Evolution of trapped ion cells in Fourier transform ion cyclotron resonance mass spectrometry

Anderson, Jacob S.; Vartanian, Victor; Laude, David A.

doi:10.1016/0165-9936(94)87048-9

Cited by 15 publications

(10 citation statements)

References 16 publications

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“…However, we do not present the basic operating principles of these methods. Several reviews of instrumentation are especially relevant to this work, including several papers on quadrupole mass filters, [3][4][5] ion traps, [6][7][8][9] Fourier transform ion cyclotron resonance (FTICR), [10][11][12][13] ion mobility spectrometry, [14][15][16] dissociation methods, 17 and microscopies. 18,19 The gas-phase structural work also benefits from sophisticated molecular modeling software used for generating trial conformations.…”

Section: A Scope and Organization Of This Reviewmentioning

confidence: 99%

“…However, we do not present the basic operating principles of these methods. Several reviews of instrumentation are especially relevant to this work, including several papers on quadrupole mass filters, − ion traps, − Fourier transform ion cyclotron resonance (FTICR), − ion mobility spectrometry, − dissociation methods, and microscopies. , …”

Section: A Scope and Organization Of This Reviewmentioning

confidence: 99%

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Anhydrous Protein Ions

1999

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Section: A Scope and Organization Of This Reviewmentioning

confidence: 99%

“…However, we do not present the basic operating principles of these methods. Several reviews of instrumentation are especially relevant to this work, including several papers on quadrupole mass filters, − ion traps, − Fourier transform ion cyclotron resonance (FTICR), − ion mobility spectrometry, − dissociation methods, and microscopies. , …”

Section: A Scope and Organization Of This Reviewmentioning

confidence: 99%

Anhydrous Protein Ions

1999

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“…Typically the attained field quality is a compromise among the desired field parameters [22]. A large number of ICR cell designs have been developed to target one or more of these electric field features [23, 24] and the most common ICR cell geometries in use today are designed to emulate infinitely long excitation electrodes [25, 26]. …”

Section: Introductionmentioning

confidence: 99%

A novel fourier transform ion cyclotron resonance mass spectrometer with improved ion trapping and detection capabilities

Kaiser

Skulason

Weisbrod

et al. 2009

J. Am. Soc. Mass Spectrom.

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A novel Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer has been developed for improved biomolecule analysis. A flared metal capillary and an electrodynamic ion funnel were installed in the source region of the instrument for improved ion transmission. The transfer quadrupole is divided into 19 segments, with the capacity for independent control of DC voltage biases for each segment. Restrained ion population transfer (RIPT) is used to transfer ions from the ion accumulation region to the ICR cell. The RIPT ion guide reduces mass discrimination that occurs as a result of time-of-flight effects associated with gated trapping. Increasing the number of applied DC bias voltages from 8 to 18 increases the number of ions that are effectively trapped in the ICR cell. The RIPT ion guide with a novel voltage profile applied during ion transfer provides a 3-to 4-fold increase in the number of ions that are trapped in the ICR cell compared with gated trapping for the same ion accumulation time period. A novel ICR cell was incorporated in the instrument to reduce radial electric field variation for ions with different z-axis oscillation amplitudes. With the ICR cell, called trapping ring electrode cell (TREC), we can tailor the shape of the trapping electric fields to reduce dephasing of coherent cyclotron motion of an excited ion packet. With TREC, nearly an order of magnitude increase in sensitivity is observed. The performance of the instrument with the combination of RIPT, TREC, flared inlet, and ion funnel is presented. (J Am Soc Mass Spectrom 2009, 20, 755-762)

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“…In this paper, we describe a new FTICR cell design that is based on a multiple rod and ring electrode design that has the aim of providing improved performance for large molecule analyses. Many different ICR ion traps have been developed over the past few years 20–28. A recent paper by Jackson et al 28 highlights the culmination of development efforts aimed at achieving greater flexibility and trap performance carried out at the FTICR facility in the National High Magnetic Field Laboratory.…”

Section: Introductionmentioning

confidence: 99%