Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A

Biancotto, Angélique; Grivel, Jean‐Charles; Lisco, Andrea; Vanpouille, Christophe; Markham, Phillip D.; Gallo, Robert C.; Margolis, Leonid; Lusso, Paolo

doi:10.1186/1742-4690-6-61

Cited by 17 publications

(12 citation statements)

References 33 publications

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“…This phenotypic switch is typically accompanied by an accelerated loss of CD4+ T cells and suppression of Th1 polarized responses that play an essential role in the clearance of viral infections. These results are conclusive in vivo evidence that HHV-6A accelerates the progression of SIV toward full-blown AIDS (Biancotto et al, 2009), and excellently support human clinical and experimental data on the interaction of HHV-6A and HIV-1.…”

Section: Human Herpesvirus 7 As a Negative Competitor Of Hiv Infectionsupporting

confidence: 68%

In Vitro and In Vivo Transactivation of HIV-1 by Human Herpesvirus 6

Ongradi¹,

Kövesdi²,

Nagy³

et al. 2011

HIV-Host Interactions

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Section: Human Herpesvirus 7 As a Negative Competitor Of Hiv Infectionsupporting

confidence: 68%

In Vitro and In Vivo Transactivation of HIV-1 by Human Herpesvirus 6

Ongradi¹,

Kövesdi²,

Nagy³

et al. 2011

HIV-Host Interactions

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“…In two separate studies, HHV-6A was detected in blood DNA from hospitalized febrile HIV+ children from this geographic population [18, 72]. Although this specific correlation awaits further confirmation from other tissue sites and from populations in other regions of Africa, this finding is potentially significant because HHV-6A has been proposed as a potential accelerating factor in HIV infection, as corroborated by the results of in vivo studies in macaques [19, 87]. …”

Section: Distinct Epidemiology and Disease Associationsmentioning

confidence: 62%

Classification of HHV-6A and HHV-6B as distinct viruses

et al. 2013

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Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

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“…Once diluted, the medium may be delicately pipeted ontop the block and gelfoam to ensure a faster diffusion. (28) In each drug-untreated control condition, add 10 μL of the drug specific buffer used to dilute the drug in step 5.…”

Section: Methodsmentioning

confidence: 99%

Histocultures (Tissue Explants) in Human Retrovirology

Arakelyan

Fitzgerald

Grivel

et al. 2014

Methods in Molecular Biology

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Summary Viral pathogenesis is studied predominantly in cultures of primary isolated cells or cell lines. Many retroviruses efficiently replicate only in activated cells. Therefore, in order to become efficient viral producers cells should be artificially activated, a procedure which significantly changes cell physiology. However, for many viral diseases, like HIV-1 and other retroviruses’ diseases, critical pathogenic events occur in tissues and cell isolation from their native microenvironment prevents single cell cultures from faithfully reflecting important aspects of cell-cell and cell-pathogen interactions that occur in the context of complex tissue cytoarchitecture. Tissue explants (histocultures) that retain tissue cytoarchitecture and many aspects of cell-cell interactions more faithfully represent in vivo tissue features. Human histocultures constitute an adequate model for studying viral pathogenesis under controlled laboratory conditions. Protocols for various human histocultures as applied to study retroviral pathogenesis, in particular of HIV-1, have been refined by our laboratory and are described in the present publication. Human histocultures of human tonsils and lymph nodes, as well as of recto-sigmoid and cervico-vaginal tissues can be used to study viral transmission, pathogenesis and as a pre-clinical platform for antivirals evaluation.

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Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A

Cited by 17 publications

References 33 publications

In Vitro and In Vivo Transactivation of HIV-1 by Human Herpesvirus 6

In Vitro and In Vivo Transactivation of HIV-1 by Human Herpesvirus 6

Classification of HHV-6A and HHV-6B as distinct viruses

Histocultures (Tissue Explants) in Human Retrovirology

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