Evolution of the unfolded protein response in plants

Howell, Stephen H.

doi:10.1111/pce.14063

Cited by 33 publications

(41 citation statements)

References 53 publications

(91 reference statements)

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“…In plants, abiotic and biotic stress can result in misfolded proteins, which accumulate in the ER and cause ER stress, toxicity, and programmed cell death (see review [83]). In order to maintain ER homeostasis, cells activate the unfolded protein response, upregulating genes involved in preserving the protein quality and quantity [84]. While genes involved in the unfolded protein response were not statistically overrepresented in our study, they were significantly overrepresented in Clark roots at 30 min after iron stress [20].…”

Section: Identifying Targets For Future Analysesmentioning

confidence: 49%

Comparing Early Transcriptomic Responses of 18 Soybean (Glycine max) Genotypes to Iron Stress

Kohlhase

McCabe

Singh

et al. 2021

IJMS

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Iron deficiency chlorosis (IDC) is an abiotic stress that negatively affects soybean (Glycine max [L.] Merr.) production. Much of our knowledge of IDC stress responses is derived from model plant species. Gene expression, quantitative trait loci (QTL) mapping, and genome-wide association studies (GWAS) performed in soybean suggest that stress response differences exist between model and crop species. Our current understanding of the molecular response to IDC in soybeans is largely derived from gene expression studies using near-isogenic lines differing in iron efficiency. To improve iron efficiency in soybeans and other crops, we need to expand gene expression studies to include the diversity present in germplasm collections. Therefore, we collected 216 purified RNA samples (18 genotypes, two tissue types [leaves and roots], two iron treatments [sufficient and deficient], three replicates) and used RNA sequencing to examine the expression differences of 18 diverse soybean genotypes in response to iron deficiency. We found a rapid response to iron deficiency across genotypes, most responding within 60 min of stress. There was little evidence of an overlap of specific differentially expressed genes, and comparisons of gene ontology terms and transcription factor families suggest the utilization of different pathways in the stress response. These initial findings suggest an untapped genetic potential within the soybean germplasm collection that could be used for the continued improvement of iron efficiency in soybean.

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Section: Identifying Targets For Future Analysesmentioning

confidence: 49%

Comparing Early Transcriptomic Responses of 18 Soybean (Glycine max) Genotypes to Iron Stress

Kohlhase

McCabe

Singh

et al. 2021

IJMS

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“…Moreover, bZIP60u protein has been shown to undergo constant action by the proteasome system, and its function remains elusive. Among plant species, IRE1 may be represented by one or more isoforms depending on the species; for example, the rice genome encodes a single IRE1 isoform, while Arabidopsis and soybean genomes encode two and four isoforms, respectively (Nagashima et al, 2011;Wakasa et al, 2012;Silva et al, 2015;Howell, 2021). Besides the two full-length isoforms, the Arabidopsis genome also has a third IRE1 gene (IRE1c), which generates a truncated protein lacking the sensor domain and might play a role beyond the ER stress responses.…”

Section: Plant Er Stress Elicitation and Conserved Features Of Plant Uprmentioning

confidence: 99%

Cell Death Signaling From Endoplasmic Reticulum Stress: Plant-Specific and Conserved Features

et al. 2022

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The endoplasmic reticulum (ER) stress response is triggered by any condition that disrupts protein folding and promotes the accumulation of unfolded proteins in the lumen of the organelle. In eukaryotic cells, the evolutionarily conserved unfolded protein response is activated to clear unfolded proteins and restore ER homeostasis. The recovery from ER stress is accomplished by decreasing protein translation and loading into the organelle, increasing the ER protein processing capacity and ER-associated protein degradation activity. However, if the ER stress persists and cannot be reversed, the chronically prolonged stress leads to cellular dysfunction that activates cell death signaling as an ultimate attempt to survive. Accumulating evidence implicates ER stress-induced cell death signaling pathways as significant contributors for stress adaptation in plants, making modulators of ER stress pathways potentially attractive targets for stress tolerance engineering. Here, we summarize recent advances in understanding plant-specific molecular mechanisms that elicit cell death signaling from ER stress. We also highlight the conserved features of ER stress-induced cell death signaling in plants shared by eukaryotic cells.

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“…Monocot plants such as rice have a single IRE1 gene. Dicots usually have two homologs, IRE1a and IRE1b , and Brassicas additionally have IRE1c [ 25 , 33 ]. Under ER stress, luminal domains of AtIRE1s sense this change, and then cytoplasmic domains of AtIRE1s splice AtbZIP60 mRNA [ 33 ].…”

Section: Perceptions and Responses Under Plant Er Stressmentioning

confidence: 99%

Endoplasmic Reticulum Stress and Reactive Oxygen Species in Plants

et al. 2022

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The endoplasmic reticulum (ER) is a key compartment responsible for protein processing and folding, and it also participates in many signal transduction and metabolic processes. Reactive oxygen species (ROS) are important signaling messengers involved in the redox equilibrium and stress response. A number of abiotic and biotic stresses can trigger the accumulation of unfolded or misfolded proteins and lead to ER stress. In recent years, a number of studies have reported that redox metabolism and ROS are closely related to ER stress. ER stress can benefit ROS generation and even cause oxidative burden in plants, finally leading to oxidative stress depending on the degree of ER stress. Moreover, ER stress activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-mediated ROS signaling, increases antioxidant defense mechanisms, and alters the glutathione (GSH) redox state. Meanwhile, the accumulation of ROS plays a special role in inducing the ER stress response. Given these factors, plants have evolved a series of complex regulatory mechanisms to interact with ROS in response to ER stress. In this review, we summarize the perceptions and responses of plant ER stress and oxidative protein folding in the ER. In addition, we analyze the production and signaling of ROS under ER stress in detail in order to provide a theoretical basis for reducing ER stress to improve the crop survival rate in agricultural applications.

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Evolution of the unfolded protein response in plants

Cited by 33 publications

References 53 publications

Comparing Early Transcriptomic Responses of 18 Soybean (Glycine max) Genotypes to Iron Stress

Comparing Early Transcriptomic Responses of 18 Soybean (Glycine max) Genotypes to Iron Stress

Cell Death Signaling From Endoplasmic Reticulum Stress: Plant-Specific and Conserved Features

Endoplasmic Reticulum Stress and Reactive Oxygen Species in Plants

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