed approach uses ProtPred, an ab initio and full-atom model using a GA for PSP [17,[34][35][36][37][38][39]. It applies the force field potentials from the Tinker package [40] to compute the energy of a protein configuration.…”
Section: Introductionmentioning
confidence: 99%
“…Os trabalhos de LIMA (2006);LIMA et al (2007) desencadearam o desenvolvimento do software chamado ProtPred, recentemente publicado em BRASIL; DELBEM; BONETTI (2011),é aplicado no PSP modelando-o como um problema de otimização mono e multiobjetivo. Para a computação das propriedades da proteínaé utilizado implementações baseadas no Tinker (PONDER, 2001).…”
Section: Objetivos E Contribuições Da Presente Pesquisaunclassified
“…O ProtPred (LIMA et al, 2007); (BRASIL; DELBEM; BONETTI, 2011)é um software para investigar o PSP no qual se permite modelá-lo como um problema de otimização. Inclusive, existe a versão do mesmo tratando o PSP em um modelo HP (GABRIEL; MELO; DELBEM, 2012).…”
Section: Apresentando O Protpredunclassified
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